DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment AdamTS-B and Adamts8

DIOPT Version :9

Sequence 1:	NP_572247.2	Gene:	AdamTS-B / 31490	FlyBaseID:	FBgn0029791	Length:	1023	Species:	Drosophila melanogaster
Sequence 2:	XP_003750503.1	Gene:	Adamts8 / 300475	RGDID:	1308511	Length:	905	Species:	Rattus norvegicus

Alignment Length:	1024	Identity:	324/1024 - (31%)
Similarity:	471/1024 - (45%)	Gaps:	206/1024 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 SRWLGLLLHYWLVVVTQGGGVRPLYGLHSDELVAG----------EGQLVVPRRVHPDGAFMTHQ 64
            :||..|||              .|..|....||.|          ..:||||.|:
  Rat     8 TRWPPLLL--------------LLLQLPPPPLVCGAPARPGTRTQASELVVPTRL---------- 48

  Fly    65 LEYAHELDHRRHRQRRSLNSEHDTQAADLHLLLPLANETLHLELMAHSYFLAPNLVVER------ 123
                                  .:.|::|...|....::..|.|...:.||||...:||
  Rat    49 ----------------------PSSASELAFHLSAFGQSFVLRLAPDASFLAPEFKIERLGGSSA 91

  Fly   124 ---HRRDLRTRSPLTTRHLNCHFHGKVRGQPATNVAISTCAGLVGHIRTAGNEYFIEPSKEHEPH 185
               ....||          .|.|.|.|.|:..:..|:|.|.||.|....||.|:.|:|....:
  Rat    92 AAGGEPGLR----------GCFFSGTVNGERESLAAMSLCGGLSGSFLLAGEEFTIQPQGAGD-- 144

  Fly   186 PVNGHPHVVFQRSSVKPKHSLRKRNKRKRGGKSG-SGAEVSNCGTREPRRRMETRLEWQARGKVK 249
                         |:...|.|::....:|....| :.|||.         .:...|||:    |:
  Rat   145 -------------SLDQPHRLQRWGPGQRREDPGLAAAEVF---------PLPQGLEWE----VE 183

  Fly   250 VQGGRQIRRHHHHHHHHHHKHKYRHHQQKISRVPHTKFKYETQFQTE--PDHAEIPRRRRSISSP 312
            :..|:..||..:.......|...|.               ||:...|  |......|.:|.:|..
  Rat   184 MGDGQGQRRRDNEEDRERDKEGLRK---------------ETEDSREVTPPFGSKTRSKRFVSEA 233

  Fly   313 RHVETLIVADATMSAFH-RDLNGYLLTIMNMVSALYKDPSIGNSIEIVVVRIIQLDEEESQLQLN 376
            |.||.|:||||:|:||: .||..::||:|:|.:.:||.|||.|||.:|||:::.::||....:
  Rat   234 RFVEILLVADASMAAFYGTDLQNHILTVMSMAARIYKHPSIRNSINLVVVKVLIVEEEGWGPE-- 296

  Fly   377 LTQNAQKNLDRFCSWQHKLNKGSEKDPHHHDVAILITRKNIC--ANNCMTLGLANVGGMCKPKQS 439
            ::.|....|..|||||.:.||.|::.|.|:|.|||.||:|.|  ...|.|||:|:||.:|.|.:|
  Rat   297 VSDNGGLTLRNFCSWQRRFNKPSDRHPEHYDTAILFTRQNFCRKGEQCDTLGMADVGTICDPNKS 361

  Fly   440 CSVNEDNGIMLSHTITHELGHNFGMFHDTAKIGCHPRVGPI--VHIMTPTFGADTLQVCWSNCSR 502
            |||.:|.|:..::|:.|||||...|.||.:| .|....||:  .|:|.|.|......:.||.||.
  Rat   362 CSVIKDEGLQAAYTLAHELGHVLSMPHDDSK-PCVRLFGPMGKYHMMAPFFIHVNKTLPWSPCSA 425

  Fly   503 KYITHFLDQGLGECLDDPPT---PLDEYNYTGELPG--MRYNARGQCRLQFNLTTDSEVGAC--S 560
            .|:|..||.|.|:||.|.||   ||.    || |||  ..|....||:..|.    .:...|  :
  Rat   426 VYLTELLDDGHGDCLLDAPTSVLPLP----TG-LPGHSTLYELDQQCKQIFG----PDFRHCPNT 481

