DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment AdamTS-B and paplnb

DIOPT Version :9

Sequence 1:	NP_572247.2	Gene:	AdamTS-B / 31490	FlyBaseID:	FBgn0029791	Length:	1023	Species:	Drosophila melanogaster
Sequence 2:	NP_001018400.1	Gene:	paplnb / 553586	ZFINID:	ZDB-GENE-030131-6023	Length:	548	Species:	Danio rerio

Alignment Length:	408	Identity:	96/408 - (23%)
Similarity:	149/408 - (36%)	Gaps:	136/408 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   614 WGDWSEWSECSRSCGGGVSTQQRECDNPVPANGGVFCIGERKRYKICRKRPCPAEEPSFRAQQCA 678
            :|::..:..|||:|||||:.:.|.| |.:..:||..|:|..|.||:|..:.|||....||.:||:
Zfish    27 YGEYGPYGPCSRTCGGGVAVRTRIC-NTMRTDGGHNCVGPSKSYKLCNTQECPAGSRDFREEQCS 90

  Fly   679 RFDNVSYQGATYKWLPFFDKNNPCKLFCSDVDDTIIANWGATVLDGTPCTLGTNNMCIDGICKKV 743
            .||.:::||..|.|.|::..:|||:|.|....:.........|:|||.|.:|..::|::|:|:.|
Zfish    91 HFDQMTFQGKRYTWQPYYGASNPCELVCVPRGENFYYRHRPAVVDGTLCHVGRRDVCVEGVCRAV 155

  Fly   744 GCDWIVDSEVQDDRCGVCGGSGDQCQPVRETYTDPFAAKDGAYVEIVTIPARARHILIRELANSP 808
            ....||..|.:|                                    ||..:||
Zfish   156 SHGEIVGFEDRD------------------------------------IPVTSRH---------- 174

  Fly   809 HFLAIATGDGGDRFYLNGDSLISMPGEFEIAGAESLYDRVDEQETITIPQPIQHSISLYAIVRGN 873
                   |.|
Zfish   175 -------GPG------------------------------------------------------- 177

  Fly   874 ESNAGIFYEFTLPALNVTAGRQFQWRLSNWTACSASCGGGVQHREPIC-QENGKALGDTLPCWTH 937
               |.:..:            .:::..|.::.||..||||||.|...| .|...|:.|...|  .
Zfish   178 ---AAVHLD------------TYRYTYSAYSECSRLCGGGVQSRTVYCVHERTSAMVDESHC--I 225

  Fly   938 AKNKRPARQSRGCGDQPCPAHWWPGPWQFCPVTCRPVGFVAPPQRRRSVVCLDEHDVVVADAECG 1002
            ||..|.......|.:..| |.:..||:..|.|||      ....:.|.|:|:......:::..|.
Zfish   226 AKGLRKPTAQVACNEHAC-AEYSAGPFGDCSVTC------GEGLQTREVICVGGRGERLSEHHCS 283

  Fly  1003 HLQKPAEMEPCESSLPIC 1020
            .|.:|.:.:.|:.  |.|
Zfish   284 GLTRPQDTKACKR--PAC 299

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AdamTS-B	NP_572247.2	Pep_M12B_propep	78..194	CDD:279848
		ZnMc_ADAMTS_like	314..518	CDD:239801
		Reprolysin	315..521	CDD:279729
		ADAM_CR	<558..602	CDD:301627
		TSP1	614..666	CDD:214559	20/51 (39%)
		ADAM_spacer1	773..886	CDD:283607	7/112 (6%)
		TSP1	901..956	CDD:214559	19/55 (35%)
paplnb	NP_001018400.1	TSP1	28..78	CDD:214559	20/50 (40%)
		TSP1	249..300	CDD:214559	15/59 (25%)
		TSP1	309..359	CDD:214559
		Kunitz_BPTI	470..522	CDD:278443
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3538
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900