DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment AdamTS-B and adamts7

DIOPT Version :9

Sequence 1:	NP_572247.2	Gene:	AdamTS-B / 31490	FlyBaseID:	FBgn0029791	Length:	1023	Species:	Drosophila melanogaster
Sequence 2:	XP_021333676.1	Gene:	adamts7 / 560364	-ID:	-	Length:	1808	Species:	Danio rerio

Alignment Length:	1013	Identity:	359/1013 - (35%)
Similarity:	532/1013 - (52%)	Gaps:	124/1013 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 YGLHSDELVAG--EGQLVVPRRVHPDGAFMTHQLEYAHELDHRRHRQRRSLNSEHDTQAADLHLL 96
            |...:|..::|  ..::|.|.||...|.|:::.      :.||..|.:|....:...:...::..
Zfish    53 YNQDTDGSLSGVPSYEVVYPIRVDSSGHFLSNL------VSHRVSRIQRRETEKSKERLTQVYYY 111

  Fly    97 LPLANETLHLELMAHSYFLAPNLVVERHRRDLRTRSPLTTRHLNCHFHGKV------RGQPATNV 155
            |....:.||..|..:.:.|||..:.||....|:..:.....|..|.|.|.|      .||    .
Zfish   112 LQYGGQDLHFNLTLNPHLLAPGFLTERRYGGLQGSTLHGHGHSLCFFLGDVWSSMLKSGQ----A 172

  Fly   156 AISTCAGLVGHIRTAGNEYFIEPSKEHEPHPVNGHPHVVFQRSSVKPKHSLRKRNKRKRGGKSGS 220
            |:|||.||.|..:.:..|:||.| .|.|........|.:::|.:|:.:..|.:       ...|.
Zfish   173 AVSTCNGLTGLFKLSEEEFFISP-LEQEQEESTTQAHAIYKRHAVQSERQLVQ-------PLFGE 229

  Fly   221 GAEVSNCGTREPRRRMETRLE-WQARGKVKVQGGRQIRRHHHHHHHHHHKHKYRHHQQKISRVPH 284
            ....:.||.:....:.|.:.| |::|                               |:..|:
Zfish   230 HTANATCGVKGGAEQFERQRERWESR-------------------------------QQRKRI-- 261

  Fly   285 TKFKYETQFQTEPDHAEIPRRRRSISSPRHVETLIVADATMSAFH--RDLNGYLLTIMNMVSALY 347
                                |:||||:.:.||||:|||..|..:|  :.:..|:|::||:|:.|:
Zfish   262 --------------------RQRSISTEKWVETLVVADPKMVEYHGSKGVVSYVLSVMNIVAGLF 306

  Fly   348 KDPSIGNSIEIVVVRIIQLDEEESQLQLNLTQNAQKNLDRFCSWQHKLNKGSEKDPHHHDVAILI 412
            :|.||||:|.|.|||::.|:::|..|:  :|.:|..:|..||.||..:|...:..|.|||||:||
Zfish   307 RDASIGNAINIAVVRLVLLEKDEEDLK--ITHHADNSLHSFCKWQKNINMKDDDHPVHHDVAVLI 369

  Fly   413 TRKNICA---NNCMTLGLANVGGMCKPKQSCSVNEDNGIMLSHTITHELGHNFGMFHDTAKIGCH 474
            |||:|||   ..|.||||::|.|||:|.:|||:|||.|:.|:.||.||||||||:.||.....|.
Zfish   370 TRKDICAAINKPCETLGLSHVAGMCQPHRSCSINEDTGLPLAFTIAHELGHNFGIQHDGNGNDCE 434

  Fly   475 PRVGPIVHIMTPTFGADTLQVCWSNCSRKYITHFLDQGLGECLDDPPTPLDEYNYTGELPGMRYN 539
            | :|....:|:|.....|....||.|||:|||.|||:|.|.||||||. .:|.:.....||:.|:
Zfish   435 P-IGKRPFVMSPQLLYGTSPPNWSRCSREYITRFLDRGWGWCLDDPPV-RNELDLHPAPPGVLYS 497

  Fly   540 ARGQCRLQFNLTTDSEVGACSAPHEFCSTLWCKVNGECVTHMRPTAPGTLCGRNKWCQNGKCVRR 604
            |..||:||:.    |....|......||||||.|...|.:.:.....||.||.:|||.:|:||.:
Zfish   498 AAHQCKLQYG----SSSLLCDEVDNICSTLWCTVGSTCHSRLDGAVDGTKCGEDKWCFDGECVTK 558

