DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment AdamTS-B and Adamts14

DIOPT Version :9

Sequence 1:	NP_572247.2	Gene:	AdamTS-B / 31490	FlyBaseID:	FBgn0029791	Length:	1023	Species:	Drosophila melanogaster
Sequence 2:	NP_001376166.1	Gene:	Adamts14 / 309837	RGDID:	1308899	Length:	1203	Species:	Rattus norvegicus

Alignment Length:	1058	Identity:	309/1058 - (29%)
Similarity:	441/1058 - (41%)	Gaps:	175/1058 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 LGLLLHYWLVVVTQGGGVRP---LYGLHSDELVAGEGQLVVPRRVHPDGAFMTHQLEYAHELDHR 74
            |..||.::..:....|...|   |.|...|.:|      .||......|.|::|.:........|
  Rat     8 LHCLLPWYCALCAAAGSQTPDPRLSGKLHDYVV------TVPCSTDFQGRFLSHVVSAPAAASSR 66

  Fly    75 RHRQ--RRSLNSEHDTQAADLHLL---LPLANETLHLELMAHSYFLAPNLVVERHRRDLRT--RS 132
            .|.:  |..|:.|.:|.....|.|   :.:..:.|||.|..:...:||...|| .:.|.|.  |.
  Rat    67 SHLRVARSPLSLERETPRPRHHFLYFNVTVFGKLLHLRLQPNRRLVAPGAPVE-WQEDFRELFRQ 130

  Fly   133 PLTTRHLNCHFHGKVRGQPATNVAISTCAGLVGHIRTAGNEYFIEP-SKEHEPHPVNGHPHVVFQ 196
            ||   ...|.:.|.|.|.|...||||.|.||.|.|||..:::|||| .:..:.....|..|||::
  Rat   131 PL---QRECVYTGGVTGMPGAAVAISNCDGLAGLIRTDNSDFFIEPLERGQQEKEAGGRTHVVYR 192

  Fly   197 RSSVKPKHSLRKRNKRKRGGKSGSGAEVSNCGTREPRRRMETRLEWQARGKVKVQGGRQIRRHHH 261
            |.:|                                      :.||.
  Rat   193 REAV--------------------------------------QREWT------------------ 201

  Fly   262 HHHHHHHKHKYRHHQQKISRVPHTKFKYETQF-QTEPDHAEIPRRRRSISSPRHVETLIVADATM 325
            ..|...|...:     .:..:|:.......|. .||      .:||.:......:|.|:..|.::
  Rat   202 EPHGDLHNEAF-----GLGDLPNVLDLVGDQLGDTE------RKRRHAKPGSYSIEVLLAVDDSV 255

  Fly   326 SAFH--RDLNGYLLTIMNMVSALYKDPSIGNSIEIVVVRIIQLDEEESQLQLNLTQNAQKNLDRF 388
            ..||  .....|:||:||:|..:|.|.|:|..:.|.:||:|.:...:| |.|....|..::|::.
  Rat   256 VRFHGREHTQNYVLTLMNIVDEIYHDESLGAHVNIALVRLIMVGYRQS-LSLIERGNPARSLEQV 319

  Fly   389 CSWQHKLNKGSEKDPHHHDVAILITRKNICANNCMTLGLANVGGMCKPKQSCSVNEDNGIMLSHT 453
            |.|.|...:.......|||..|.:||:|...:     |.|.|.|||.|.:||::|.::|...:..
  Rat   320 CRWAHSQQRQDPSHTEHHDHVIFLTRQNFGPS-----GYAPVTGMCHPLRSCALNHEDGFSSAFV 379

  Fly   454 ITHELGHNFGMFHDTAKIGCHPRVGPIVHIMTPTFGADTLQVCWSNCSRKYITHFLDQGLGEC-L 517
            :.||.||..||.||....||..... :..:|.|...|...:..||.||:..::.:|..  ..| |
  Rat   380 VAHETGHVLGMEHDGQGNGCDDETS-LGSVMAPLVQAAFHRFHWSRCSKLELSRYLPS--YNCLL 441

  Fly   518 DDP-----PTPLDEYNYTGELPGMRYNARGQCRLQFNLTTDSEVGACSAPHEF--CSTLWCKVNG 575
            |||     |.|       .||||:.|:...|||..|.    :....|.|...|  |..|||....
  Rat   442 DDPFERTWPQP-------PELPGIDYSMDEQCRFDFG----TGYHTCLAFRTFEPCKQLWCSHPD 495

