Protein Alignment AdamTS-B and Adamts15

DIOPT Version :10

• Sequence 1: NP_572247.2
• Gene: AdamTS-B / 31490
• FlyBaseID: FBgn0029791
• Length: 1023
• Species: Drosophila melanogaster
• Sequence 2: NP_001100280.1
• Gene: Adamts15 / 300474
• RGDID: 1309770
• Length: 950
• Species: Rattus norvegicus
• Alignment Length: 1050
• Identity: 333/1050 - (31%)
• Similarity: 468/1050 - (44%)
• Gaps: 207/1050 - (19%)

  Fly    45 EGQLVVPRRVHPDGAFMTHQLEYAHELDHRRHRQRRSLNSEHDTQAADLHLLLPLANETLHLELM 109
            |.::|||.|..||              .:.||..||......|   ..|...:....:..:|.|.
  Rat    22 EWEVVVPIRRDPD--------------INGRHYYRRGTEDSGD---QGLIFQITAFQQDFYLHLT 69

  Fly   110 AHSYFLAPNLVVERHRRDLR--TRSPLTTRHLNCHFHGKVRGQPATNVAISTCAGLVGHIRTAGN 172
            ..:.||||....|.....|:  |.|.|..|  .|.:.|.|..:|.:..|:|.|.||.|.....|.
  Rat    70 PDAQFLAPAFATEYLGVPLQRLTGSSLDLR--RCFYSGYVNAEPDSFAAVSLCGGLRGAFGYQGA 132

  Fly   173 EYFIEPSKEHEPHPVNGHPHVVFQRSSVKPKHSLRKRNKRKRGGKSG-SGAEVSNCGTR------ 230
            ||.|.|.      |....|..        .:||......::||...| ||...|.||..
  Rat   133 EYVISPL------PNTSAPEA--------QRHSQGAHLLQRRGAPVGPSGDPTSRCGVASGWNPA 183

  Fly   231 --------EPRRRMETRLEWQARGKVKVQGGRQIRRHHHHHHHHHHKHKYRHHQQKISRVPHTKF 287
                    :|||        ...|:                         .|::::..|.
  Rat   184 ILRALDPYKPRR--------TGVGE-------------------------SHNRRRSGRA----- 210

  Fly   288 KYETQFQTEPDHAEIPRRRRSISSPRHVETLIVADATMSAFH-RDLNGYLLTIMNMVSALYKDPS 351
                              :|.:|.||:||||:|||.:|..|| .||..||||::...:.||:.||
  Rat   211 ------------------KRFVSIPRYVETLVVADESMVKFHGADLEHYLLTLLATAARLYRHPS 257

  Fly   352 IGNSIEIVVVRIIQLDEEESQLQLNLTQNAQKNLDRFCSWQHKLNKGSEKDPHHHDVAILITRKN 416
            |.|.|.||||:::.|.:.::..:  :|.||...|..||:||.||||.|:|.|.:.|.|||.||::
  Rat   258 ILNPINIVVVKVLLLGDRDTGPK--VTGNAALTLRNFCAWQKKLNKVSDKHPEYWDTAILFTRQD 320

  Fly   417 IC-ANNCMTLGLANVGGMCKPKQSCSVNEDNGIMLSHTITHELGHNFGMFHDTAKIGCHPRVGPI 480
            :| |..|.|||:|:||.||.||:||||.||:|:..:.|..|||||.|.|.||..|: |....|.:
  Rat   321 LCGATTCDTLGMADVGTMCDPKRSCSVIEDDGLPSAFTTAHELGHVFNMPHDNVKV-CEEVFGKL 384

  Fly   481 --VHIMTPTFGADTLQV----CWSNCSRKYITHFLDQGLGEC-LDDPPTPLDEYNYTGELPGMRY 538
              .|:|:||.    :|:    .||.||...||.|||.|.|:| ||.|..|:   ....:|||..|
  Rat   385 RANHMMSPTL----IQIDRANPWSACSAAIITDFLDSGHGDCLLDQPSKPI---TLPEDLPGTSY 442

  Fly   539 NARGQCRLQFNLTTDSEVGACSAPH-EFCSTLWC--KVNGE--CVTHMRPTAPGTLCGRNKWCQN 598
            :...||.|.|.      ||:...|: ::|:.|||  |..|:  |.|...|.|.||.||..|:|..
  Rat   443 SLSQQCELAFG------VGSKPCPYMQYCTKLWCTGKAKGQMVCQTRHFPWADGTSCGEGKFCLK 501

