DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment AdamTS-B and nolo

DIOPT Version :9

Sequence 1:	NP_572247.2	Gene:	AdamTS-B / 31490	FlyBaseID:	FBgn0029791	Length:	1023	Species:	Drosophila melanogaster
Sequence 2:	NP_001036374.1	Gene:	nolo / 35424	FlyBaseID:	FBgn0051619	Length:	1394	Species:	Drosophila melanogaster

Alignment Length:	455	Identity:	128/455 - (28%)
Similarity:	183/455 - (40%)	Gaps:	129/455 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   603 RREELAAVNGG---------WGDWSEWSECSRSCGGGVSTQQRECDNPVPANGGVFCIGERKRYK 658
            :|.::.:..||         |..||:||.|||:|.||:..|.|.|.:|    |.  |.||..||:
  Fly    58 KRSKVQSAGGGGGAGGGPGQWSSWSDWSTCSRTCDGGIMHQMRRCGSP----GS--CRGESTRYR 116

  Fly   659 ICRKRPCPAEEPSFRAQQCARFDNVSYQGATYKWLPFFDKNNPCKLFC--------SDV------ 709
            ||..:||| |:..||:.||:.:::|.|.|..|||.|.:|...||.|.|        .|:
  Fly   117 ICNMQPCP-EQQDFRSSQCSAYNDVPYDGTLYKWTPHYDYVEPCALTCRGHPAHLVEDISRETGD 180

  Fly   710 ----------DDTIIANWGATVLDGTPCTLGTNNMCIDGICKKVGCDWIVDSEVQDDRCGVCGGS 764
                      :.::|....|.|.|||.|..|:.:|||.|.|::||||..:.|..:.|.||||||.
  Fly   181 GNAEEAEHYDEQSVIVQLSARVQDGTRCRSGSLDMCIQGKCQRVGCDLKIGSTKKIDGCGVCGGD 245

  Fly   765 GDQC-QPVRETYTDPFAAKDGAYVEIVTIPA---RARHILIRELANSPHFLAIATGDGGDRFYLN 825
            |:.| ||:......|.:...      ||..:   .:|.|....|.|       |..|
  Fly   246 GNSCSQPLFNWEMAPMSQCS------VTCGSGYKMSRPICRNRLTN-------ADVD-------- 289

  Fly   826 GDSLISMPGEFEIAGAESLYDRVDEQETITIPQPIQHSISLYAIVRGNESNAGIFYEFTLPALNV 890
             |:|.|:....|.:        |::..|.:.|.
  Fly   290 -DTLCSVTNRPEAS--------VEQCNTHSCPP-------------------------------- 313

  Fly   891 TAGRQFQWRLSNWTACSASCGGGVQHREPICQE--NG-KALGDTLPCWTHAKNKRPARQSRGCGD 952
                  :|...:|:.||..||.|.:.|..:|.|  || |.....:.|.|   .|.|.:::  |..
  Fly   314 ------RWIADDWSTCSRLCGHGYRERMVVCAEESNGIKTRVADIMCRT---PKPPTQET--CII 367

  Fly   953 QPCPAHWWPGPWQFCPVTCRPVGFVAPPQRRRSVVCLDEHDVVVADAECGHLQKPAEMEPCESSL 1017
            :.|| ||....|..|.|:|      ....:.|.|.|......:  .|:|..|.||..|:.|.:.:
  Fly   368 EECP-HWEVEDWTGCSVSC------GQGIQMRGVECKSTDGSL--SAKCDPLTKPGSMQQCSTGI 423

Fly 1018 1017
Fly 424 423

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AdamTS-B	NP_572247.2	Pep_M12B_propep	78..194	CDD:279848
		ZnMc_ADAMTS_like	314..518	CDD:239801
		Reprolysin	315..521	CDD:279729
		ADAM_CR	<558..602	CDD:301627
		TSP1	614..666	CDD:214559	24/51 (47%)
		ADAM_spacer1	773..886	CDD:283607	16/115 (14%)
		TSP1	901..956	CDD:214559	17/57 (30%)
nolo	NP_001036374.1	TSP1	78..124	CDD:214559	24/51 (47%)
		TSP1	546..600	CDD:214559
		TSP1	750..807	CDD:214559
		IGc2	845..902	CDD:197706
		PLAC	1355..1384	CDD:285849
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3538
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR13723
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.910