DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment AdamTS-B and Adamts16

DIOPT Version :9

Sequence 1:	NP_572247.2	Gene:	AdamTS-B / 31490	FlyBaseID:	FBgn0029791	Length:	1023	Species:	Drosophila melanogaster
Sequence 2:	NP_742050.2	Gene:	Adamts16 / 271127	MGIID:	2429637	Length:	1222	Species:	Mus musculus

Alignment Length:	1073	Identity:	349/1073 - (32%)
Similarity:	499/1073 - (46%)	Gaps:	167/1073 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 PLYGLHSDELVAGEGQLVVPRRVHPDGAFMTHQLEYAHELDHRRHRQRRSLNSEHDTQAAD--LH 94
            |..|  |..|..||..||....|...|.:::|.:     :.::|.|:||::     ||...  ||
Mouse    44 PFSG--SSWLETGEYDLVSAYEVDHRGDYVSHDI-----MHYQRRRRRRAV-----TQPGGDALH 96

  Fly    95 LLLPLANETLHLELMAHSYFLAPNLVVERHRRDLRTRSPLTTRHLNCHFHGKVRGQPATNVAIST 159
            |.|......|||:|.|.|..:||..:|:...:.......:.....||.:.|.:|.|..::||:||
Mouse    97 LRLKGPRHDLHLDLKAASNLMAPGFMVQTLGKGGTKSVQMFPPEENCFYQGSLRSQGNSSVALST 161

  Fly   160 CAGLVGHIRTAGNEYFIEPSKEHEPHPVNGHPHVVFQRSSV--KPKHSLRKRNKRKRGGKSGSGA 222
            |.||:|.|||...:||::|...|....:|        ||:.  .|.|.|.||:..::
Mouse   162 CQGLLGMIRTKDTDYFLKPLPPHLTSKLN--------RSAQGDSPSHVLYKRSTERQ-------- 210

  Fly   223 EVSNCGTREPRRRMETRLEWQARGKVKVQGGRQIRRHHHHHHHHH----HKHKYRHHQQKISRVP 283
                 ..||....|.||             .|.:.|.|.||.:.|    .|..:...::|....|
Mouse   211 -----APRENEVLMITR-------------KRDLARPHLHHDNFHLGPSQKQHFCGRRKKYMPQP 257

  Fly   284 HTKFKYETQFQTEPDHAEIPRRRRSI-----SSPRHVETLIVADATM--SAFHRDLNGYLLTIMN 341
            .....|....:.:|.    .|.:||:     :...:||||:|.|..|  |..|.::..|:|||:|
Mouse   258 PNDDLYILPDEYKPS----SRHKRSLLKSHRNEELNVETLVVVDRKMMQSHGHENITTYVLTILN 318

  Fly   342 MVSALYKDPSIGNSIEIVVVRIIQLDEEESQLQLNLTQNAQKNLDRFCSWQHKLNKGSEKDPHHH 406
            |||||:||.:||.:|.||:|.:|.|::|  |..|.::.:|...|..||.||..|   ..||...|
Mouse   319 MVSALFKDGTIGGNINIVIVGLILLEDE--QPGLAISHHADHTLTSFCQWQSGL---MGKDGTRH 378

  Fly   407 DVAILITRKNICA---NNCMTLGLANVGGMCKPKQSCSVNEDNGIMLSHTITHELGHNFGMFHDT 468
            |.|||:|..:||:   ..|.|||.|.:.|||...:||:||||:|:.|:.||.||.||||||.||.
Mouse   379 DHAILLTGLDICSWKNEPCDTLGFAPISGMCSKYRSCTVNEDSGLGLAFTIAHESGHNFGMVHDG 443

  Fly   469 AKIGCHPRVGPIVHIMTPTFGADTLQVCWSNCSRKYITHFLDQGLGECLDDPPTPLDEYNYTGEL 533
            ....|....|   :||:||.........||:|||:|:..||......||.|.|.|:.||.|..:|
Mouse   444 EGNMCKKSEG---NIMSPTLAGRNGVFSWSSCSRQYLHKFLSTAQAICLADQPKPVKEYKYPEKL 505

  Fly   534 PGMRYNARGQCRLQFNLTTDSEVGACSAP--HEFCSTLWC-KVNGECVTHMRPTAPGTLCGRNKW 595
            ||..|:|..||:.||.    .:...|...  .:.|..||| ::..:|.|...|.|.|||||::.|
Mouse   506 PGQLYDANTQCKWQFG----EKAKLCMLDFRKDICKALWCHRIGRKCETKFMPAAEGTLCGQDMW 566