  Fly   599 GKCVRRE--ELAAVNGGWGDWSEWSECSRSCGGGVSTQQRECDNPVPANGGVFCIGERKRYKICR 661
            |.||.|.  ....|:|.|..|..:..|||:|||||...:|:|.||.|||||.:|.|.|.:|:.|.
  Rat   502 GACVERHNPNKYRVDGSWAKWEPYGPCSRTCGGGVQLARRQCSNPTPANGGKYCEGVRVKYRSCN 566

  Fly   662 KRPCP--AEEPSFRAQQCARFDNVSYQGATYK------WLPFFDKNNP---CKLFCSDVDDTIIA 715
            ..|||  |...|||.:||..|:  .|..:|.:      |:|.:...:|   |||.|.........
  Rat   567 LEPCPSSASGKSFREEQCEAFN--GYNHSTNRLTLAVAWVPKYSGVSPRDKCKLICRANGTGYFY 629

  Fly   716 NWGATVLDGTPCTLGTNNMCIDGICKKVGCDWIVDSEVQDDRCGVCGGSGDQCQPVRETYTDPFA 780
            .....|:|||.||..:.::|:.|.|.|.|||..:.|:.:.|:||||||....|:.|...:|.|.
  Rat   630 VLAPKVVDGTLCTPDSTSVCVQGKCIKAGCDGNLGSKKKFDKCGVCGGDNKSCKRVTGLFTKPM- 693

  Fly   781 AKDGAYVEIVTIPARARHILIRE-----LANSPHFLAIATGDGGDRFYLNGDSLIS-MPGEFEIA 839
               ..|..:|.|||.|..|.||:     |....::||:....|  ::.|||..::| :..:..:.
  Rat   694 ---HGYNFVVAIPAGASSIDIRQRGYKGLIGDDNYLALKNSQG--KYLLNGHFVVSAVERDLVVK 753

  Fly   840 GAESLYDRVDEQ-ETITIPQPIQHSISLYAIVRGNESNAGIFYEFTL------------------ 885
            |:...|...... |::...:||...:::..:..|..:...:.|.|.|
  Rat   754 GSVLRYSGTGTAVESLQASRPILEPLTVEVLSVGKMTPPRVRYSFYLPKEPREDKSSRPKDPRGP 818

  Fly   886 PALN---VTAGRQFQ---------WRLSNWTACSASCGGGVQHREPICQENGKALGDTLPCWTHA 938
            |.|.   ::...|.:         |...||..||.|||.|:|.|...|:::....|.:.....|
  Rat   819 PVLRNSVLSLSNQVEQPDNRPPARWVAGNWGPCSVSCGSGLQKRAVDCRDSPGQQGISACDVDH- 882

  Fly   939 KNKRPARQSRGCGDQPCPAHWWPGPWQFCPVTCRPVGFVAPPQRRRSVVCLDEHDVVVADAECGH 1003
               ||. :.|.|| :|||. |..|.|..|..:|.. ||     :||.:.|:.....::|..:|..
  Rat   883 ---RPV-EKRACG-EPCPT-WELGNWSPCSKSCGR-GF-----KRRPLKCVGHGGRLLARDQCDL 935

  Fly  1004 LQKPAEMEPC 1013
            .:||.|::.|
  Rat   936 RRKPQELDFC 945

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
AdamTS-B	NP_572247.2	Pep_M12B_propep	47..195	CDD:460254	41/149 (28%)
		ZnMc_ADAMTS_like	314..518	CDD:239801	99/212 (47%)
		ADAMTS_CR_2	534..602	CDD:465496	27/72 (38%)
		TSP1	614..666	CDD:214559	25/51 (49%)
		ADAMTS_CR_3	672..768	CDD:437068	35/104 (34%)
		ADAMTS_spacer1	770..886	CDD:461796	29/140 (21%)
		TSP1	901..956	CDD:214559	19/54 (35%)
		TSP1_ADAMTS	959..1020	CDD:465950	15/54 (28%)
Adamts15	NP_001100280.1	Pep_M12B_propep	24..150	CDD:460254	41/158 (26%)
		ZnMc_ADAMTS_like	218..424	CDD:239801	100/212 (47%)
		ADAMTS_CR_2	438..505	CDD:465496	27/72 (38%)
		TSP1	519..571	CDD:214559	25/51 (49%)
		ADAMTS_CR_3	<616..682	CDD:437068	25/65 (38%)
		ADAMTS_spacer1	684..801	CDD:461796	28/122 (23%)
		TSP1_ADAMTS	843..894	CDD:465950	19/56 (34%)
		TSP1_ADAMTS	897..950	CDD:465950	15/54 (28%)