DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment AdamTS-B and Wfikkn2

DIOPT Version :9

Sequence 1:	NP_572247.2	Gene:	AdamTS-B / 31490	FlyBaseID:	FBgn0029791	Length:	1023	Species:	Drosophila melanogaster
Sequence 2:	XP_006533560.1	Gene:	Wfikkn2 / 278507	MGIID:	2669209	Length:	585	Species:	Mus musculus

Alignment Length:	449	Identity:	88/449 - (19%)
Similarity:	132/449 - (29%)	Gaps:	159/449 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   533 LPGMRYNARGQCRLQFNLTTDSEVGACSAPHEFCSTLW----------CKVNGECVTHMRPTAPG 587
            ||.:||:..|.|                 |::....||          |:.:.||.|:.:
Mouse    44 LPPIRYSHAGIC-----------------PNDMNPNLWVDAQSTCKRECETDQECETYEK----- 86

  Fly   588 TLCGRNKWCQNGKCV--RREELAAVNGGWGDWSEWSECSRSCGGGVSTQQ-RECD----NPVPAN 645
              |..|. |....||  |..::....|..|...|     .:|...:..|| .|||    .||
Mouse    87 --CCPNV-CGTKSCVAARYMDVKGKKGPVGMPKE-----ATCDHFMCLQQGSECDIWDGQPV--- 140

  Fly   646 GGVFCIGERKRYKICRKRPCPAEEPSFRAQQCARFDNVSYQGATYKWLPFFDKNNPCKLFCSDVD 710
                          |:.:....:||||   .||.      .|.||        .|.|
Mouse   141 --------------CKCKDRCEKEPSF---TCAS------DGLTY--------YNRC-------- 166

  Fly   711 DTIIANWGATVLDGTPCTLGTNNMCIDGICKKVGCDWIVDSEVQDDRCGVCGGSGDQCQPVRETY 775
                      .:|...|:.|   :.:..:..:....|                 .:...|..||.
Mouse   167 ----------FMDAEACSKG---ITLSVVTCRYHFTW-----------------PNTSPPPPETT 201

  Fly   776 TDPFAAKDGAYVEIVTIPARARHILIRELANSPHFLAIATGDGGDRFYLNGDSLISMPGEFEIAG 840
            ..|..|........:..||         |.|.|...::..|:... |..:   ::..|.. |:..
Mouse   202 VHPTTASPETLGLDMAAPA---------LLNHPVHQSVTVGETVS-FLCD---VVGRPRP-ELTW 252

  Fly   841 AESLYDRVDEQETITIPQPIQ-----HSISLYAIVRGNESNAGIFYEFTLPALNVTAGRQFQWRL 900
            .:.|.||   :..:..|..::     .:|:...|......:|||   :|..|.||....:..:.|
Mouse   253 EKQLEDR---ENVVMRPNHVRGNVVVTNIAQLVIYNVQPQDAGI---YTCTARNVAGVLRADFPL 311

  Fly   901 SNWTACSASCGGGVQHREPICQENGKALGDTLPCWTHAKNKRPARQSRGCGDQPCPAHW 959
            |       ...||..........||.|...| .|.     |.|  .|..||::....|:
Mouse   312 S-------VVRGGQARATSESSLNGTAFPAT-ECL-----KPP--DSEDCGEEQTRWHF 355

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AdamTS-B	NP_572247.2	Pep_M12B_propep	78..194	CDD:279848
		ZnMc_ADAMTS_like	314..518	CDD:239801
		Reprolysin	315..521	CDD:279729
		ADAM_CR	<558..602	CDD:301627	10/53 (19%)
		TSP1	614..666	CDD:214559	11/56 (20%)
		ADAM_spacer1	773..886	CDD:283607	23/117 (20%)
		TSP1	901..956	CDD:214559	13/54 (24%)
Wfikkn2	XP_006533560.1	WAP	51..100	CDD:365870	14/73 (19%)
		KAZAL_FS	147..183	CDD:238052	14/73 (19%)
		Ig_3	233..313	CDD:143242	19/97 (20%)
		KU	337..388	CDD:238057	7/26 (27%)
		Kunitz_BPTI	394..445	CDD:333766
		NTR_WFIKKN	464..572	CDD:239630
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3538
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900