DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment AdamTS-B and Adamts20

DIOPT Version :9

Sequence 1:	NP_572247.2	Gene:	AdamTS-B / 31490	FlyBaseID:	FBgn0029791	Length:	1023	Species:	Drosophila melanogaster
Sequence 2:	XP_038936261.1	Gene:	Adamts20 / 315263	RGDID:	1307725	Length:	1928	Species:	Rattus norvegicus

Alignment Length:	1188	Identity:	335/1188 - (28%)
Similarity:	488/1188 - (41%)	Gaps:	303/1188 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 SRWLGLLLHYWLVVVTQGGGVRPLYGLHSDELV--AGEGQLVVPRRVHPDGAFMTHQLEYAHELD 72
            ::||..||....:::|....||  :....:.||  ....::|.|.||:          |:.....
  Rat     4 AKWLTGLLCPISLLLTGSWEVR--FHPRQEALVKTLASYEVVTPTRVN----------EFGDVFP 56

  Fly    73 HRRH--RQRRSLNSEHDTQAADLHLLLPLANETLHLELMAHSYFLAPNLVVERHRRDL------R 129
            ..||  |::|| :...:......|..:....:...|.|.|.|.|||.. ..|.|....      |
  Rat    57 QNRHFSRKKRS-SGVPEPPPLRTHYRISAYGQLFQLNLSADSAFLAAG-YTEVHLGTPVPGPGGR 119

  Fly   130 TRSPLTTRHLNCHFHGKVRGQPATNVAISTCAGLVGHIRTAGNEYFIEP-----SKEHEPHPVNG 189
            :..|...||  |.:.|:|..:.......|.|.||:|..:....|||:||     ..|||..  :.
  Rat   120 SAEPPDLRH--CFYRGQVNAREDHIAVFSLCGGLMGTFKANDGEYFLEPVLKADGSEHEDD--HN 180

  Fly   190 HPHVVFQRSSVKPKHSLRKRNKRKRGGKSGSGAEVSNCGTREPRRRMETRLEWQARGKVKVQGGR 254
            .||:::::..        |||...|....|.      ||..|
  Rat   181 KPHLIYRQEV--------KRNAFVRSQSHGP------CGVSE----------------------- 208

  Fly   255 QIRRHHHHHHHHHHKHKYRHHQQKISRVPHTKFKYET---------QFQTEPDHAEI-PRRRRSI 309
                                :|.:.:.:|...|:..|         .|..|.:.:.: .|.:|.:
  Rat   209 --------------------NQTEKTALPSPSFRNTTGDLNRRKGAVFGLEGERSRLHSRSKRFL 253

  Fly   310 SSPRHVETLIVADATMSAFH-RDLNGYLLTIMNMVSALYKDPSIGNSIEIVVVRIIQLDEEESQL 373
            |.||:||.::.|||.|...| ::|..|:||:|::|:|:|||.||||.|.||:|:::.:..|:...
  Rat   254 SYPRYVEVMVTADAKMVRHHGQNLQHYVLTLMSIVAAIYKDSSIGNLINIVIVKLVIIHSEQEGP 318

  Fly   374 QLNLTQNAQKNLDRFCSWQHKLNKGSEKDPHHHDVAILITRKNICA--NNCMTLGLANVGGMCKP 436
            .::.  ||...|..||.||...|...:..|.|||.|:||||::||.  ..|.|||||.:|.:|.|
  Rat   319 VISF--NAATTLRNFCLWQQSQNVLDDAHPSHHDTAVLITREDICGAKEKCDTLGLAELGTLCDP 381

  Fly   437 KQSCSVNEDNGIMLSHTITHELGHNFGMFHDTAKIGC------HPRVGPIVHIMTPTFGADTLQV 495
            .:|||::|:||:..:.||.|||||.|.:.||.: ..|      |.     .|:|.||....|...
  Rat   382 SRSCSISEENGLSAAFTIAHELGHVFNVPHDDS-FKCKESGTKHQ-----YHVMAPTLNYHTSPW 440

  Fly   496 CWSNCSRKYITHFLDQGLGECLDDPPTPLDEYNYTGELPGMRYNARGQCRLQFNLTTDSEVGACS 560
            .||.||:|:||.|||.|.||||.|.|.. ..|:.:.:|||..|:...||.|.|.      .|:..
  Rat   441 TWSACSQKHITEFLDTGHGECLLDKPNG-RTYDLSPQLPGSVYDGNKQCELMFG------PGSQV 498

  Fly   561 APH-EFCSTLWCK----VNGECVTHMRPTAPGTLCGRNKWCQNGKCVRRE-ELAAVNGGWGDWSE 619
            .|: :.|..|||.    |:..|.|...|.|.||.||....|..|.||.|: |...|:|.||.|..
  Rat   499 CPYLKQCRRLWCTSAEGVHKGCRTQHMPLADGTSCGPGMHCHRGLCVTRDMETRPVDGEWGPWGP 563

