DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment AdamTS-B and Adamts9

DIOPT Version :9

Sequence 1:	NP_572247.2	Gene:	AdamTS-B / 31490	FlyBaseID:	FBgn0029791	Length:	1023	Species:	Drosophila melanogaster
Sequence 2:	NP_001101347.1	Gene:	Adamts9 / 312566	RGDID:	1306889	Length:	1880	Species:	Rattus norvegicus

Alignment Length:	1182	Identity:	326/1182 - (27%)
Similarity:	468/1182 - (39%)	Gaps:	360/1182 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    45 EGQLVVPRRVHPDGAFMTHQLEYAHELDHRRHRQRRSLNSEHD------------TQAADLHLLL 97
            |.::..|.||:|.|......:.:        .|:|||:||..|            :.::..|..|
  Rat    47 EYEIASPIRVNPLGEPFPTNVHF--------KRRRRSINSASDPWPAFASSSSSSSTSSQEHYRL 103

  Fly    98 PLANETLHLELMAHSYFLAPNLVVER------HRRDLRTRSPLTTRHLNCHFHGKVRGQPATNVA 156
            ....:.....|.||:.|:||...|..      ::..|.:...:..||  |.:.|.|..:......
  Rat   104 KAFGQQFLFNLTAHTGFIAPLFTVTLLGEPGVNQSKLYSEEEMELRH--CFYKGHVNTKSEHTAV 166

  Fly   157 ISTCAGLVGHIRTAGNEYFIEP---SKEHEPHPVNGHPHVVFQR--------------------- 197
            ||.|:|::|..|:...:|||||   ..|.|.......|||:::|
  Rat   167 ISLCSGMMGTFRSHDGDYFIEPLLSVDEQEDEEEQNKPHVIYRRNNPQREPSTGKHACDTSELKN 231

  Fly   198 --SSVKPKHSLRKRNKR----------KRG--GKSGSGAEVSNCGTREPRRRMETRLEWQARGKV 248
              |..|.|..||||.||          |||  .|:.||......|||:
  Rat   232 SYSKDKRKTRLRKRRKRNSLADDVAALKRGMATKAFSGYNNRTNGTRD----------------- 279

  Fly   249 KVQGGRQIRRHHHHHHHHHHKHKYRHHQQKISRVPHTKFKYETQFQTEPDHAEIPRRRRSISSPR 313
                    ||:|                                          .|.:|.:|.||
  Rat   280 --------RRNH------------------------------------------KRTKRFLSYPR 294

  Fly   314 HVETLIVADATMSAFH-RDLNGYLLTIMNMVSALYKDPSIGNSIEIVVVRIIQLDEEESQLQLNL 377
            .||.::|||..|..:| .:|..|:||:|::|:::|||.||||.|.||:|.::.:..|:....:|.
  Rat   295 FVEVMVVADHRMVLYHGSNLQHYILTLMSIVASIYKDSSIGNLINIVIVNLVVIHNEQEGPSINF 359

  Fly   378 TQNAQKNLDRFCSWQHKLNKGSEKDPH----HHDVAILITRKNIC--ANNCMTLGLANVGGMCKP 436
              |||..|..||.|||..|       |    .||.|:|:||::||  .:.|.|||||.:|.:|.|
  Rat   360 --NAQTTLKNFCQWQHSKN-------HLGGIQHDTAVLVTREDICRAQDKCDTLGLAELGTICDP 415

  Fly   437 KQSCSVNEDNGIMLSHTITHELGHNFGMFHDTAKIGCHPRVGPIVHIMTPTFGADTLQVCWSNCS 501
            .:|||::||:|:..:.||.|||||.|.|.||.:.......|....|:|.||....|....||.||
  Rat   416 YRSCSISEDSGLSTAFTIAHELGHVFNMPHDDSNKCKEEGVKSPQHVMAPTLNFYTNPWMWSKCS 480

  Fly   502 RKYITHFLDQGLGECLDDPPTPLDEYNYTGELPGMRYNARGQCRLQFNLTTDSEVGACSAPHEFC 566
            |||||.|||.|.||||.:.|.. ..|....:|||:.||...||.|.|
  Rat   481 RKYITEFLDTGYGECLLNEPQS-RTYPLPSQLPGLLYNVNKQCELIF------------------ 526

  Fly   567 STLWCKVNGECVTHMRPTAPGTLCGRNKWCQNGKCVRRE-ELAAVNGGWGDWSEWSECSRSCGGG 630
                              .||:.......|:.|.||.:| |..|::|.||.||.:..|||:||||
  Rat   527 ------------------GPGSQVCPYMHCKFGFCVPKEMEGPAIDGSWGSWSHFGACSRTCGGG 573

