Protein Alignment AdamTS-B and adamts16

DIOPT Version :10

• Sequence 1: NP_572247.2
• Gene: AdamTS-B / 31490
• FlyBaseID: FBgn0029791
• Length: 1023
• Species: Drosophila melanogaster
• Sequence 2: XP_001922446.4
• Gene: adamts16 / 568792
• ZFINID: ZDB-GENE-130530-760
• Length: 1224
• Species: Danio rerio
• Alignment Length: 1065
• Identity: 343/1065 - (32%)
• Similarity: 500/1065 - (46%)
• Gaps: 169/1065 - (15%)

  Fly    45 EGQLVVPRRVHPDGAFMTHQLEYAHELDHRRHRQRRSLNSEHDTQAADLHLLLPLANETLHLELM 109
            |.:||.|..|.|:|.:::|.:.:       :||.:||      |.|:.:|..|........|:|.
Zfish    60 EYELVSPYEVDPEGQYISHAVSH-------QHRSKRS------TDASTVHFRLQGLGREFQLDLR 111

  Fly   110 AHSYFLAPNLVVERHRRDLRTRSPLT-TRHLNCHFHGKVRGQPATNVAISTCAGLVGHIRTAGNE 173
            .....:|....|:...|. .|||..| ...:.|.:.|::|.|..::||:|||||:.|.|||...:
Zfish   112 PSRGLIAAEFTVQTLGRS-GTRSLQTLDGEMMCFYQGELRMQEHSSVALSTCAGMSGLIRTRDAD 175

  Fly   174 YFIEPSKEHE--------PHPVNGHPHVVFQRSSVKPKHSLRKRNKRKRGGKSGSGAEVSNCGTR 230
            ||::|...|:        |.| :..||::::|    |..:..:|.:|....:.|..|
Zfish   176 YFLKPLHPHQALLENFSAPSP-DHQPHILYKR----PAPTNTRRTRRSSEPRPGDSA-------- 227

  Fly   231 EPRRRMETRLEWQARGKVKVQGGRQIRRHHH------HHHHHHHKHKYRHHQQKISRVPHTKFKY 289
            .|.|       |:.        .||..::.|      ......||:..|..|....|    :.||
Zfish   228 IPNR-------WRT--------SRQAEKNTHTLINPEEMQKTTHKNSTRRRQHYCGR----RKKY 273

  Fly   290 -----ETQFQTEPDHAEI-PRRRRSI------SSPRHVETLIVADATM--SAFHRDLNGYLLTIM 340
                 |......||..:: ||.:|.:      ....:||||:|.|..|  :..|.::..|:||::
Zfish   274 MPKPPEEDIYIFPDEYKLMPRGKRDVVFKPETQQSLNVETLVVVDRKMMDNHGHENITTYVLTVL 338

  Fly   341 NMVSALYKDPSIGNSIEIVVVRIIQLDEEESQLQLNLTQNAQKNLDRFCSWQHKLNKGSEKDPHH 405
            ||||.|:||.:||.:|.:|:|.:|.|||::..|.:|  .:|...|:.||.||..|   |.::...
Zfish   339 NMVSTLFKDGTIGGNINVVIVGLILLDEDQDGLVIN--HHADHTLNSFCQWQSGL---SGREGRR 398

  Fly   406 HDVAILITRKNICA---NNCMTLGLANVGGMCKPKQSCSVNEDNGIMLSHTITHELGHNFGMFHD 467
            ||.|||:|..:||:   ..|.|||.|.:.|||...:||::|||.|:.|:.||.||.||||||.||
Zfish   399 HDHAILLTGLDICSWKNEPCDTLGFAPISGMCSKYRSCTINEDTGLGLAFTIAHESGHNFGMVHD 463

  Fly   468 TAKIGCHPRVGPIVHIMTPTFGADTLQVCWSNCSRKYITHFLDQGLGECLDDPPTPLDEYNYTGE 532
            .....|...||   :||:||.........||:|||:|:..||......||.|.|:.:.||.|..:
Zfish   464 GEGNVCKKSVG---NIMSPTLAGHNGLFSWSSCSRQYLNRFLSSAQATCLSDEPSAIQEYKYPEK 525