  Fly   576 E---CVTHMRPTAPGTLCGRNKWCQNGKCVRR--EELAAVNGGWGDWSEWSECSRSCGGGVSTQQ 635
            .   |.|...|...||.|...|||..|.||.:  |:....:|||..|:.:..|||||||||.::.
  Rat   496 NPYFCKTKKGPPLDGTECAPGKWCFKGHCVWKSPEQTYGQDGGWSSWTNFGSCSRSCGGGVRSRS 560

  Fly   636 RECDNPVPANGGVFCIGERKRYKICRKRPCPAEEPSFRAQQCARFDN-VSYQGATYKWLPF--FD 697
            |.||||.||.||..|.|....|:||....||.....|||||||:.:: .::|.|.:.|||:  ..
  Rat   561 RSCDNPPPAYGGRLCSGPMFEYQICNSEDCPGPFEDFRAQQCAKRNSYYTHQDAKHSWLPYEPDS 625

  Fly   698 KNNPCKLFCSDVDDTIIANWGATVLDGTPCTL-GTNNMCIDGICKKVGCDWIVDSEVQDDRCGVC 761
            :...|:|.|...|...:......|.|||.|:. ...::|..|.|...|||..|.|...||:||||
  Rat   626 EAQKCELICQSADTGDVVFMNQVVHDGTRCSYRDPYSVCARGECVPFGCDKEVGSMKTDDKCGVC 690

  Fly   762 GGSGDQCQPVRETYTDPFAAKDGAYVEIVTIPARARHILIRELANSPHFLAI---ATGDGGDRFY 823
            ||....|:.|:.|...  |:|..|.::.|.|||.||||.|..|..:|..:|:   .||.    |.
  Rat   691 GGDNSHCRTVKGTLGK--ASKQAAALKQVQIPAGARHIQIELLEKAPRRIAVKNQVTGS----FI 749

  Fly   824 LNGDSLISMPGEFEIAGAESLYDRVDEQETITIPQPIQHSISLYAI------VRGNESNAGIFYE 882
            ||.....:....|...|.|..:...|.::::....|:..:|::..:      .||:.:...:.:|
  Rat   750 LNPKGKEASSRTFTALGLEWEHAAEDTKDSLKTNGPLPEAIAVLVLPPAEGKPRGSLAYKYVIHE 814

  Fly   883 FTLPAL---NVTAGR--QFQWRLSNWTACSASCGGGVQHREPICQEN------GKALGDTLPCWT 936
            ..||.:   ||....  .::|.|.:|:.||.:||||:|..:..|:..      .:.|.|
  Rat   815 DLLPLIGSNNVLLEEMDSYEWALKSWSPCSKACGGGIQFTKYGCRHRRDHHMVQRHLCD------ 873

  Fly   937 HAKNKRPARQSRGCGDQPCPAHWW-PGPWQFCPVTCRPVGFVAPPQRRRSVVCL-----DEHDVV 995
              ..|||....|.|...|||...| ...|..|..:|..:|.     :.|.|.||     ..|..:
  Rat   874 --HKKRPKAIRRRCNQHPCPQPTWVTEEWGACSRSCGKLGL-----QTRGVQCLLPLSNGTHKAM 931

  Fly   996 VADAECGHLQKPAEMEPC 1013
            .|.|..|:  :|....||
  Rat   932 PAKACLGN--RPEAKRPC 947

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AdamTS-B	NP_572247.2	Pep_M12B_propep	78..194	CDD:279848	41/123 (33%)
		ZnMc_ADAMTS_like	314..518	CDD:239801	64/206 (31%)
		Reprolysin	315..521	CDD:279729	68/213 (32%)
		ADAM_CR	<558..602	CDD:301627	17/48 (35%)
		TSP1	614..666	CDD:214559	25/51 (49%)
		ADAM_spacer1	773..886	CDD:283607	30/121 (25%)
		TSP1	901..956	CDD:214559	17/60 (28%)
Adamts14	NP_001376166.1	Pep_M12B_propep	68..191	CDD:396235	43/126 (34%)
		ZnMc_ADAMTS_like	243..441	CDD:239801	64/206 (31%)
		ADAM_CR_2	456..525	CDD:407643	24/72 (33%)
		TSP1	539..591	CDD:214559	25/51 (49%)
		ADAM_spacer1	698..813	CDD:368694	30/120 (25%)
		TSP1_ADAMTS	835..890	CDD:408800	18/62 (29%)
		TSP1_ADAMTS	895..952	CDD:408800	16/60 (27%)
		TSP1_ADAMTS	956..1005	CDD:408800
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910