DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment AdamTS-B and Adamts10

DIOPT Version :9

Sequence 1:	NP_572247.2	Gene:	AdamTS-B / 31490	FlyBaseID:	FBgn0029791	Length:	1023	Species:	Drosophila melanogaster
Sequence 2:	NP_001258374.1	Gene:	Adamts10 / 314655	RGDID:	1598320	Length:	1104	Species:	Rattus norvegicus

Alignment Length:	1056	Identity:	344/1056 - (32%)
Similarity:	488/1056 - (46%)	Gaps:	176/1056 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 WLVVVTQGGGVRPLYGLHS-DELVAG--EGQLVVPRRVHPDGAFMTHQLEYAHELDHRRHRQRRS 81
            |.:.:..|...:..:...| |||::.  ..::..|.||..:||.:...       .....||||.
  Rat    10 WALALGLGLTFKVTHAFRSQDELLSSLESYEIAFPTRVDHNGAMLAFS-------PPALRRQRRG 67

  Fly    82 LNSEHDTQAADLHLLLPLANETLH--LELMAHSYFLAPNLVVERHRRDLRTRSPLTTRHLNCHFH 144
            :.:     ||:..|...:|..:.|  |.|......||.::.||...|:..........|  |.:.
  Rat    68 VGA-----AAESRLFYKVAAPSTHFLLNLTRSPRLLAGHVSVEYWTREGLAWQRAARAH--CLYA 125

  Fly   145 GKVRGQP-ATNVAISTCAGLVGHIRTAGNEYFIEP---SKEHEPHPVNGHPHVVFQRSSVKPKHS 205
            |.::||. :::||||||.||.|.|.....||.|||   ..:....|....||||::|||::..|.
  Rat   126 GHLQGQAGSSHVAISTCGGLHGLIVADDEEYLIEPLQGGPKGRRGPEESGPHVVYKRSSLRHPHL 190

  Fly   206 LRKRNKRKRGGKSGSGAEVSNCGTREPRRRMETRLEWQAR---------GKVKVQGGRQIRRHHH 261
                              .:.||.|:.:       .|:.|         ...:.||.
  Rat   191 ------------------DTACGVRDEK-------PWKGRPWWLRTLKPPPARPQGN-------- 222

  Fly   262 HHHHHHHKHKYRHHQQKISRVPHTKFKYETQFQTEPDHAEIPRRRRSISSPRHVETLIVADATMS 326
                                            :||.....:   :||:|..|:||||:|||..|.
  Rat   223 --------------------------------ETERGQLGL---KRSVSRERYVETLVVADKMMV 252

  Fly   327 AFH--RDLNGYLLTIMNMVSALYKDPSIGNSIEIVVVRIIQLDEEESQLQLNLTQNAQKNLDRFC 389
            |:|  ||:..|:|.|||:|:.|::|.|:||.:.|:|.|:|.|.|::..|:  :|.:|.|:||.||
  Rat   253 AYHGRRDVEQYVLAIMNIVAKLFQDSSLGNIVNILVTRLILLTEDQPTLE--ITHHAGKSLDSFC 315

  Fly   390 SWQHKL-------NKGSEKDPHHHDVAILITRKNICA---NNCMTLGLANVGGMCKPKQSCSVNE 444
            .||..:       |...|....:||.|:||||.:||.   ..|.|||||.|||||:.::|||:||
  Rat   316 KWQKSIVSHSGHGNAIPENGVANHDTAVLITRYDICIYKNKPCGTLGLAPVGGMCERERSCSINE 380

  Fly   445 DNGIMLSHTITHELGHNFGMFHDTAKIGCHPRVGPIVHIMTPTFGADTLQVCWSNCSRKYITHFL 509
            |.|:..:.||.||:||.|||.||....||..|......:|.......|....||:|||.|||.||
  Rat   381 DIGLATAFTIAHEIGHTFGMNHDGVGNGCGARGQDPAKLMAAHITMKTNPFVWSSCSRDYITSFL 445

  Fly   510 DQGLGECLDDPPTPLDEYNYTGELPGMRYNARGQCRLQFNL-TTDSEVGACSAPHEFCSTLWC-K 572
            |.|||.||::.| |..::.|....||..|:|..|||.|..: :...:.|      |.||.||| .
  Rat   446 DSGLGLCLNNRP-PRQDFVYPTVAPGQAYDADEQCRFQHGVKSRQCKYG------EVCSELWCLS 503

  Fly   573 VNGECVTHMRPTAPGTLCGRNK----WCQNGKCV---RREELAAVNGGWGDWSEWSECSRSCGGG 630
            .:..|:|:..|.|.||||..:.    ||....||   .|.|  .|:|.||.|:.|.:||||||||
  Rat   504 KSNRCITNSIPAAEGTLCQTHTIDKGWCYKRVCVPFGSRPE--GVDGAWGPWTPWGDCSRSCGGG 566