  Fly   533 LPGMRYNARGQCRLQFNLTTDSEVGACSA--PHEFCSTLWC-KVNGECVTHMRPTAPGTLCGRNK 594
            |||..|:|..||:.||.    .:...|:.  ..:.|..||| :...:|.|...|.|.|:.||...
Zfish   526 LPGELYDADTQCKWQFG----EKAKLCTLDFKKDICKALWCHRFGRKCETKFMPAAEGSACGPEM 586

  Fly   595 WCQNGKCVRREELA--AVNGGWGDWSEWSECSRSCGGGVSTQQRECDNPVPANGGVFCIGERKRY 657
            ||:.|:||::.:..  ||:|.|..||.||.|||||..||:.:.|.|.:|.||:||.||.|..:.|
Zfish   587 WCRGGQCVKQADAGPKAVDGQWSTWSGWSSCSRSCESGVTHRDRVCSSPRPAHGGRFCEGSSRSY 651

  Fly   658 KICRKRPCPAEEPSFRAQQCARFDNVSYQGATYKWLPF--FDKNNPCKLFCSDVDDTIIANWGAT 720
            |:|....|||....|||.|||.|::..::|..|||.|:  .|..:.|||:|............:.
Zfish   652 KLCNTDDCPANAVDFRAAQCAEFNSKPFRGWYYKWRPYTRVDDQDVCKLYCLAEGYDFFFALSSK 716

  Fly   721 VLDGTPCTLGTNNMCIDGICKKVGCDWIVDSEVQDDRCGVCGGSGDQCQPVRETYTDPFAAKDGA 785
            |.|||.|...:.::||||||:|||||.::.|....|.||||.|....|:..:..|:.......
Zfish   717 VRDGTLCAQDSTDVCIDGICEKVGCDRVLGSNAVPDMCGVCKGDNSTCKIYKGQYSKQHHLSQ-- 779

  Fly   786 YVEIVTIPARARHILIRELANSPHFLAIATGDGGDRFYLNGDSLISMPGEFEIAGAESLYDR-VD 849
            |..:|||||.||.|.:.||.:|..:||:....  .::||||...:..||...||||...|.| .:
Zfish   780 YYRVVTIPAGARSIRVSELNSSSSYLALRNLQ--RKYYLNGAWTVDWPGRHSIAGAIFDYKRPYN 842

  Fly   850 EQETITIPQPIQHSISLYAIVRGNESNAGIFYEFTL---------------PALNVTAGRQ---- 895
            ..|:::...|...::.:..:::|  .|.|:.:|:||               ...:..||.|
Zfish   843 RPESLSSSGPTNQTLVIEVLLQG--WNPGVQWEYTLNREQKHNYSWAVVRSQCSSSCAGGQMVSK 905

  Fly   896 --------FQ---------------------------WRLSNWTACSASCGGGVQHREPIC-QEN 924
                    ||                           |.:.:|::||.|||.|.|.|..:| |:.
Zfish   906 SICYRDLRFQVNSSYCSARSRPSSGVMSCNTQPCPASWSVQDWSSCSRSCGSGQQVRRVVCVQKT 970

  Fly   925 GKALGDTLPCWTHAKNKRPA-RQSRGCGDQPCPAHWWPGPWQFCPVTCRPVGFVAPPQRRRSVVC 988
            |.   |.|.....|:..:|| ..:..|....||..|..|.|..|...|      .....:|.|:|
Zfish   971 GP---DQLETVADAQCPQPAPAHTHSCNTHSCPPAWSAGAWTQCSRKC------GKGVMKRPVLC 1026

  Fly   989 LDEHDVVVADAECGHLQKPAEMEPC 1013
            :..:.||:.|:.|..|.||:..|.|
Zfish  1027 VLSNGVVLPDSSCADLLKPSVQEIC 1051

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
AdamTS-B	NP_572247.2	Pep_M12B_propep	47..195	CDD:460254	47/156 (30%)
		ZnMc_ADAMTS_like	314..518	CDD:239801	88/208 (42%)
		ADAMTS_CR_2	534..602	CDD:465496	23/70 (33%)
		TSP1	614..666	CDD:214559	25/51 (49%)
		ADAMTS_CR_3	672..768	CDD:437068	40/97 (41%)
		ADAMTS_spacer1	770..886	CDD:461796	35/131 (27%)
		TSP1	901..956	CDD:214559	18/56 (32%)
		TSP1_ADAMTS	959..1020	CDD:465950	17/55 (31%)
adamts16	XP_001922446.4	None