DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment AdamTS-B and si:ch211-267e7.3

DIOPT Version :9

Sequence 1:	NP_572247.2	Gene:	AdamTS-B / 31490	FlyBaseID:	FBgn0029791	Length:	1023	Species:	Drosophila melanogaster
Sequence 2:	XP_696251.5	Gene:	si:ch211-267e7.3 / 567853	ZFINID:	ZDB-GENE-070912-265	Length:	963	Species:	Danio rerio

Alignment Length:	363	Identity:	115/363 - (31%)
Similarity:	169/363 - (46%)	Gaps:	65/363 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   554 SEVGACSAPHEFCSTLWCKVNGECVTHMRPTAPGTLCGRNKWCQNGKCVRREELA----AVNGGW 614
            :.||....|: |...:|. :|.....:::.::.|                ||:|.    .|...|
Zfish     7 ARVGHTLLPY-FLIHVWI-INTAAGVNVKDSSEG----------------REDLQRHPDEVAQWW 53

  Fly   615 GDWSEWSECSRSCGGGVSTQQREC-DNPVPANGGV---FCIGERKRYKICRKRPCPAEEPSFRAQ 675
            |:||.||.|||:|||||.:|:|.| ...:.:...:   ||||..|:|::|..:|||....||:..
Zfish    54 GEWSSWSTCSRTCGGGVRSQERHCLQQRLTSTQNINSSFCIGPSKQYQLCTNQPCPNSRISFKQH 118

  Fly   676 QCARFDNVSYQGATYKWLPFFD------KNNPCKLFCSDVDDTIIANWGATVL-----DGTPCTL 729
            ||::|:..::....|:|:|.:.      .|.||.|.|:       ...|...|     |||.|..
Zfish   119 QCSQFNAKAFSRKHYEWVPLYPDDYINISNKPCDLQCT-------TTTGERQLLVPAHDGTFCRD 176

  Fly   730 GT-NNMCIDGICKKVGCDWIVDSEVQDDRCGVCGGSGDQCQPVRETYTDPFAAKDG----AYVEI 789
            |. ..:||:|.|:.||||..:.|....|:||||||:|..|..|..||      :.|    .||.|
Zfish   177 GIYQGVCIEGQCQVVGCDGKLYSSKTIDKCGVCGGNGASCYRVSGTY------RKGITQLGYVFI 235

  Fly   790 VTIPARARHILIRELANSPHFLAIATGDGGDRFYLNGDSLISMPGEFEIAGAESLYDR-----VD 849
            ..||..|..|.|.|...:.:.||::  |....|:.||:|:|..|..|.:||....|.|     .|
Zfish   236 TNIPVGATDIQIIERRKTENILALS--DEAGHFFFNGNSVIDNPQNFHVAGTVFKYRRPANLFSD 298

  Fly   850 EQETITIPQPIQHSIS-LYAIVRGNESNAGIFYEFTLP 886
            ..|.|....|.|.::: :|..:.|...:  |.||:|:|
Zfish   299 GFEYIMAQGPTQQALNVMYYNLNGKMPH--ITYEYTVP 334

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AdamTS-B	NP_572247.2	Pep_M12B_propep	78..194	CDD:279848
		ZnMc_ADAMTS_like	314..518	CDD:239801
		Reprolysin	315..521	CDD:279729
		ADAM_CR	<558..602	CDD:301627	5/43 (12%)
		TSP1	614..666	CDD:214559	25/55 (45%)
		ADAM_spacer1	773..886	CDD:283607	37/122 (30%)
		TSP1	901..956	CDD:214559
si:ch211-267e7.3	XP_696251.5	TSP1	53..109	CDD:214559	25/55 (45%)
		ADAM_spacer1	217..334	CDD:283607	38/126 (30%)
		TSP1	637..>660	CDD:214559
		TSP1	700..749	CDD:214559
		TSP1	752..806	CDD:214559
		TSP1	865..918	CDD:214559
		PLAC	928..959	CDD:285849
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3538
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.810