DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment AdamTS-B and Adamts17

DIOPT Version :9

Sequence 1:	NP_572247.2	Gene:	AdamTS-B / 31490	FlyBaseID:	FBgn0029791	Length:	1023	Species:	Drosophila melanogaster
Sequence 2:	XP_218753.6	Gene:	Adamts17 / 293004	RGDID:	1308783	Length:	1122	Species:	Rattus norvegicus

Alignment Length:	1129	Identity:	326/1129 - (28%)
Similarity:	479/1129 - (42%)	Gaps:	274/1129 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 LGLLLHYWLVVVTQGGGVRPLYGLHSDELV---AGEGQLVVPRRVHPDGAFMTHQLEYAHELDHR 74
            |.|||..|              ||....:|   |.:.::|:|||:.||...: ..|..|..|
  Rat    12 LSLLLLVW--------------GLDPGTVVGDAAADVEVVLPRRLRPDDVHL-QLLPGAAGL--- 58

  Fly    75 RHRQ-RRSLNSEHDTQAAD----LHLLLPLANETLHLELMAHSYFLAPNLVVERHRRDLRTRSPL 134
              || ||...|..|.:|..    |.|.||.....|:|:|.....||:|...||......|:..|.
  Rat    59 --RQWRRPRASPGDPRAGPGERALLLHLPAFGRDLYLQLRRDLRFLSPGFEVEEAGVSGRSGHPA 121

  Fly   135 TTRHLNCHFHGKVRGQPATNVAISTC---AGLVGHIRTAGNEYFIEPSKEHEPHPVNGHPHVVFQ 196
            ..    |.:.|:|.|.|.:.|::|.|   .||||.|:......||:|
  Rat   122 EL----CFYSGQVLGHPGSLVSLSACGAAGGLVGLIQLEQELVFIQP------------------ 164

  Fly   197 RSSVKPKHSLRKRNKRKRGGKSGSGAEVSNCGTREPRRRMETRLEWQARG--KVKVQGGRQIRRH 259
                                       ::|.|....||....|.:|.:..  ..||:|.||
  Rat   165 ---------------------------LNNSGGPFSRREHLIRRKWSSTSGLATKVEGPRQ---- 198

  Fly   260 HHHHHHHHHKHKYRHHQQKISRVPHTKFKYETQFQTEPDHAEIPRRRRS---ISSPRHVETLIVA 321
                           |.:.::.....|.|....:          |.||:   :::...||||:||
  Rat   199 ---------------HCKVVTEEKPRKGKLSWDW----------RERRNAIRLTNEHTVETLVVA 238

  Fly   322 DATMSAFH--RDLNGYLLTIMNMVSALYKDPSIGNSIEIVVVRIIQLDEEESQLQLNLTQNAQKN 384
            ||.|..:|  .....::||:||||..:::..|:|..|.|.|.:::.|.:..::|.:.  .:.:::
  Rat   239 DADMVQYHGAEAAQRFILTVMNMVYNMFQHQSLGIKINIQVTKLVLLRQRPAKLSIG--HHGERS 301

  Fly   385 LDRFCSWQHK---------LNK--GSEKDPHHHDVAILITRKNICANN---CMTLGLANVGGMCK 435
            |:.||.||::         .|:  |.:.|....|.|:.:||.:.|.:.   |.|:|:|.:||:|.
  Rat   302 LESFCHWQNEEYGGARYLGNNQVPGGKDDTPPVDAAVFVTRTDFCVHKDEPCDTVGIAYLGGVCS 366

  Fly   436 PKQSCSVNEDNGIMLSHTITHELGHNFGMFHDTAKIGCHPRVGPIVHIMTPTF--GADTLQVCWS 498
            .|:.|.:.||||:.|:.||.||||||.||.||.....|..|    .|||:..:  |.:...:.||
  Rat   367 AKRKCVLAEDNGLNLAFTIAHELGHNLGMNHDDDHSSCAGR----SHIMSGEWVKGRNPSDLSWS 427

  Fly   499 NCSRKYITHFLDQGLGECL--DDPPTPLDEYNYTGELPGMRYNARGQCRLQFNLTTDSEVGAC-S 560
            :|||..:.:||...:..||  .||.:. .......:||||.|:|..||::.|.    :....| :
  Rat   428 SCSRDDLENFLKSKVSTCLLITDPRSQ-HALRLPHKLPGMHYSANEQCQILFG----TNATFCKN 487

  Fly   561 APHEFCSTLWCKVNGE--CVTHMRPTAPGTLCGRNKWCQNGKCVRREELAA-VNGGWGDWSEWSE 622
            ..|..|:.|||.|.|:  |.|.:.|...||.||.:|||:.|:||.:..:.. |:|.|..||.||.
  Rat   488 MEHLMCAGLWCLVEGDTSCKTKLDPPLDGTECGADKWCRAGECVSKTPIPEHVDGDWSPWSAWSM 552