  Fly   620 WSECSRSCGGGVSTQQRECDNPVPANGGVFCIGERKRYKICRKRPCPAEEPSFRAQQCARFD--- 681
            :|.|||:||||:.:..|.||.|.|.|||.:|:|.|.:::.|....||..:..||.:||:.||
  Rat   564 YSSCSRTCGGGIRSTARLCDRPEPRNGGRYCVGRRMKFRSCNTDSCPKGKRDFREKQCSDFDGKH 628

  Fly   682 -NVSYQGATYKWLPFFD---KNNPCKLFCSDVDDTIIANWGATVLDGTPCTLGTNNMCIDGICKK 742
             ::|......:|||.:.   ..:.|||:|.....|........|.|||||...||::|:.|:|::
  Rat   629 FDISGLPPNVRWLPKYSGIAVKDRCKLYCRVAGTTSFYQLKDRVADGTPCGTETNDICVQGLCRQ 693

  Fly   743 VGCDWIVDSEVQDDRCGVCGGSGDQCQPVRETYTDPFAAKDGAYVEIVTIPARARHILIRELANS 807
            .|||.:::|:.:.|:||||||....||    |....|.:....|..:|.|||.|.:|.|.:.:.|
  Rat   694 AGCDHVLNSKAKRDKCGVCGGDNSSCQ----TLAGVFNSAHYGYNVVVKIPAGATNIEILQHSYS 754

  Fly   808 -----PHFLAIATGDGGDRFYLNGDSLISMPGE--------FEIAGAESLYDRVDEQETITIPQP 859
                 .::||::...|  .|.|||:.::||..:        ||.:|:.:..:|::..:.
  Rat   755 GRPEDDNYLALSDTQG--NFLLNGNFVVSMAKKEINIQGAVFEYSGSNNSIERINSTDR------ 811

  Fly   860 IQHSISLYAIVRGNESNAGIFYEFTLP-------------------------------------- 886
            ::..:.|..:..||..|..:.|.|.:|
  Rat   812 LEAELVLQVLCVGNLYNPDVHYIFNIPIEERSNLFSWDPYGPWQDCTKMCQGLHRRKIACIRKSD 876

  Fly   887 ------------------------------------------------------------ALNVT 891
                                                                        ...|.
  Rat   877 RAVVSDQSCSHLPLPLFVTERCNTDCELRWHITGKSDCSSQCGQGYRTLDVHCMKYSVHKGQTVP 941

  Fly   892 AGRQF--------------------QWRLSNWTACSASCGGGVQHREPICQENGKALGDTLPCWT 936
            .|.|:                    :|..|.|:.||.|||||.:.||..| .||         :.
  Rat   942 VGDQYCGDQLKPPNREPCHGSCVLTRWHYSEWSQCSRSCGGGEKTRESYC-VNG---------FG 996

  Fly   937 HAKNKRPARQ-----SRGCGDQPCPAHWWPGPWQFCPVTCRPVGFVAPPQRRRSVVCLDEHDVVV 996
            |...:|..::     ...|.|.|||. |....|..|||||      ....::|.|.|....| .|
  Rat   997 HRLAERECQELPRVVLGNCNDFPCPG-WATSEWSECPVTC------GKGMKQRQVWCQRSED-PV 1053

  Fly   997 ADAECGHLQKPAEMEPCE 1014
            .|..|....||..:.|||
  Rat  1054 GDDFCDASTKPESLGPCE 1071

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AdamTS-B	NP_572247.2	Pep_M12B_propep	78..194	CDD:279848	34/126 (27%)
		ZnMc_ADAMTS_like	314..518	CDD:239801	91/212 (43%)
		Reprolysin	315..521	CDD:279729	93/214 (43%)
		ADAM_CR	<558..602	CDD:301627	16/48 (33%)
		TSP1	614..666	CDD:214559	23/51 (45%)
		ADAM_spacer1	773..886	CDD:283607	30/125 (24%)
		TSP1	901..956	CDD:214559	19/59 (32%)
Adamts20	XP_038936261.1	Pep_M12B_propep	41..186	CDD:396235	42/160 (26%)
		ZnMc_ADAMTS_like	257..463	CDD:239801	92/213 (43%)
		ADAM_CR_2	478..545	CDD:407643	24/72 (33%)
		TSP1	558..610	CDD:214559	23/51 (45%)
		ADAM_spacer1	720..838	CDD:368694	31/129 (24%)
		TSP1_ADAMTS	906..959	CDD:408800	3/52 (6%)
		TSP1_ADAMTS	968..1020	CDD:408800	19/61 (31%)
		TSP1_ADAMTS	1023..1075	CDD:408800	19/56 (34%)
		TSP1_ADAMTS	1078..1132	CDD:408800
		TSP1_ADAMTS	1154..1206	CDD:408800
		TSP1_ADAMTS	1209..1261	CDD:408800
		TSP1_ADAMTS	1306..1357	CDD:408800
		TSP1_ADAMTS	1360..1412	CDD:408800
		TSP1_ADAMTS	1418..1471	CDD:408800
		TSP1_ADAMTS	1474..1527	CDD:408800
		TSP1_ADAMTS	1532..1585	CDD:408800
		TSP1_ADAMTS	1657..1708	CDD:408800
		GON	1713..1880	CDD:400843
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D125522at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100241
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820