DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment AdamTS-B and ADAMTSL5

DIOPT Version :9

Sequence 1:	NP_572247.2	Gene:	AdamTS-B / 31490	FlyBaseID:	FBgn0029791	Length:	1023	Species:	Drosophila melanogaster
Sequence 2:	XP_011526263.1	Gene:	ADAMTSL5 / 339366	HGNCID:	27912	Length:	485	Species:	Homo sapiens

Alignment Length:	428	Identity:	127/428 - (29%)
Similarity:	174/428 - (40%)	Gaps:	86/428 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   557 GACSAPHEFCST---LWCKVNGECVTHMRPTAPGTLCGRNKWCQNGKCVRREELAAVNGGWGDWS 618
            |....||.|.:.   ||..:|               ||.....|.            .|.|..|.
Human    15 GHTERPHLFQNLLLFLWALLN---------------CGLGVSAQG------------PGEWTPWV 52

  Fly   619 EWSECSRSCGGGVSTQQREC-----DNPVPANGGVFCIGERKRYKICRKRPCPAEEPSFRAQQCA 678
            .|:.||.|||.|||.:.|.|     :.|        |.|:...|::|:...||.....||..|||
Human    53 SWTRCSSSCGRGVSVRSRRCLRLPGEEP--------CWGDSHEYRLCQLPDCPPGAVPFRDLQCA 109

  Fly   679 RFDNVSYQGA--TYKWLPFFDKNNPCKLFCSDVDDTIIANWGATVLDGTPCTLGTNNMCIDGICK 741
            .::.....|.  ||:|:||....|.|.|.|.........::| .|||||.|:.|...:|:.|.|.
Human   110 LYNGRPVLGTQKTYQWVPFHGAPNQCDLNCLAEGHAFYHSFG-RVLDGTACSPGAQGVCVAGRCL 173

  Fly   742 KVGCDWIVDSEVQDDRCGVCGGSGDQCQPVRETYTDPFAAKDGAYVEIVTIPARARHILIRELAN 806
            ..|||.::.|...:||||.|||:.|.|..|:..:.|  |.....|..:..||..||||.:...:.
Human   174 SAGCDGLLGSGALEDRCGRCGGANDSCLFVQRVFRD--AGAFAGYWNVTLIPEGARHIRVEHRSR 236

  Fly   807 SPHFLAIATGDGGD-RFYLNGDSLISMPGEFEIAGAESLYDR-VDEQETITIPQPIQHSISLYAI 869
            : |...:.:..||| |:.|||..::|.||.:|.||...:|.| ...|||:....|..|.:.|..:
Human   237 N-HLGILGSLMGGDGRYVLNGHWVVSPPGTYEAAGTHVVYTRDTGPQETLQAAGPTSHDLLLQVL 300

  Fly   870 VRGNESNAGIFYEFTLPALNVTAGRQFQWRLS--NWTACSASCGGGVQHREPICQENGKALGDTL 932
            ::  |.|.||.:||.||....:   .||.|:.  .|               |:.|...:.:....
Human   301 LQ--EPNPGIEFEFWLPRERYS---PFQARVQALGW---------------PLRQPQPRGVEPQP 345

  Fly   933 PCWTHAKNKRPARQSRGCGDQPCPAHWWPGPWQFCPVT 970
            |.   |....|| |:......|||.         ||.|
Human   346 PA---APAVTPA-QTPTLAPDPCPP---------CPDT 370

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AdamTS-B	NP_572247.2	Pep_M12B_propep	78..194	CDD:279848
		ZnMc_ADAMTS_like	314..518	CDD:239801
		Reprolysin	315..521	CDD:279729
		ADAM_CR	<558..602	CDD:301627	9/46 (20%)
		TSP1	614..666	CDD:214559	18/56 (32%)
		ADAM_spacer1	773..886	CDD:283607	37/114 (32%)
		TSP1	901..956	CDD:214559	9/56 (16%)
ADAMTSL5	XP_011526263.1	TSP1	48..97	CDD:214559	18/56 (32%)
		ADAM_CR	<106..174	CDD:301627	24/68 (35%)
		ADAM_spacer1	206..315	CDD:283607	37/113 (33%)
		NTR_like	379..480	CDD:239600
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	67	1.000	Domainoid score	I9779
eggNOG	1	0.900	-	-		E1_KOG3538
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.810