  Fly   605 -EELAAVNGGWGDWSEWSECSRSCGGGVSTQQRECDNPVPANGGVFCIGERKRYKICRKRPCPAE 668
             .:..:|:|||..||:||:|||:||.||...||:|.||||..||.:|:|||:||:.|....||.:
Zfish   559 GTQPESVHGGWASWSDWSDCSRTCGTGVQNAQRDCINPVPKYGGRYCLGERQRYRTCNHESCPVD 623

  Fly   669 EPSFRAQQCARFDNVSYQGATYKWLPFFDKNNPCKLFCSDVDDTIIANWGATVLDGTPCTLG--T 731
            :||||..||:||:.|.|:|..|||:...::.|||:|.|..:::........||:|||.|..|  :
Zfish   624 QPSFRHMQCSRFNTVPYKGKFYKWIHVNNRVNPCELHCRPMNEHFSERMLDTVIDGTQCYEGSQS 688

  Fly   732 NNMCIDGICKKVGCDWIVDSEVQDDRCGVCGGSGDQCQPVRETYTDPFAAKDG-AYVEIVTIPAR 795
            .::|::||||.:|||:.:||:..:|:||||.|:|..|:.||:|:.|    .:| .||:|..||..
Zfish   689 RDICVNGICKYLGCDFEIDSDAVEDQCGVCLGNGSTCETVRKTFED----SEGLGYVDIGLIPEG 749

  Fly   796 ARHILIRELANSPHFLAIATGDGGDRFYLNGDSLISMPGEFEIAGAESLYDRVDEQETITIPQPI 860
            ||.|.|.|:|.:.::||:.:.| .::::|||...|...||::.||....|:|..:.|.::.|.|.
Zfish   750 ARDIRIEEVAEAGNYLALRSND-PEKYFLNGGWTIQWNGEYKAAGTIFTYERTGQLENLSSPGPT 813

  Fly   861 QHSISLYAIVRGNESNAGIFYEFT------LPALNVTAGRQFQWRLSNWTACSASCGGGVQHREP 919
            ...:.:..:.:  |:|.|:.||:|      |.:.|.||...|||....||.|||:||.|:|.:..
Zfish   814 MEPVWIQLLFQ--ETNPGVRYEYTISRDTLLDSSNGTAVSYFQWIYGAWTECSATCGTGMQRQIV 876

  Fly   920 ICQENGKALGDTLPCWTHAKNKRPARQSRGCGDQPCPAHWWPGPWQFCPVTCRPVGFVAPPQRRR 984
            .|.|....:.:...|   ..:.||..:...|....|||.||.|.||.|..:|..:|.     |:|
Zfish   877 HCVEKTSGIVEEHYC---DASMRPDDKQTSCNKGLCPAIWWAGDWQKCSSSCGEMGL-----RKR 933

  Fly   985 SVVC-----LDEHDVVVADAECGHLQKPAEMEPCESSL 1017
            :|:|     |||.. .:..|||.||.||..:.||.:.:
Zfish   934 TVLCIRSLGLDEQR-ALQPAECQHLPKPESIIPCNTQV 970

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AdamTS-B	NP_572247.2	Pep_M12B_propep	78..194	CDD:279848	32/121 (26%)
		ZnMc_ADAMTS_like	314..518	CDD:239801	100/208 (48%)
		Reprolysin	315..521	CDD:279729	103/210 (49%)
		ADAM_CR	<558..602	CDD:301627	17/43 (40%)
		TSP1	614..666	CDD:214559	28/51 (55%)
		ADAM_spacer1	773..886	CDD:283607	36/119 (30%)
		TSP1	901..956	CDD:214559	15/54 (28%)
adamts7	XP_021333676.1	Pep_M12B_propep	68..211	CDD:307618	41/153 (27%)
		ZnMc_ADAMTS_like	270..477	CDD:239801	100/209 (48%)
		ADAM_CR	<513..556	CDD:326582	17/42 (40%)
		ADAM_CR	540..697	CDD:326582	71/156 (46%)
		TSP1	569..621	CDD:214559	28/51 (55%)
		ADAM_spacer1	726..836	CDD:310520	37/116 (32%)
		TSP1	855..910	CDD:214559	16/57 (28%)
		TSP1	976..1025	CDD:214559
		Herpes_U47	<1363..>1441	CDD:283192
		TSP1	1588..1646	CDD:214559
		TSP_1	1651..1695	CDD:326556
		TSP1	1698..1755	CDD:214559
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	210	1.000	Domainoid score	I2752
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H22803
Inparanoid	1	1.050	612	1.000	Inparanoid score	I879
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D125522at2759
OrthoFinder	1	1.000	-	-		FOG0001196
OrthoInspector	1	1.000	-	-		otm25151
orthoMCL	1	0.900	-	-		OOG6_100241
Panther	1	1.100	-	-	LDO	PTHR13723
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2816
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	11	10.970