DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment AdamTS-B and Adamts19

DIOPT Version :9

Sequence 1:	NP_572247.2	Gene:	AdamTS-B / 31490	FlyBaseID:	FBgn0029791	Length:	1023	Species:	Drosophila melanogaster
Sequence 2:	XP_006525982.1	Gene:	Adamts19 / 240322	MGIID:	2442875	Length:	1234	Species:	Mus musculus

Alignment Length:	1068	Identity:	304/1068 - (28%)
Similarity:	431/1068 - (40%)	Gaps:	255/1068 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    85 EHDTQAADLHLLLPLANETLHLELMAHSYFLAPNLVVERHRRDLRTRSPLTTR-----------H 138
            :.:..|.::.|.:|..:..|:|.|.....|||....||:..:.    .|..||           .
Mouse   160 QEEPSAEEVLLRIPALSRDLYLLLRRDGRFLAQRFAVEQWPKP----GPDPTRATADPGSSLLPD 220

  Fly   139 LNCHFHGKVRGQPATNVAISTC-AGLVGHIRTAGNEYFIEPSKEHEPHPVNGHPHVVFQRSSVKP 202
            .:|.:.|.|...|.:..:.||| .||:|.|:...:..||||.  ::...:.||||.::
Mouse   221 ASCFYTGTVLRHPGSLASFSTCGGGLMGFIQLNEDFLFIEPF--NDTMAIIGHPHRLY------- 276

  Fly   203 KHSLRKRNKRKRGGKSGSGAEVSNCGTREPRRRMETRLEWQARGKVKVQGGRQIRRHHHHHHHHH 267
                  |.||....|....:.|                                    |.||...
Mouse   277 ------RQKRSTEEKVTENSAV------------------------------------HRHHCGV 299

  Fly   268 HKHKYRHHQQKISRVPHTKFKYETQFQTEPDHAEIPRRRRSISSPRHVETLIVADATMSAFH--R 330
            ...|.|...:||:                 |:....|....:|...::||::|||..|.::|  .
Mouse   300 ISDKGRPRSKKIA-----------------DNRREKRYSYKLSQEYNIETVVVADPAMVSYHGAD 347

  Fly   331 DLNGYLLTIMNMVSALYKDPSIGNSIEIVVVRIIQLDEEESQLQLNLTQNAQKNLDRFCSWQHKL 395
            ....::|||:|||..|::..|:|..:.:.|:::|.|.|..:.|.:.  .:.:|.|:.||.|||:
Mouse   348 AARRFILTILNMVFNLFQHKSLGVQVNLRVLKLILLHETPADLYIG--HHGEKMLESFCKWQHE- 409

  Fly   396 NKGSEKDPHHH------------DVAILITRKNICANN---CMTLGLANVGGMCKPKQSCSVNED 445
            ..|...|.|..            |.|||||||:.|.:.   |.|:|:|.:.|||..|:.|.:.||
Mouse   410 EFGRRNDVHLEMSTSWGEDIAAVDAAILITRKDFCVHKDEPCDTVGIAYLNGMCSEKRKCIIAED 474

  Fly   446 NGIMLSHTITHELGHNFGMFHDTAKIGCHPRVGPIVHIMTPTF--GADTLQVCWSNCSRKYITHF 508
            ||:.|:.||.||:|||.|:.||..    ||.....:|||:..:  |.:...|.||.||::.:..|
Mouse   475 NGLNLAFTIAHEMGHNMGINHDND----HPSCADGLHIMSGEWIKGQNLGDVSWSRCSKEDLERF 535

  Fly   509 LDQGLGEC-LDDPPTPLDEYNYTGELPGMRYNARGQCRLQFNLTTDSEVGAC-SAPHEFCSTLWC 571
            |......| |...|..|.......:||||.|.|..||::.|.    .....| ...|..|:.|||
Mouse   536 LRSKASSCLLHTDPQSLSSVLVPSKLPGMAYTADEQCQILFG----PLASFCQEMQHVICTGLWC 596

  Fly   572 KVNG--ECVTHMRPTAPGTLCGRNKWCQNGKCVRR----EELAAVNGGWGDWSEWSECSRSCGGG 630
            ||.|  ||.|.:.|...||.|...|||:.|:|.||    |.||      |:||.||.|||||..|
Mouse   597 KVEGEAECRTKLDPPMDGTDCDPGKWCKAGECTRRTPAPEHLA------GEWSPWSSCSRSCSSG 655

