DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment AdamTS-B and Adamts19

DIOPT Version :9

Sequence 1:	NP_572247.2	Gene:	AdamTS-B / 31490	FlyBaseID:	FBgn0029791	Length:	1023	Species:	Drosophila melanogaster
Sequence 2:	NP_001101903.2	Gene:	Adamts19 / 361332	RGDID:	1308359	Length:	1211	Species:	Rattus norvegicus

Alignment Length:	987	Identity:	300/987 - (30%)
Similarity:	443/987 - (44%)	Gaps:	168/987 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    85 EHDTQAADLHLLLPLANETLHLELMAHSYFLAPNLVVER--------HRRDLRTRSPLTTRHLNC 141
            :.:....::.|.:|..:..|:|.|.....|||....||:        .|..:..|.|:.: ..:|
  Rat   161 QEEPSTEEVLLRIPALSRDLYLLLRRDGRFLAQRFAVEQWPKPGPDPTRATVDPRPPMPS-DASC 224

  Fly   142 HFHGKVRGQPATNVAISTC-AGLVGHIRTAGNEYFIEPSKEHEPHPVNGHPHVVFQRSSVKPKHS 205
            .:.|.|...|.:..:.||| .||:|.|:...:..||||.  ::...:.||||.:::
  Rat   225 FYTGTVLRHPGSLASFSTCGGGLMGFIQLNEDFIFIEPF--NDTMAIIGHPHRLYR--------- 278

  Fly   206 LRKRNKRKRGGKSGSGAEVSNCGTREPRRRMETRLEWQARGKVKVQGGRQIRRHHHHHHHHHHKH 270
             :||:..:|..:..:.                                       |.||......
  Rat   279 -QKRSSEERVTEKSAA---------------------------------------HRHHCGVISD 303

  Fly   271 KYRHHQQKISRVPHTKFKYETQFQTEPDHAEIPRRRR-SISSPR--HVETLIVADATMSAFH--R 330
            |.|...:|:                    ||..|.:| |...|:  ::||::|||..|.::|  .
  Rat   304 KGRPRSKKL--------------------AENRREKRYSYKLPQDYNIETVVVADPAMVSYHGAD 348

  Fly   331 DLNGYLLTIMNMVSALYKDPSIGNSIEIVVVRIIQLDEEESQLQLNLTQNAQKNLDRFCSWQHKL 395
            ....::|||:|||..|::..|:|..:.:.|:::|.|.|..:.|.:.  .:.:|.|:.||.|||:
  Rat   349 AARRFILTILNMVFNLFQHKSLGVQVNLRVIKLILLHETPADLYIG--HHGEKMLESFCKWQHE- 410

  Fly   396 NKGSEKDPHHH------------DVAILITRKNICANN---CMTLGLANVGGMCKPKQSCSVNED 445
            ..|.:.|.|..            |.|||||||:.|.:.   |.|:|:|.:.|||..|:.|.:.||
  Rat   411 EFGRKNDIHLEMSTSWGEDVASVDAAILITRKDFCVHKDEPCDTVGIAYLNGMCSEKRKCIIAED 475

  Fly   446 NGIMLSHTITHELGHNFGMFHDTAKIGCHPRVGPIVHIMTPTF--GADTLQVCWSNCSRKYITHF 508
            ||:.|:.||.||:|||.|:.||..    ||.....:|||:..:  |.:...|.||.||::.:..|
  Rat   476 NGLNLAFTIAHEMGHNMGINHDND----HPSCADGLHIMSGEWIKGQNLGDVSWSRCSKEDLERF 536

  Fly   509 LDQGLGEC-LDDPPTPLDEYNYTGELPGMRYNARGQCRLQFNLTTDSEVGAC-SAPHEFCSTLWC 571
            |......| |...|..|.......:||||.|.|..||::.|.    .....| ...|..|:.|||
  Rat   537 LRSKASSCLLHTDPQSLSSVLVPSKLPGMAYTADEQCQILFG----PLASFCQEMQHVICTGLWC 597

  Fly   572 KVNG--ECVTHMRPTAPGTLCGRNKWCQNGKCVRR----EELAAVNGGWGDWSEWSECSRSCGGG 630
            :|.|  ||.|.:.|...||.|...|||:.|:|.||    |.||      |:||.||.||||||.|
  Rat   598 RVEGDTECRTKLDPPMDGTDCDPGKWCKAGECTRRTPAPEHLA------GEWSTWSSCSRSCGSG 656

