Protein Alignment AdamTS-B and adamts5

DIOPT Version :10

• Sequence 1: NP_572247.2
• Gene: AdamTS-B / 31490
• FlyBaseID: FBgn0029791
• Length: 1023
• Species: Drosophila melanogaster
• Sequence 2: NP_001289160.1
• Gene: adamts5 / 565053
• ZFINID: ZDB-GENE-070814-2
• Length: 937
• Species: Danio rerio
• Alignment Length: 1088
• Identity: 307/1088 - (28%)
• Similarity: 445/1088 - (40%)
• Gaps: 291/1088 - (26%)

  Fly    20 WLVV----VTQGGGVRPLYGLHSDELVAGEGQLVVPRRVHPDGAFMTHQLEYAHELDHRRHRQRR 80
            ||||    |......||   ..:..|:|.:|.:....|::..|.    :..|...||    .||.
Zfish     2 WLVVLLCCVLDASVARP---PANASLLAPDGTVRAVDRIYHGGG----KAGYLLYLD----EQRF 55

  Fly    81 SLNSEHDTQAADLHLLLPLANETLHLELMAHSYFL-APNLVVERHRRDLRTRSPLTTRHLNCHFH 144
            .|:.|.|....|                  |.:.. ||      .||:             |.:.
Zfish    56 QLDMERDETIPD------------------HQFSADAP------PRRE-------------CVYR 83

  Fly   145 GKVRGQPATNVAISTC-AGLVGHIRTAGNEYFIEP---SKEHEPHPVNGHPHVVFQRSSVKPKH- 204
            |.|.....:....:.| .||.|......:.|.|.|   :|.||     ...|:|....:.:..|
Zfish    84 GTVNSNAQSLAVFNLCGGGLEGFFALDHSRYTITPVIRAKGHE-----NDVHIVEDADATRALHL 143

  Fly   205 SLRKRNKRKRGGKSGSGAEVSNCGTREPRRRMETRLEWQARGKVKVQGGRQIRRHHHHHHHHHHK 269
            ..|:|...:      :..|..:||||:.:.|                                 |
Zfish   144 YTRERFSFE------AMPERHSCGTRDRKTR---------------------------------K 169

  Fly   270 HKYRHHQQKISRVPHTKFKYETQFQTEPDHAEIPRRRRSISSPRHVETLIVADATMS-AFHRDLN 333
            ||...|.:          ::.|:| ..|| |...||:||:|..||||.|:||||:|: .:.:||.
Zfish   170 HKKEMHGR----------RWWTKF-IRPD-ASPTRRKRSVSRARHVELLLVADASMTKKYGKDLQ 222

  Fly   334 GYLLTIMNMVSALYKDPSIGNSIEIVVVRIIQLDEEESQLQLNLTQNAQKNLDRFCSWQHKLNKG 398
            .||||:.::.|.||...||.|.|.:.||::..|.|.|..::  :::||...|..||.||::.|..
Zfish   223 HYLLTLASIASKLYGHASIENPIRLSVVKVALLSEHEKGIE--ISKNAAATLKSFCKWQNQQNPL 285

  Fly   399 SEKDPHHHDVAILITRKNICA-NNCMTLGLANVGGMCKPKQSCSVNEDNGIMLSHTITHELGHNF 462
            .:...||||.|||.||:::|. ::|.|||:|:||.:|.|::||::.||:|:..:.|:.||:||..
Zfish   286 DDDHQHHHDAAILFTRQDLCGHHSCDTLGMADVGTVCSPERSCAIIEDDGLHAAFTVAHEIGHLL 350

  Fly   463 GMFHDTAKIGCHPRVGPI--VHIMTPTFGADTLQVCWSNCSRKYITHFLDQGLGEC-LDDPPTPL 524
            |:.||.:|. |..|.|..  ..:|:....:......||.|:...||.|.|.|..|| ||.|..||
Zfish   351 GLSHDDSKF-CEERFGSSEDKRLMSSILTSIDASKPWSRCTSNTITDFFDDGNAECLLDAPRVPL 414

  Fly   525 DEYNYTG--ELPGMRYNARGQCRLQFNLTTDSEVGACSAPHEFCSTLWCKV--NGE--CVTHMRP 583
                 .|  ||||..|:|..||||.|.    ||...|.. .:.|:.|||.|  .|:  |:|...|
Zfish   415 -----LGPEELPGQSYDAVQQCRLAFG----SEYSVCPG-MDICARLWCSVIRKGQMVCLTKKLP 469

