DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment AdamTS-B and ADAMTSL4

DIOPT Version :9

Sequence 1:	NP_572247.2	Gene:	AdamTS-B / 31490	FlyBaseID:	FBgn0029791	Length:	1023	Species:	Drosophila melanogaster
Sequence 2:	XP_011507946.1	Gene:	ADAMTSL4 / 54507	HGNCID:	19706	Length:	1130	Species:	Homo sapiens

Alignment Length:	473	Identity:	128/473 - (27%)
Similarity:	188/473 - (39%)	Gaps:	117/473 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   640 NPVPANGGVFCIGERKRYKICRKRPCPAEEPSFRAQQCARFDNVSYQGATYKWLPFFDK------ 698
            :|:|.     |.||.::.:.|.:.|||.|:|..||.|||.|::..:.|..|:|.||.:.
Human   392 SPIPR-----CSGESEQLRACSQAPCPPEQPDPRALQCAAFNSQEFMGQLYQWEPFTEAPLLPLR 451

  Fly   699 -------------------NNPCKLFCSDVDDTIIANWGATVLDGTPCTLGTNNMCIDGICKKVG 744
                               :..|:|.|..............|.|||.|..|..::|:.|.|...|
Human   452 HAFFLLPGAGSGDSTGVQGSQRCELNCRPRGFRFYVRHTEKVQDGTLCQPGAPDICVAGRCLSPG 516

  Fly   745 CDWIVDSEVQDDRCGVCGGSGDQCQPVRETYTDPFAAKDG--AYVEIVTIPARARHILIRELANS 807
            ||.|:.|..:.|.||||||....|:.|....||    :.|  .|.:|:.|||.|..:.|.:|..|
Human   517 CDGILGSGRRPDGCGVCGGDDSTCRLVSGNLTD----RGGPLGYQKILWIPAGALRLQIAQLRPS 577

  Fly   808 PHFLAIATGDGGDRFYLNGDSLISMPGEFEIAGAESLYDRVDEQ----ETITIPQPIQHSISLYA 868
            .::||: .|.|| |..:||:..:..||.:...|....|:|...:    |:::...|....:.:|.
Human   578 SNYLAL-RGPGG-RSIINGNWAVDPPGSYRAGGTVFRYNRPPREEGKGESLSAEGPTTQPVDVYM 640

  Fly   869 IVRGNESNAGIFYEFTLPA---------------------LNV---------------TAGRQFQ 897
            |.:  |.|.|:||::.:.:                     |.|               |..||.:
Human   641 IFQ--EENPGVFYQYVISSPPPILENPTPEPPVPQLQPEILRVEPPLAPAPRPARTPGTLQRQVR 703

  Fly   898 --------------------WRLSNWTACSASCGGGVQHREPIC--QENGKALGDTLPCWTHAKN 940
                                |:....:|||||||.||.....:|  :|:|:.| |...|   |..
Human   704 IPQMPAPPHPRTPLGSPAAYWKRVGHSACSASCGKGVWRPIFLCISRESGEEL-DERSC---AAG 764

  Fly   941 KRPARQSRGCGDQPCPAHWWPGPWQFCPVTCRPVGFVAPPQRRRSVVCLDEH---DVVVADAECG 1002
            .||......|...|||.:|..|.|..|..:|      .|..:.|.:.|..|.   ...|....||
Human   765 ARPPASPEPCHGTPCPPYWEAGEWTSCSRSC------GPGTQHRQLQCRQEFGGGGSSVPPERCG 823

  Fly  1003 HLQKPAEMEPCESSLPIC 1020
            ||.:|...:.|:  |.:|
Human   824 HLPRPNITQSCQ--LRLC 839

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AdamTS-B	NP_572247.2	Pep_M12B_propep	78..194	CDD:279848
		ZnMc_ADAMTS_like	314..518	CDD:239801
		Reprolysin	315..521	CDD:279729
		ADAM_CR	<558..602	CDD:301627
		TSP1	614..666	CDD:214559	7/25 (28%)
		ADAM_spacer1	773..886	CDD:283607	34/118 (29%)
		TSP1	901..956	CDD:214559	20/56 (36%)
ADAMTSL4	XP_011507946.1	TSP1	80..>110	CDD:214559
		ADAM_spacer1	541..655	CDD:283607	35/121 (29%)
		TSP1	783..839	CDD:214559	17/63 (27%)
		TSP1	842..897	CDD:214559
		TSP1	1033..1082	CDD:214559
		PLAC	1089..1118	CDD:285849
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	67	1.000	Domainoid score	I9779
eggNOG	1	0.900	-	-		E1_KOG3538
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.810