  Fly   631 VSTQQRECDNPVPANGGVF--CIGERKRYKICRKRPCPAEEPSFRAQQCARFD-NVSYQGATYKW 692
            ||:::|:|    |..|...  |.|.||:|:||...||||..|.||..||..:. ..||.....:|
  Rat   657 VSSRERKC----PGLGSEARDCNGPRKQYRICENPPCPAGLPGFRDWQCQAYSVRTSYPKHALQW 717

  Fly   693 LPFFDKNNPCKLFCSDVDDTIIANWGATVLDGTPCTLGTNNMCIDGICKKVGCDWIVDSEVQDDR 757
            ...||:..||.||||.|...........|||||.|.....::|.:|.|:|.|||.::.|..::|.
  Rat   718 QAVFDEEKPCALFCSPVGKEQPVLLSEKVLDGTSCGYQGLDVCANGRCQKAGCDGLLGSLAREDH 782

  Fly   758 CGVCGGSGDQCQPVRETYTDPFAAKDGAYVEIVTIPARARHILIRELANSPHFLAIATGDGGDRF 822
            ||||.|:|..|:.::..:..   .:...|||::.|||.||.|.:.|...:..:||:.   ...:.
  Rat   783 CGVCNGNGKSCKVIKGDFNH---TRGAGYVEVLVIPAGARRIKVVEEKPAHSYLALR---DASKQ 841

  Fly   823 YLNGDSLISMPGEFEIAGAESLYDRVDEQETITIPQPIQHSISLYAIVRGNESNAGIFYEFTLPA 887
            .:|.|..|...|.|.:||....|.|....|.|:...|....:.|..:: ..:.|.|:.||:|:|:
  Rat   842 SINSDWKIEHSGAFSLAGTTVHYIRRGLWEKISAKGPTTTPLHLLVLL-FQDQNYGLHYEYTVPS 905

  Fly   888 -------LNVTAGRQFQWRLSNWTACSASCGGGVQHREPICQENGKALGDTLPCWTHAKNK---R 942
                   .:..:|..|.|..:.|..|:|:||||.:.....|.   |.:...:....:.|.|   :
  Rat   906 DPLPDNQSSKESGPLFMWTHAGWGDCNATCGGGERKTTVSCT---KIMNKNISLVDNKKCKDLTK 967

  Fly   943 PARQSRGCGDQPCPAHWWPGPWQFCPVTCRPVGFVAPPQRRRSVVC---LDEHDVVVA-DAEC-G 1002
            |..|.|.|.:|||...|....|..|..||      ....:.|.|.|   |:...::.| :.:| |
  Rat   968 PEPQIRKCNEQPCQTRWMMTEWTTCSRTC------GKGVQSRQVACTRQLENGTLIRAWERDCIG 1026

  Fly  1003 HLQKPAEMEPCE 1014
              .|||.|:.||
  Rat  1027 --PKPATMQRCE 1036

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AdamTS-B	NP_572247.2	Pep_M12B_propep	78..194	CDD:279848	32/117 (27%)
		ZnMc_ADAMTS_like	314..518	CDD:239801	78/223 (35%)
		Reprolysin	315..521	CDD:279729	79/225 (35%)
		ADAM_CR	<558..602	CDD:301627	19/46 (41%)
		TSP1	614..666	CDD:214559	26/53 (49%)
		ADAM_spacer1	773..886	CDD:283607	30/112 (27%)
		TSP1	901..956	CDD:214559	17/57 (30%)
Adamts19	NP_001101903.2	Pep_M12B_propep	162..277	CDD:396235	32/117 (27%)
		ZnMc_ADAMTS_like	329..546	CDD:239801	78/223 (35%)
		ADAM_CR_2	563..630	CDD:407643	27/70 (39%)
		ADAM_spacer1	794..904	CDD:368694	30/116 (26%)
		TSP1_ADAMTS	928..980	CDD:408800	16/54 (30%)
		TSP1_ADAMTS	984..1040	CDD:408800	18/61 (30%)
		TSP1_ADAMTS	1044..1086	CDD:408800
		TSP1_ADAMTS	1095..1147	CDD:408800
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3538
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D125522at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820