  Fly   631 VSTQQRECDNPVPANGGVFCIGERKRYKICRKRPCPAEEPSFRAQQCARFD----NVSYQGATYK 691
            :.|..|||:.|.|.|||.:|:|.|.::|.|...|||..:..||.:|||.||    |::....:.:
  Rat   574 IRTAIRECNRPEPKNGGRYCVGRRMKFKSCNTEPCPKHKRDFREEQCAYFDGKHFNINGLLPSVR 638

  Fly   692 WLPFFD---KNNPCKLFCSDVDDTIIANWGATVLDGTPCTLGTNNMCIDGICKKVGCDWIVDSEV 753
            |:|.:.   ..:.|||||....:|........|:|||||...||::|:.|:|::.|||.|::|:.
  Rat   639 WVPKYSGILMKDRCKLFCRVAGNTAYYQLRDRVIDGTPCGQDTNDICVQGLCRQAGCDHILNSKA 703

  Fly   754 QDDRCGVCGGSGDQCQPVRETYTDPFAAKDGAYVEIVTIPARARHILIRE-----LANSPHFLAI 813
            :.|:||:|||....|:.|..|    |......|..:|.|||.|..:.:|:     .:...::||:
  Rat   704 RKDKCGICGGDNSSCKTVAGT----FNTVHYGYNTVVRIPAGATSLDVRQHSFSGKSEDDNYLAL 764

  Fly   814 ATGDGGDRFYLNGDSLISM--------PGEFEIAGAESLYDRVDEQETITIPQPIQHSISLYAIV 870
            :...|  .|.||||.::||        ....|.:|::::.:|::..:.      |:..:.|..:.
  Rat   765 SNSRG--EFLLNGDFVVSMSKREVRVGSAMIEYSGSDNVVERLNCSDR------IEEELLLQVLS 821

  Fly   871 RGNESNAGIFYEFTLP------------------------------------------------- 886
            .|...|..:.|.|.:|
  Rat   822 VGKLYNPDVRYSFNIPIEDRSQQFYWNSHGPWQACSKPCQGERRRKLVCTRESDQLTVSDQRCDR 886

  Fly   887 ------------------------------------ALNVTAGRQFQ------------------ 897
                                                .|::...:..:
  Rat   887 LPQPGPVTEACGTDCDLRWHIASKSECSAQCGLGYRTLDIHCAKYSRVDGKTEKVDDSFCGSQPR 951

  Fly   898 ---------------WRLSNWTACSASCGGGVQHREPICQENGKALGDTLPCWTHAKNKRPARQS 947
                           ||.|.||.||.||.||.|.|..||......:.|...|         |:|.
  Rat   952 PSNQEKCSGECSTGGWRYSAWTECSKSCDGGTQRRRAICVNTRNDVLDDSKC---------AQQE 1007

  Fly   948 R----GCGDQPCPAHWWPGPWQFCPVTCRPVGFVAPPQRRRSVVCLDEHDVVVADAECGHLQKPA 1008
            :    .|.:..|| ||..|.|..|.|||      ....:.|.|.|....| .::|..|....||.
  Rat  1008 KVIVQRCNEFSCP-HWKTGEWSECLVTC------GKGHKHRQVWCQFGED-RLSDRMCDPEAKPE 1064

  Fly  1009 EMEPCESSLPIC 1020
            .|:.|:.  |.|
  Rat  1065 PMQMCQQ--PEC 1074

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AdamTS-B	NP_572247.2	Pep_M12B_propep	78..194	CDD:279848	36/136 (26%)
		ZnMc_ADAMTS_like	314..518	CDD:239801	93/210 (44%)
		Reprolysin	315..521	CDD:279729	94/212 (44%)
		ADAM_CR	<558..602	CDD:301627	4/43 (9%)
		TSP1	614..666	CDD:214559	26/51 (51%)
		ADAM_spacer1	773..886	CDD:283607	28/125 (22%)
		TSP1	901..956	CDD:214559	18/58 (31%)
Adamts9	NP_001101347.1	Pep_M12B_propep	72..207	CDD:279848	36/136 (26%)
		Reprolysin	294..500	CDD:279729	95/214 (44%)
		ZnMc_ADAMTS_like	294..497	CDD:239801	94/211 (45%)
		TSP1	557..609	CDD:214559	26/51 (51%)
		ADAM_spacer1	719..837	CDD:283607	29/129 (22%)
		TSP1	967..1020	CDD:214559	20/61 (33%)
		TSP1	1021..1074	CDD:214559	19/61 (31%)
		TSP1	1080..1132	CDD:214559
		TSP1	1152..1205	CDD:214559
		TSP1	1205..1262	CDD:214559
		TSP1	1294..1346	CDD:214559
		TSP1	1348..1402	CDD:214559
		TSP1	1407..>1430	CDD:214559
		TSP1	1466..1517	CDD:214559
		TSP1	1526..1575	CDD:214559
		TSP1	1577..>1602	CDD:214559
		GON	1700..1868	CDD:285848
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3538
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D125522at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100241
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.720