  Fly   596 CQNGKCVR--REELAAVNGGWGDWSEWSECSRSCGGGVSTQQRECDNPVPANGGVFCIGERKRYK 658
            |:.|:||:  .|.....:|.|.|||.||.|||:||||:|.:.|.|.||.|::||.||.|..:..|
Mouse   567 CRGGQCVKYGDEGPKPTHGHWSDWSPWSPCSRTCGGGISHRDRLCTNPRPSHGGKFCQGSTRTLK 631

  Fly   659 ICRKRPCPAEEPSFRAQQCARFDNVSYQGATYKWLPF--FDKNNPCKLFCSDVDDTIIANWGATV 721
            :|..:.||.:...|||.|||.:::..::|..|||.|:  .:..:.|||:|.........:....|
Mouse   632 LCNSQRCPLDSVDFRAAQCAEYNSKRFRGWLYKWKPYTQLEDQDLCKLYCIAEGFDFFFSLSNKV 696

  Fly   722 LDGTPCTLGTNNMCIDGICKKVGCDWIVDSEVQDDRCGVCGGSGDQCQPVRETYTDPFAAKDGAY 786
            .|||||:..:.|:||||:|::||||.::.|:..:|.||||.|:...|...|..|:...:...  |
Mouse   697 KDGTPCSEDSRNVCIDGMCERVGCDNVLGSDATEDSCGVCKGNNSDCVTHRGLYSKHHSTNQ--Y 759

  Fly   787 VEIVTIPARARHILIRELANSPHFLAIATGDGGDRFYLNGDSLISMPGEFEIAGAESLYDR-VDE 850
            ..:||||:.||.|.|.|...|..::::.  :...|:||||...:..||.::.:||...|.| ..|
Mouse   760 YHMVTIPSGARSIHIYETNISTSYISVR--NSLKRYYLNGHWSVDWPGRYKFSGATFNYKRSYKE 822

  Fly   851 QETITIPQPIQHSISLYAIVRGNESNAGIFYEFTLPA---------------------------- 887
            .|.:|.|.|...::.:..:.:|.  |.|:.:||:||.
Mouse   823 PENLTSPGPTNETLIVELLFQGR--NPGVAWEFSLPRSGAKKTPAAQPSYSWAIVRSECSVSCGG 885

  Fly   888 ------------LNVTAGRQF---------------------QWRLSNWTACSASCGGGVQHREP 919
                        |.|.....|                     .|.:.||:.||.:||||.|.|..
Mouse   886 GKMNSKAGCYRDLKVPVNASFCNPKTRPVTGLVPCKVSPCPSSWSVGNWSVCSRTCGGGTQSRPV 950

  Fly   920 ICQENGKALGDTLPCWTHAKNKRPARQSRGCGDQPCPAHWWPGPWQFCPVTCRPVGFVAPPQRRR 984
            .|........:::|.....:.:.|..|:  |..|.||..|..|||..|..||      ....|:|
Mouse   951 RCTRRAHYRDESIPASLCPQPEPPIHQA--CNSQSCPPAWSTGPWAECSRTC------GKGWRKR 1007

  Fly   985 SVVCLDEHDVVVA----DAECGHLQKPAEMEPC 1013
            :|.|...:....|    |..|....||...|.|
Mouse  1008 TVACKSTNPSARAQLLHDTACTSEPKPRTHEIC 1040

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AdamTS-B	NP_572247.2	Pep_M12B_propep	78..194	CDD:279848	38/117 (32%)
		ZnMc_ADAMTS_like	314..518	CDD:239801	92/208 (44%)
		Reprolysin	315..521	CDD:279729	94/210 (45%)
		ADAM_CR	<558..602	CDD:301627	17/46 (37%)
		TSP1	614..666	CDD:214559	26/51 (51%)
		ADAM_spacer1	773..886	CDD:283607	33/113 (29%)
		TSP1	901..956	CDD:214559	16/54 (30%)
Adamts16	NP_742050.2	Pep_M12B_propep	88..187	CDD:279848	35/98 (36%)
		Cysteine switch. /evidence=ECO:0000250	245..253		0/7 (0%)
		ZnMc_ADAMTS_like	288..489	CDD:239801	91/208 (44%)
		Reprolysin	290..493	CDD:279729	94/210 (45%)
		TSP1	587..639	CDD:214559	26/51 (51%)
		Spacer	745..871		36/131 (27%)
		ADAM_spacer1	745..856	CDD:283607	34/116 (29%)
		TSP1	927..985	CDD:214559	17/59 (29%)
		TSP1	988..>1017	CDD:214559	11/34 (32%)
		TSP1	1056..1113	CDD:214559
		TSP1	1126..1179	CDD:214559
		PLAC	1188..1218	CDD:285849
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3538
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D125522at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm42682
orthoMCL	1	0.900	-	-		OOG6_100241
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.720