  Fly   561 APHEFCSTLWC--KVNGECVTHMRP----TAPGTLCGRNKWCQNGKCVRREEL----AAVNGGWG 615
            :..:.|..|||  :.:.|.:.|.:.    .|.||.||....|.:|.||.|||:    |.|:|.||
  Rat   482 SVEDICVQLWCRHRDSDEPICHTKNGSLLWADGTPCGPGHLCLDGSCVLREEVENPKAVVDGDWG 546

  Fly   616 DWSEWSECSRSCGGGVSTQQRECDNPVPANGGVFCIGERKRYKICRKRPCPAEEPSFRAQQCAR- 679
            .|..|.:|||:||||:....||||||.|.|||.||:|||.:|:.|:...||....|||.|||.:
  Rat   547 PWGPWGQCSRTCGGGIQFSNRECDNPAPQNGGRFCLGERVKYQSCKTEECPPNGKSFREQQCEKY 611

  Fly   680 --FDNVSYQGATYKWLPFFDKNNP---CKLFCSDVDDTIIANWGATVLDGTPCTLGTNNMCIDGI 739
              :::....|...:|:|.:...:|   |||||.....:....:...|:|||.|...|..:|:.|.
  Rat   612 NAYNHTDLDGNFLQWVPKYSGVSPRDRCKLFCRARGRSEFKVFETKVIDGTLCGPDTLAICVRGQ 676

  Fly   740 CKKVGCDWIVDSEVQDDRCGVCGGSGDQCQPVRETYTDPFAAKDGAYVEIVTIPARARHILIRE- 803
            |.|.|||.:|:|..:.|:||||||.|..|:.|..::| ||:.   .|.:||||||.|.:|.:::
  Rat   677 CVKAGCDHVVNSPKKLDKCGVCGGKGTACRKVSGSFT-PFSY---GYNDIVTIPAGATNIDVKQR 737

  Fly   804 ----LANSPHFLAIATGDGGDRFYLNGDSLIS-------MPGE-FEIAGAESLYDRVDEQETITI 856
                :.|...:||:.|.:|  ::.|||:..||       |.|. .:.:|:.:..:|:  |....:
  Rat   738 SHPGVQNDGSYLALKTANG--QYLLNGNLAISAIEQDILMKGTILKYSGSMATLERL--QSFQAL 798

  Fly   857 PQPIQHSISLYAIVRGNESNAGIFYEFTLP---ALNVTAGRQ------------FQWRLSNWTAC 906
            |:|:  ::.|.. |.|......:.|.|.:|   ..||.:.::            .:|.|.:|:.|
  Rat   799 PEPL--TVQLLT-VSGEVFPPKVKYTFFVPNDTDFNVQSSKERASTNIIQSLPYAEWVLGDWSEC 860

  Fly   907 SASCGGGVQHREPICQENGKALGDTLPCWTHAKNKRPARQSRGCGDQPC 955
            .::||||.|.|...|::......||.......::.:|      ||.|||
  Rat   861 PSTCGGGWQRRTVECRDPSGQASDTCDEALKPEDAKP------CGSQPC 903

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AdamTS-B	NP_572247.2	Pep_M12B_propep	78..194	CDD:279848	29/124 (23%)
		ZnMc_ADAMTS_like	314..518	CDD:239801	92/208 (44%)
		Reprolysin	315..521	CDD:279729	94/210 (45%)
		ADAM_CR	<558..602	CDD:301627	14/51 (27%)
		TSP1	614..666	CDD:214559	28/51 (55%)
		ADAM_spacer1	773..886	CDD:283607	34/125 (27%)
		TSP1	901..956	CDD:214559	17/55 (31%)
Adamts8	XP_003750503.1	Pep_M12B_propep	49..152	CDD:279848	31/127 (24%)
		Reprolysin	234..444	CDD:279729	95/212 (45%)
		ZnMc_ADAMTS_like	234..441	CDD:239801	93/209 (44%)
		ADAM_CR	463..529	CDD:301627	17/69 (25%)
		TSP1	545..597	CDD:214559	28/51 (55%)
		ADAM_spacer1	706..825	CDD:283607	35/129 (27%)
		TSP1	852..903	CDD:214559	17/56 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3538
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D125522at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100241
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.720