  Fly   623 CSRSCGGGVSTQQRECDNPVPANGGVFCIGERKRYKICRKRPCPAEEPSFRAQQCARFDNVSYQG 687
            |||:||.|...:||:||||.|..||..|.|....:..|...|||...||||.|||...|.:|.:.
  Rat   553 CSRTCGTGARFRQRKCDNPPPGPGGTHCQGASVEHAACENLPCPKGVPSFRDQQCQAHDRLSSKK 617

  Fly   688 ATYKWLPFFDKNNPCKLFCSDV---DDTIIANWGATVLDGTPCTLGTNNMCIDGICKKVGCDWIV 749
            .........| :.||:|:||.:   ...::|:   .|||||||.....::|:.|.|:|:|||.|:
  Rat   618 RGLLTAMVVD-DKPCELYCSPLGKESPLLVAD---RVLDGTPCGPYETDLCVYGRCQKIGCDGII 678

  Fly   750 DSEVQDDRCGVCGGSGDQCQPVRETYTDPFAAKDGAYVEIVTIPARARHILIRELANSPHFLAIA 814
            .|..::||||||.|.|..|:.|:..::.   ::...|:|.|.|||.||.|.:.|...:..|||:.
  Rat   679 GSAAKEDRCGVCSGDGKTCRVVKGDFSH---SRGTGYIEAVVIPAGARRIRVVEDKPAHSFLALK 740

  Fly   815 TGDGGDRFYLNGDSLISMPGEFEIAGA------ESLYDRVDEQETITIPQPIQHSISLYAIVRGN 873
              |...| .:|.|..|.:||||:|||.      ..|:::...:...|:|..:.       ::..:
  Rat   741 --DSSKR-SINSDWKIELPGEFQIAGTIVRYVRRGLWEKFSAKGPTTVPLHLM-------VLLFH 795

  Fly   874 ESNAGIFYEFTLPALNVTAGRQ---------FQWRLSNWTACSASCGGGVQHREPICQENGKALG 929
            :.|.||.||:|:|....|..:.         |.|..|.|..||..||||.:.
  Rat   796 DQNYGIHYEYTIPVNQSTENQSEPAKPQDALFLWTHSGWEGCSVQCGGGERR------------- 847

  Fly   930 DTLPCWTHAKNK--------------RPARQSRGCGDQPCPAHWWPGPWQFCPVTC--------- 971
             |:...|...||              ||..|.|.|...||.:.|..|.|..|..||
  Rat   848 -TIVSCTRIVNKTTTLVNDSDCPQASRPEPQVRRCNSHPCQSRWVAGQWSPCSATCEKGIQHREV 911

  Fly   972 --------------RPVGFVAPPQ--------------------------------RRRSVVCLD 990
                          ||: :.:.|:                                |:|:|.|.:
  Rat   912 TCVYQLQNGTHVTTRPI-YCSEPRPTPVQSCEGQDCLSIWEASEWSECSANCGKGIRKRTVTCTN 975

  Fly   991 EHDVVVADAECGHLQKPAEMEPCE 1014
                  :..:|....:|...|.||
  Rat   976 ------SQGKCDAATRPKAEEACE 993

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AdamTS-B	NP_572247.2	Pep_M12B_propep	78..194	CDD:279848	36/123 (29%)
		ZnMc_ADAMTS_like	314..518	CDD:239801	77/223 (35%)
		Reprolysin	315..521	CDD:279729	78/225 (35%)
		ADAM_CR	<558..602	CDD:301627	19/46 (41%)
		TSP1	614..666	CDD:214559	24/51 (47%)
		ADAM_spacer1	773..886	CDD:283607	34/118 (29%)
		TSP1	901..956	CDD:214559	18/68 (26%)
Adamts17	XP_218753.6	Pep_M12B_propep	61..179	CDD:279848	39/166 (23%)
		AANH_like	168..>244	CDD:294206	25/104 (24%)
		Reprolysin	230..447	CDD:279729	76/222 (34%)
		ZnMc_ADAMTS_like	230..447	CDD:239801	76/222 (34%)
		TSP1	544..596	CDD:214559	24/51 (47%)
		ADAM_spacer1	698..808	CDD:283607	35/122 (29%)
		TSP_1	893..946	CDD:278517	8/53 (15%)
		TSP1	950..>981	CDD:214559	4/36 (11%)
		TSP1	1001..1053	CDD:214559
		PLAC	1080..1106	CDD:285849
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	69	1.000	Domainoid score	I9371
eggNOG	1	0.900	-	-		E1_KOG3538
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D125522at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR13723
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.920