  Fly   631 VSTQQRECDNPVPANGGVF--CIGERKRYKICRKRPCPAEEPSFRAQQCARFD-NVSYQGATYKW 692
            ||:::|:|    |..|...  |.|.||:|:||...||||..|.||..||..:. ..||.....:|
Mouse   656 VSSRERKC----PGLGSEARDCNGPRKQYRICENPPCPAGLPGFRDWQCQAYSVRTSYPKHALQW 716

  Fly   693 LPFFDKNNPCKLFCSDVDDTIIANWGATVLDGTPCTLGTNNMCIDGICKKVGCDWIVDSEVQDDR 757
            ...||:..||.||||.|...........|:|||.|.....::|.:|.|:|.|||.::.|..::|.
Mouse   717 QAVFDEEKPCALFCSPVGKEQPVLLSEKVMDGTSCGYQGLDICANGRCQKAGCDGLLGSLAREDH 781

  Fly   758 CGVCGGSGDQCQPVRETYTDPFAAKDGAYVEIVTIPARARHILIRELANSPHFLAIATGDGGDRF 822
            ||||.|:|..|:.::..:..   .:...|||::.|||.||.|.:.|...:..|||:.   ...:.
Mouse   782 CGVCNGNGKSCKVIKGDFNH---TRGAGYVEVLVIPAGARRIKVVEEKPAHSFLALR---DASKQ 840

  Fly   823 YLNGDSLISMPGEFEIAGAESLYDRVDEQETITIPQPIQHSISLYAIVRGNESNAGIFYEFTLPA 887
            .:|.|..|...|.|.:||....|.|....|.|:...|....:.|..:: ..:.|.|:.||:|:|:
Mouse   841 SINSDWKIEHSGAFSLAGTTVHYLRRGLWEKISAKGPTTTPLHLLVLL-FQDQNYGLHYEYTVPS 904

  Fly   888 -------------------------LNVTAG---------------------------------- 893
                                     .|.|.|
Mouse   905 DPLPDNQSSKEPGPLFMWTHAGWGDCNATCGGGERKTMVSCTKIMSKNISLVDNKKCKDLTKPEP 969

  Fly   894 ---------------------------------RQFQWRLSNWTACSASCGGGVQHREPICQ--- 922
                                             |..:|.::.||.||.:||.|||.|:..|.
Mouse   970 QIRKCNEQPCQTSPCGTVTTLRQTVCHQLYISVRFTRWMMTEWTTCSRTCGKGVQSRQVACTQQL 1034

  Fly   923 ENGKALGDTLPCWTH-AKNKRPARQSRGCGDQPCPAHWWPGPWQFCPVTCRPVGFVAPPQRRRSV 986
            ||    |..:..|.. ....:||...| |..|.|...|..|.|..|.|.|      ....|.|:|
Mouse  1035 EN----GTLIRAWERDCLGPKPATVQR-CEGQDCMTVWEAGVWSECSVKC------GKGVRHRTV 1088

  Fly   987 VCLDEHDVVVADAECGHLQKPAEMEPCE 1014
            .|.:..      .:|....:|.|.|.||
Mouse  1089 RCTNPR------KKCVLSTRPREAEDCE 1110

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AdamTS-B	NP_572247.2	Pep_M12B_propep	78..194	CDD:279848	33/120 (28%)
		ZnMc_ADAMTS_like	314..518	CDD:239801	78/223 (35%)
		Reprolysin	315..521	CDD:279729	79/225 (35%)
		ADAM_CR	<558..602	CDD:301627	20/46 (43%)
		TSP1	614..666	CDD:214559	25/53 (47%)
		ADAM_spacer1	773..886	CDD:283607	31/112 (28%)
		TSP1	901..956	CDD:214559	20/58 (34%)
Adamts19	XP_006525982.1	Pep_M12B_propep	161..276	CDD:366707	33/120 (28%)
		ZnMc_ADAMTS_like	328..545	CDD:239801	78/223 (35%)
		ADAM_CR_2	562..629	CDD:375321	28/70 (40%)
		ADAM_spacer1	793..903	CDD:368694	31/116 (27%)
		TSP1	1010..1063	CDD:214559	20/57 (35%)
		TSP1	1066..1111	CDD:214559	16/57 (28%)
		TSP1	1115..1170	CDD:214559
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3538
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D125522at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR13723
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.920