DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment AdamTS-B and adamtsl7

DIOPT Version :9

Sequence 1:	NP_572247.2	Gene:	AdamTS-B / 31490	FlyBaseID:	FBgn0029791	Length:	1023	Species:	Drosophila melanogaster
Sequence 2:	XP_017211532.2	Gene:	adamtsl7 / 556634	ZFINID:	ZDB-GENE-070816-2	Length:	643	Species:	Danio rerio

Alignment Length:	396	Identity:	97/396 - (24%)
Similarity:	141/396 - (35%)	Gaps:	143/396 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly   744 GCDWIVDSEVQDDRCGVCGGSGDQCQPVRET-YTDPFAAKDGAYVEIVTIPARARHILIRELANS 807
            ||:..     |.|.||||.|.|..|:....| :....:.:   |.:|:.||:.|..|.|:|...:
Zfish    47 GCEGF-----QVDVCGVCAGDGSSCELFNGTIFLSVLSVR---YHKILNIPSGALRIKIQETHKT 103

  Fly   808 PHFLAI--ATGDGGDRFYLNGDSLISMPGEFEIAGAESLYDRVDE-----QETITIPQPIQHSIS 865
            .::||:  |||:.    .:|||.:|..||:|..||.:..|.|.:|     .|:||.|.|....::
Zfish   104 RNYLALSMATGES----VINGDWVIDRPGQFYAAGTQFTYKRPNEIRSRAGESITAPGPTNQELN 164

  Fly   866 LYAIVRGNESNAGIFYEFTLPALNVT--------------------------AGRQ--------- 895
            |:.|.:  :.:|.::||:.||....|                          .|..
Zfish   165 LFVIYQ--QPDAAVYYEYILPKHTNTHSDAYSYSSVLPLVESHGIFPDSENSVGENSLSSFHPNQ 227

  Fly   896 -------------FQWRLSNWTACSASCGGGVQHREPI--CQENG---KALGDTLPCWTHAKNKR 942
                         :.|.....|.||.:||.|  :|:.:  |.|..   ..|.|.....||
Zfish   228 VPSDSVTLEPVPLYSWMAMATTPCSTTCGTG--NRQVLFGCVERATQTTVLEDLCSSITH----- 285

  Fly   943 PARQSRGCGDQPCPAHWWPGPWQFCPVTCRPVGF------------------------------- 976
            |..|...|..|||||.|..|.|..|..||.| ||
Zfish   286 PGPQVEECQSQPCPAFWDVGEWSECSKTCGP-GFQYRQVICRQTQGQHGSSTVVVANSMCDDTEM 349

  Fly   977 -----------------------VAPP----QRRRSVVCLDEHDVVVADAECGHLQKPAEMEPCE 1014
                                   .:.|    ||.|.|||:|....:|:|.||....:|.:::.|:
Zfish   350 PDTTSVCQLKICSEWQIRSEWTECSVPCGVGQRSREVVCVDNLGDIVSDEECNMALRPQDLQNCD 414

  Fly  1015 SSLPIC 1020
            ..  :|
Zfish   415 KG--VC 418

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AdamTS-B	NP_572247.2	Pep_M12B_propep	78..194	CDD:279848
		ZnMc_ADAMTS_like	314..518	CDD:239801
		Reprolysin	315..521	CDD:279729
		ADAM_CR	<558..602	CDD:301627
		TSP1	614..666	CDD:214559
		ADAM_spacer1	773..886	CDD:283607	36/120 (30%)
		TSP1	901..956	CDD:214559	18/59 (31%)
adamtsl7	XP_017211532.2	ADAM_spacer1	82..183	CDD:310520	35/106 (33%)
		TSP1	302..>335	CDD:214559	9/33 (27%)
		TSP1	361..418	CDD:214559	14/58 (24%)
		TSP1	542..593	CDD:214559
		PLAC	601..631	CDD:312271
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3538
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900