  Fly   631 VSTQQRECDNPVPANGGVFCIGERKRYKICRKRPCPAEEPSFRAQQCARFDNVSYQGATYKWLPF 695
            ||:..|.||:|.|..||.:|:|||:|::.|....||.....||..||:.||:|.::|..|.|..:
  Rat   567 VSSSSRHCDSPRPTIGGKYCLGERRRHRSCNTNDCPPGSQDFREMQCSEFDSVPFRGKFYTWKTY 631

  Fly   696 FDKN-NPCKLFCSDVDDTIIANWGATVLDGTPCTLGTNNMCIDGICKKVGCDWIVDSEVQDDRCG 759
            .... ..|.|.|............|.|:|||||...|.::|:.|.||.||||.::.|::::|:|.
  Rat   632 RGGGVKACSLTCLADGFNFYTERAAAVVDGTPCRPDTVDICVSGECKHVGCDRVLGSDLREDKCR 696

  Fly   760 VCGGSGDQCQPVRETYTDPFAAKDGAYVEIVTIPARARHILIRELANSPHFLAIATGDGGDRFYL 824
            ||||.|..|:.:...::.  |.....|.::|.||..:.||.|::|..|...||: .|| .:...|
  Rat   697 VCGGDGSACETIEGVFSP--ALPGTGYEDVVWIPKGSVHIFIQDLNLSLSHLAL-KGD-QESLLL 757

  Fly   825 NGDSLISMPGEFEIAGAE-SLYDRVDEQETITIPQPIQHSISLYAIVRGNESNAGIFYEFTLPAL 888
            .|....|.|....:||.. .|....|:.:::....||..|:.:..:.:..           ||||
  Rat   758 EGLPGTSQPHRLPLAGTTFHLRQGPDQAQSLEALGPINASLIIMVLAQAE-----------LPAL 811

  Fly   889 ----NVTAGRQ----FQWRLSNWTACSASCGGGVQHREPIC--QENGKALGDTLPCWTHAKNKRP 943
                |....|.    :.|..:.||.|||.|.||.|.:...|  |.:..|:.   |.:..|.:|.|
  Rat   812 RYRFNAPIARDALPPYSWHYAPWTKCSAQCAGGSQVQVVECRNQLDSSAVA---PHYCSAHSKLP 873

  Fly   944 ARQSRGCGDQPCPAHWWPGPWQFCPVTCRPVGFVAPPQRRRSVVCLDE----HDVVVADAECGHL 1004
            .|| |.|..:|||..|..|.|..|..:| ..|.     |.|||||...    .:..:.|:.|..
  Rat   874 KRQ-RACNTEPCPPDWVVGNWSRCSRSC-DAGV-----RSRSVVCQRRVSAAEEKALDDSACPQ- 930

  Fly  1005 QKPAEMEPCESSLPIC 1020
            .:|..:|.|:.  |:|
  Rat   931 PRPPVLEACQG--PMC 944

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AdamTS-B	NP_572247.2	Pep_M12B_propep	78..194	CDD:279848	38/121 (31%)
		ZnMc_ADAMTS_like	314..518	CDD:239801	99/215 (46%)
		Reprolysin	315..521	CDD:279729	100/217 (46%)
		ADAM_CR	<558..602	CDD:301627	16/48 (33%)
		TSP1	614..666	CDD:214559	27/51 (53%)
		ADAM_spacer1	773..886	CDD:283607	25/113 (22%)
		TSP1	901..956	CDD:214559	21/56 (38%)
Adamts10	NP_001258374.1	Pep_M12B_propep	40..180	CDD:396235	45/153 (29%)
		ZnMc_ADAMTS_like	239..454	CDD:239801	100/216 (46%)
		ADAM_CR_2	469..537	CDD:407643	25/73 (34%)
		TSP1	550..602	CDD:214559	27/51 (53%)
		ADAM_spacer1	706..818	CDD:368694	30/126 (24%)
		TSP1_ADAMTS	829..884	CDD:408800	21/58 (36%)
		TSP1_ADAMTS	888..944	CDD:408800	18/64 (28%)
		TSP1_ADAMTS	948..1002	CDD:408800
		TSP1_ADAMTS	1007..1057	CDD:408800
		PLAC	1070..1102	CDD:400844
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	216	1.000	Domainoid score	I2619
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D125522at2759
OrthoFinder	1	1.000	-	-		FOG0001196
OrthoInspector	1	1.000	-	-		otm44747
orthoMCL	1	0.900	-	-		OOG6_100241
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.820