DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment AdamTS-B and Adamts12

DIOPT Version :9

Sequence 1:	NP_572247.2	Gene:	AdamTS-B / 31490	FlyBaseID:	FBgn0029791	Length:	1023	Species:	Drosophila melanogaster
Sequence 2:	NP_001099890.2	Gene:	Adamts12 / 294809	RGDID:	1307323	Length:	1599	Species:	Rattus norvegicus

Alignment Length:	1003	Identity:	358/1003 - (35%)
Similarity:	518/1003 - (51%)	Gaps:	132/1003 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    45 EGQLVVPRRVHPDGAFMTHQLEYAHELDHRRHRQRRSLNSEHDTQAADLHLLLPLANETLHLELM 109
            |..:|.|.:|...|.|:::.|.  |.:  ...|::|:.....|    .::..:....:.|...|.
  Rat    51 EYHIVSPVQVDASGHFLSYGLH--HPV--TGSRKKRAAGGSGD----QVYYRISHEEKNLFFNLT 107

  Fly   110 AHSYFLAPNLVVERHRRDLRTRSPLTTRHLNCHFHGKVRGQPAT----NVAISTCAGLVGHIRTA 170
            .:..||:...||||...:|.......:....||..|.|..|..|    ..|:|.|.||.|.....
  Rat   108 VNWEFLSNGYVVERRYGNLSHVKMAASSGQPCHLRGTVLQQGPTIRMGTAALSACQGLTGFFHLP 172

  Fly   171 GNEYFIEPSKEHEPHPVNGH-PHVVFQRSSVKPKHSLRKRNKRKRGGKSGSGAEVSNCGTREPRR 234
            ..::||||.|:| |....|: |||:::|.|.:...:     |....|...|   :.|...:|.:|
  Rat   173 HGDFFIEPVKKH-PLTEEGYQPHVIYRRQSYRVPET-----KEPTCGLKDS---LDNSVKQELQR 228

  Fly   235 RMETRLEWQARGKVKVQGGRQIRRHHHHHHHHHHKHKYRHHQQKISRVPHTKFKYETQFQTEPDH 299
            ....|..|.:|.
  Rat   229 EKWERKNWPSRS----------------------------------------------------- 240

  Fly   300 AEIPRRRRSISSPRHVETLIVADATMSAFH--RDLNGYLLTIMNMVSALYKDPSIGNSIEIVVVR 362
                ..|||||..|.||||:|||..|..:|  .::..|:|||||||:.|:.:|||||::.|||||
  Rat   241 ----LSRRSISKERWVETLVVADTKMVEYHGSENVESYILTIMNMVTGLFHNPSIGNAVHIVVVR 301

  Fly   363 IIQLDEEESQLQLNLTQNAQKNLDRFCSWQHKLNKGSEKDPHHHDVAILITRKNICA---NNCMT 424
            :|.|:|||..|:  :..:|:|.|..||.||..:|..|:.:|.|||||:|||||:|||   ..|.|
  Rat   302 LILLEEEEQGLK--IVHHAEKTLSSFCKWQKSINPKSDLNPVHHDVAVLITRKDICAGVNRPCET 364

  Fly   425 LGLANVGGMCKPKQSCSVNEDNGIMLSHTITHELGHNFGMFHDTAKIGCHPRVGPIVHIMTPTFG 489
            |||:.:.|||:|.:||::|||:|:.|:.||.|||||:||:.||..:..|.| ||...:||:....
  Rat   365 LGLSQLSGMCQPHRSCNINEDSGLPLAFTIAHELGHSFGIQHDGKENDCEP-VGRHPYIMSQQIQ 428

  Fly   490 ADTLQVCWSNCSRKYITHFLDQGLGECLDDPPTPLD-EYNYTGELPGMRYNARGQCRLQF--NLT 551
            .|...:.||.||::|||.|||:|.|.||||.|.... :.|...  ||:.|:...||:||:  |.|
  Rat   429 YDPTPLTWSKCSKEYITRFLDRGRGFCLDDVPRKKGLKSNVIA--PGVIYDVHHQCQLQYGPNAT 491

  Fly   552 TDSEVGACSAPHEFCSTLWCKVNGECVTHMRPTAPGTLCGRNKWCQNGKCV---RREELAAVNGG 613
                  .|......|.||||.|.|.|.:.:...|.||.||..|||..|||:   ::.|  ::.||
  Rat   492 ------FCQEVENVCQTLWCSVKGFCRSKLDAAADGTRCGEKKWCMAGKCITVGKKPE--SIPGG 548