  Fly   584 TAPGTLCGRNKWCQNGKCV----RREELAAVNGGWGDWSEWSECSRSCGGGVSTQQRECDNPVPA 644
            ...||.||:.:.|..||||    :|....:.:|.|..|..|..|||||||||...||.|:||.|.
Zfish   470 AVEGTPCGKGRICLQGKCVDKTKKRHYSTSKDGSWSSWGAWGSCSRSCGGGVQFAQRLCNNPAPR 534

  Fly   645 NGGVFCIGERKRYKICRKRPCPAEEPSFRAQQCARFDNVSYQGATYK----WLPFFDKNNP---C 702
            |.|.:|.|:|..|:.|...|||....|||.:||...:.........|    |:|.|....|   |
Zfish   535 NNGRYCTGKRAVYRSCSVTPCPTTGKSFRQEQCEVRNGPQTDPKGVKTLVEWVPKFAGVLPKDVC 599

  Fly   703 KLFCSDVDDTIIANWGATVLDGTPCTLGTNNMCIDGICKKVGCDWIVDSEVQDDRCGVCGGSGDQ 767
            ||.|..........:...|:|||.|...::::|:.|.|.:.|||.|:.|::|.|:||:|||.|:.
Zfish   600 KLTCRAKGTGYYVVFSQRVVDGTECRPYSSSVCVKGKCVRTGCDGIIGSKLQYDKCGICGGDGNS 664

  Fly   768 CQPVRETYTDPFAAKDGAYVEIVTIPARARHILIREL-----ANSPHFLAIATGDGGDRFYLNG- 826
            |..|...:|    .|...|.::|.||..:.|:.:|:.     :....:||:.. .||| :.|||
Zfish   665 CIKVAGNFT----KKSKGYTDVVKIPEGSTHLKVRQYKAKGQSRYTAYLALRR-PGGD-YLLNGK 723

  Fly   827 ------DSLISMPGE-------------FEIAGAESLYDRV-------DEQETITI--------- 856
                  :::|.:.|.             |...|..:|.:.:       |.::.:.|
Zfish   724 LMISTSETIIPLNGSVLNYTGWSQRDEAFHSMGPAALQESLLVQILSTDAKKPLDIRYSFFMPRK 788

  Fly   857 -PQPIQHS----------------------ISLYAIVR--------------------------- 871
             |.|.:.|                      :||.|..|
Zfish   789 TPLPARTSPEAPPRMSLEAPPRMSLEAPPRMSLEAPPRMAPEALPRTSPEAPPRIPPEAPPRTPP 853

  Fly   872 ------GNESNAGIFYEFTLPALNVTAGRQF-QWRLSNWTACSASCGGGVQHREPICQE-NGKAL 928
                  .:.|:|.: ..||......|...:| :|....|.:||.:|..|.|.|...|:: |||.
Zfish   854 EAPPTVASLSSAEL-VTFTSDVPPTTESPKFPRWLTGPWMSCSRTCDTGWQSRTVQCKDANGKL- 916

  Fly   929 GDTLPCWTHAKNKRPARQSRGCGDQPCPAHWWPGPWQFCPVTCRPVGF 976
                     :||                          ||::.||..|
Zfish   917 ---------SKN--------------------------CPLSARPSAF 929

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
AdamTS-B	NP_572247.2	Pep_M12B_propep	47..195	CDD:460254	30/152 (20%)
		ZnMc_ADAMTS_like	314..518	CDD:239801	82/208 (39%)
		ADAMTS_CR_2	534..602	CDD:465496	28/71 (39%)
		TSP1	614..666	CDD:214559	26/51 (51%)
		ADAMTS_CR_3	672..768	CDD:437068	34/102 (33%)
		ADAMTS_spacer1	770..886	CDD:461796	35/212 (17%)
		TSP1	901..956	CDD:214559	13/55 (24%)
		TSP1_ADAMTS	959..1020	CDD:465950	5/18 (28%)
adamts5	NP_001289160.1	Pep_M12B_propep	<46..132	CDD:460254	28/131 (21%)
		ZnMc_ADAMTS_like	201..407	CDD:239801	83/208 (40%)
		ADAMTS_CR_2	421..488	CDD:465496	28/71 (39%)
		TSP1	504..556	CDD:214559	26/51 (51%)
		ADAMTS_CR_3	558..665	CDD:437068	35/106 (33%)
		ADAMTS_spacer1	667..786	CDD:461796	24/124 (19%)
		TSP1_ADAMTS	886..937	CDD:465950	19/80 (24%)