DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment AdamTS-B and Adamts3

DIOPT Version :9

Sequence 1:	NP_572247.2	Gene:	AdamTS-B / 31490	FlyBaseID:	FBgn0029791	Length:	1023	Species:	Drosophila melanogaster
Sequence 2:	NP_808540.2	Gene:	Adamts3 / 330119	MGIID:	3045353	Length:	1204	Species:	Mus musculus

Alignment Length:	1148	Identity:	321/1148 - (27%)
Similarity:	462/1148 - (40%)	Gaps:	275/1148 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 LLLHYWLVVVT----------QGGGVRPLYGLHSDELVA--------GEGQLVVPRRVHPDGAFM 61
            :.|..||:..:          |.|         :||:|.        .|.:||.|...:..|.::
Mouse     2 VFLSLWLIAASLVEVRTSADGQAG---------TDEMVQIDLPTKRYREYELVTPVSTNLKGHYL 57

  Fly    62 THQLEYAHELDHRRHRQRRSLNSEHDTQAADLHLLLPLANETLHLELMAHSYFLAPNLVVERHRR 126
            :|.|...|:   :|..:..|.||||      |...:.......||.|..:::|:||..|||.|
Mouse    58 SHILSANHK---KRSPRDVSSNSEH------LFFNVTAFGRDFHLRLKPNTHFIAPGAVVEWH-- 111

  Fly   127 DLRTRSPLTTRHLNCHFHGK--------------------VRGQPATNVAISTCAGLVGHIRTAG 171
            :...|...||...|.|.||.                    :...|.|:||||.|.||.|.|::..
Mouse   112 ETAPRPGNTTDPRNSHLHGSASEGSWRSEPLQTSCAYVGDIMDIPGTSVAISNCDGLAGMIKSDD 176

  Fly   172 NEYFIEP-SKEHEPHPVNGHPHVVFQRSSV-KPKHSLRK---RNKRKRGGKSGSGAEVSNCGTRE 231
            .|||||| .:..:....||..|||::||:| :|...:.:   ..:....|....|...||.|
Mouse   177 EEYFIEPLERGKQMDEENGRIHVVYKRSAVEQPPRDVSEDVYHRESDLEGLDDLGTVYSNIG--- 238

  Fly   232 PRRRMETRLEWQARGKVKVQGGRQIRRHHHHHHHHHHKHKYRHHQQKISRVPHTKFKYETQFQTE 296
                                                         |::::.
Mouse   239 ---------------------------------------------QQLNKT-------------- 244

  Fly   297 PDHAEIPRRRRSISSPRHVETLIVADATMSAFH--RDLNGYLLTIMNMVSALYKDPSIGNSIEIV 359
                 :.|||.:..:..::|.|:..|.::..||  ..:..||||:||:|:.:|.|.|:|..|.:|
Mouse   245 -----MRRRRHTGENDYNIEVLLGVDDSVVRFHGKEHVQNYLLTLMNIVNEIYHDESLGVHINVV 304

  Fly   360 VVRIIQLDEEESQLQLNLTQNAQKNLDRFCSWQHKLNKGSEKDPHHHDVAILITRKNICANNCMT 424
            :||:|.|...:| :.|....|..::|:..|.|..:..|.......|||.||.:||::.......
Mouse   305 LVRMIMLGYAKS-ISLIERGNPSRSLENVCRWACQQQKTDPNHAEHHDHAIFLTRQDFGPAGMQ- 367

  Fly   425 LGLANVGGMCKPKQSCSVNEDNGIMLSHTITHELGHNFGMFHDTA--KIGCHPRVGPIVHIMTPT 487
             |.|.|.|||.|.:||::|.::|...:..:.||.||..||.||..  :.|....:|   .:|.|.
Mouse   368 -GYAPVTGMCHPVRSCTLNHEDGFSSAFVVAHETGHVLGMEHDGQGNRCGDETAMG---SVMAPL 428

  Fly   488 FGADTLQVCWSNCS----RKYITHFLDQGLGECLDDPPTPLDEYNYTGELPGMRYNARGQCRLQF 548
            ..|...:..||.||    ::||..:      :||.|.|...| :....||||:.|:...|||..|
Mouse   429 VQAAFHRYHWSRCSGQELKRYIHSY------DCLLDDPFEHD-WPKLPELPGINYSMDEQCRFDF 486

  Fly   549 NLTTDSEVG--ACSAPHEF--CSTLWCKVNGE---CVTHMRPTAPGTLCGRNKWCQNGKCV-RRE 605
            .      ||  .|:|...|  |..|||.....   |.|...|...||.|...|||..|.|: :..
Mouse   487 G------VGYKMCTAFRTFDPCKQLWCSHPDNPYFCKTKKGPPLDGTECAAGKWCYKGHCMWKNA 545