  Fly   614 WGDWSEWSECSRSCGGGVSTQQRECDNPVPANGGVFCIGERKRYKICRKRPCPAEEPSFRAQQCA 678
            ||.||.||.|||:||.|..:.:|.|:||.|..||.:|.||||||::|...||.::.|:||..||:
  Rat   549 WGRWSPWSHCSRTCGAGAQSAERLCNNPEPKFGGKYCTGERKRYRLCNVHPCRSDTPTFRQMQCS 613

  Fly   679 RFDNVSYQGATYKWLPFFDKNNPCKLFCSDVDDTIIANWGATVLDGTPCTLGTN--NMCIDGICK 741
            .||.|.|:...|:|.|.|:..:||:|:|..:|:.........|:|||||..|.|  |:||:||||
  Rat   614 EFDTVPYKNQFYRWFPVFNPAHPCELYCRPIDEQFSERMLEAVIDGTPCFEGGNSRNVCINGICK 678

  Fly   742 KVGCDWIVDSEVQDDRCGVCGGSGDQCQPVRETYTDPFAAKDGA-YVEIVTIPARARHILIRELA 805
            :||||:.:||...:||||||.|.|..||.|::.    |..|:|: |::|..||..||.|.:.|:.
  Rat   679 RVGCDYEIDSNATEDRCGVCLGDGSACQTVKKV----FRQKEGSGYIDIGLIPKGARDIRVMEIK 739

  Fly   806 NSPHFLAIATGDGGDRFYLNGDSLISMPGEFEIAGAESLYDRVDEQETITIPQPIQHSISLYAIV 870
            .:.:||||.:.| .:::||||..:|...|.:::||....|||..:.|.:..|.|...|:.|..:.
  Rat   740 AAGNFLAIRSED-PEKYYLNGGFIIQWNGNYKLAGTVFQYDRKGDLERLMAPGPTNESVWLQLLF 803

  Fly   871 RGNESNAGIFYEFTL--PAL-NVTAGRQFQWRLSNWTACSASCGGGVQHREPICQENGKALGDTL 932
            :  .:|.||.||:|:  ..| |......:.|:...||.||.:||.|::.:...|.:.|..:..|.
  Rat   804 Q--VTNPGIKYEYTVRKDGLDNDVEKLLYFWQFGRWTECSVTCGTGIRRQTAHCVKKGHGIVKTT 866

  Fly   933 PCWTHAKNKRPARQSRGCGDQPCPAHWWPGPWQFCPVTCRPVGFVAPPQRRRSVVCL-----DEH 992
            .|   ....:|:.:.:.|.::.||..||.|.|:.|.:||.|.|     :::|:|:|:     ||.
  Rat   867 FC---NPETQPSVRQKKCYEKDCPPRWWAGEWEACSMTCGPYG-----EKKRTVLCIQTMGSDEQ 923

  Fly   993 DVVVADAECGHLQKPAEMEPCESSLPIC 1020
            .:...|  |.||.||..:..|...: :|
  Rat   924 ALPATD--CQHLLKPKTLVSCNRDI-LC 948

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AdamTS-B	NP_572247.2	Pep_M12B_propep	78..194	CDD:279848	33/120 (28%)
		ZnMc_ADAMTS_like	314..518	CDD:239801	104/208 (50%)
		Reprolysin	315..521	CDD:279729	107/210 (51%)
		ADAM_CR	<558..602	CDD:301627	19/43 (44%)
		TSP1	614..666	CDD:214559	28/51 (55%)
		ADAM_spacer1	773..886	CDD:283607	38/115 (33%)
		TSP1	901..956	CDD:214559	13/54 (24%)
Adamts12	NP_001099890.2	Pep_M12B_propep	80..196	CDD:279848	33/120 (28%)
		Reprolysin	250..460	CDD:279729	108/212 (51%)
		ZnMc_ADAMTS_like	250..457	CDD:239801	105/209 (50%)
		ADAM_CR	519..680	CDD:301627	76/162 (47%)
		TSP1	549..600	CDD:214559	27/50 (54%)
		ADAM_spacer1	706..816	CDD:283607	39/116 (34%)
		TSP1	832..887	CDD:214559	14/57 (25%)
		TSP1	950..1001	CDD:214559
		PARM	1021..>1176	CDD:293666
		TSP1	1429..1477	CDD:214559
		TSP1	1479..1536	CDD:214559
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	216	1.000	Domainoid score	I2619
eggNOG	1	0.900	-	-		E1_KOG3538
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	633	1.000	Inparanoid score	I803
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D125522at2759
OrthoFinder	1	1.000	-	-		FOG0001196
OrthoInspector	1	1.000	-	-		otm44747
orthoMCL	1	0.900	-	-		OOG6_100241
Panther	1	1.100	-	-	O	PTHR13723
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X2816
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	12	11.830