  Fly   606 ELAAVNGGWGDWSEWSECSRSCGGGVSTQQRECDNPVPANGGVFCIGERKRYKICRKRPCPAEEP 670
            .....:|.||.|:::..|||:||.||..:.|:|:||.|.|||..|.|....|::|....|.....
Mouse   546 NQQKQDGNWGSWTKFGSCSRTCGTGVRFRTRQCNNPTPINGGQDCPGVNFEYQLCNTEECQKHFE 610

  Fly   671 SFRAQQC-ARFDNVSYQGATYKWLPFF--DKNNPCKLFCSDVDDTIIANWGATVLDGTPCTL-GT 731
            .|||||| .|..:..||...:.|||..  |....|.|:|...:...:|.....|.|||.|:. ..
Mouse   611 DFRAQQCQQRNSHFDYQNTKHHWLPHEHPDSKKRCHLYCQSKETGDVAYMKQLVHDGTRCSYKDP 675

  Fly   732 NNMCIDGICKKVGCDWIVDSEVQDDRCGVCGGSGDQCQPVRETYT---DPFAAKDGAYVEIVTIP 793
            .::|:.|.|.|||||..:.|...:|:||||||....|:.|:.|:|   .......||:|    :|
Mouse   676 YSICVRGECVKVGCDREIGSNKVEDKCGVCGGDNSHCRTVKGTFTRTPRKLGKTRGAFV----LP 736

  Fly   794 ARARHILIRELANSPHFLAI---ATGDGGDRFYLNGDSLISMPGEFEIAGAESLYDRVDEQETIT 855
            ..||:|.:.|...:.:.|||   |||    .:.|||....:....|...|.|..|:..|:.||:.
Mouse   737 KGARNISLAETRETKNVLAIKNQATG----HYILNGKGEEAKSRTFIDLGVEWDYNIEDDIETLH 797

  Fly   856 IPQPIQHSISLYAIVRGNESNAGIFYEF-----TLPALNVTAGRQ-----FQWRLSNWTACSASC 910
            ...|:...:.:..|.:.|::.:.:.|::     ::|.:|.....|     |:|.|.:|:.||..|
Mouse   798 TDGPLHDPVIVLIIPQENDTRSSLTYKYIIHEDSVPTINSNNVIQEELDTFEWALKSWSQCSEPC 862

  Fly   911 GGGVQ---------------HREPICQENGK---------ALGDTLPCW---------------- 935
            |||.|               ||. .|:.|.|         ....|.|.|
Mouse   863 GGGFQYTKYGCRRKSDSKMVHRS-FCEVNKKPKPIRRMCNIQECTHPVWAADEWEHCSRSCGSSG 926

  Fly   936 -------------------THAK---NKRPARQSRGCGDQPCPAHWWPGPWQFCPVTCRPVGFVA 978
                               .|:|   ..|| ...|.|...||||.|..|.|..|.|||      .
Mouse   927 NQLRTVRCLQPLQDGTNRSVHSKYCLGDRP-ESRRPCNRVPCPAQWKTGSWNECSVTC------G 984

  Fly   979 PPQRRRSVVC-LDEHDVVVADAECGHLQKPAEMEPCESSLPIC 1020
            .....|.|:| ..:|    .|.|     ||..:.||:  ||.|
Mouse   985 EGTEVRQVLCRTGDH----CDGE-----KPESVRPCQ--LPPC 1016

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AdamTS-B	NP_572247.2	Pep_M12B_propep	78..194	CDD:279848	43/136 (32%)
		ZnMc_ADAMTS_like	314..518	CDD:239801	67/211 (32%)
		Reprolysin	315..521	CDD:279729	69/213 (32%)
		ADAM_CR	<558..602	CDD:301627	17/48 (35%)
		TSP1	614..666	CDD:214559	22/51 (43%)
		ADAM_spacer1	773..886	CDD:283607	30/123 (24%)
		TSP1	901..956	CDD:214559	23/116 (20%)
Adamts3	NP_808540.2	Pep_M12B_propep	66..200	CDD:279848	44/144 (31%)
		ZnMc_ADAMTS_like	256..457	CDD:239801	67/212 (32%)
		Reprolysin	258..460	CDD:279729	69/213 (32%)
		TSP1	554..605	CDD:214559	22/50 (44%)
		ADAM_spacer1	713..828	CDD:283607	31/122 (25%)
		TSP1	914..968	CDD:214559	7/54 (13%)
		TSP1	971..1016	CDD:214559	19/61 (31%)
		PLAC	1024..1052	CDD:285849
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3538
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810