DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment AdamTS-B and Adamts12

DIOPT Version :9

Sequence 1:	NP_572247.2	Gene:	AdamTS-B / 31490	FlyBaseID:	FBgn0029791	Length:	1023	Species:	Drosophila melanogaster
Sequence 2:	NP_780710.2	Gene:	Adamts12 / 239337	MGIID:	2146046	Length:	1600	Species:	Mus musculus

Alignment Length:	1005	Identity:	359/1005 - (35%)
Similarity:	518/1005 - (51%)	Gaps:	136/1005 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    45 EGQLVVPRRVHPDGAFMTHQLEYAHELDHRRHRQRRSLNSEHDTQAADLHLLLPLANETLHLELM 109
            |..:|.|.:|...|    |.|.|.........|::|:.....|    .|:..:....:.|...|.
Mouse    51 EYHIVSPVQVDAGG----HVLSYGLHHPVTSSRKKRAAGGSGD----QLYYRISHEEKDLFFNLT 107

  Fly   110 AHSYFLAPNLVVERHRRDLRTRSPLTTRHLNCHFHGKVRGQPAT----NVAISTCAGLVGHIRTA 170
            .:..||:...|||:...:|.....:.:....||..|.|..|..|    ..|:|.|.||.|.....
Mouse   108 VNWEFLSNGYVVEKRYGNLSHVKMVASSGQPCHLRGTVLQQGTTVGIGTAALSACQGLTGFFHLP 172

  Fly   171 GNEYFIEPSKEHEPHPVNGHPHVVFQRSSVKPKHSLRKRNKRKRGGKSGSGAEVSNCGTREPRRR 235
            ..::||||.|:|.......:||||::|.|::...                        |:||...
Mouse   173 HGDFFIEPVKKHPLTEEGSYPHVVYRRQSIRAPE------------------------TKEPICG 213

  Fly   236 METRLEWQARGKVKVQGGRQIRRHHHHHHHHHHKHKYRHHQQKISRVPHTKFKYETQFQTEPDHA 300
            ::..|:    ..||                           |::.|   .|::.:|
Mouse   214 LKDSLD----NSVK---------------------------QELQR---EKWERKT--------- 235

  Fly   301 EIPRR---RRSISSPRHVETLIVADATMSAFH--RDLNGYLLTIMNMVSALYKDPSIGNSIEIVV 360
             :..|   |||||..|.||||:|||.....:|  .::..|:|||||||:.|:..|||||.:.|||
Mouse   236 -LRSRSLSRRSISKERWVETLVVADTKTVEYHGSENVESYILTIMNMVTGLFHSPSIGNLVHIVV 299

  Fly   361 VRIIQLDEEESQLQLNLTQNAQKNLDRFCSWQHKLNKGSEKDPHHHDVAILITRKNICA---NNC 422
            ||:|.|:|||..|:  :..:|:|.|..||.||..:|..|:.:|.|||||:|||||:|||   ..|
Mouse   300 VRLILLEEEEQGLK--IVHHAEKTLSSFCKWQKSINPKSDLNPVHHDVAVLITRKDICAGVNRPC 362

  Fly   423 MTLGLANVGGMCKPKQSCSVNEDNGIMLSHTITHELGHNFGMFHDTAKIGCHPRVGPIVHIMTPT 487
            .||||:.:.|||:|.:||::|||:|:.|:.||.|||||:||:.||..:..|.| ||...:||:..
Mouse   363 ETLGLSQLSGMCQPHRSCNINEDSGLPLAFTIAHELGHSFGIQHDGKENDCEP-VGRHPYIMSQQ 426

  Fly   488 FGADTLQVCWSNCSRKYITHFLDQGLGECLDDPPTPLD-EYNYTGELPGMRYNARGQCRLQF--N 549
            ...|...:.||.||::|||.|||:|.|.||||.|:... :.|...  ||:.|:...||:||:  |
Mouse   427 IQYDPTPLTWSKCSKEYITRFLDRGRGFCLDDIPSKKGLKSNVIA--PGVIYDVHHQCQLQYGPN 489

  Fly   550 LTTDSEVGACSAPHEFCSTLWCKVNGECVTHMRPTAPGTLCGRNKWCQNGKCV---RREELAAVN 611
            .|      .|......|.||||.|.|.|.:.:...|.||.||..|||..|||:   ::.|  ::.
Mouse   490 AT------FCQEVENVCQTLWCSVKGFCRSKLDAAADGTRCGEKKWCMAGKCITVGKKPE--SIP 546

  Fly   612 GGWGDWSEWSECSRSCGGGVSTQQRECDNPVPANGGVFCIGERKRYKICRKRPCPAEEPSFRAQQ 676
            ||||.||.||.|||:||.|..:.:|.|:||.|..||.:|.||||||::|...||.::.|:||..|
Mouse   547 GGWGRWSPWSHCSRTCGAGAQSAERLCNNPEPKFGGKYCTGERKRYRLCNVHPCRSDTPTFRQMQ 611

  Fly   677 CARFDNVSYQGATYKWLPFFDKNNPCKLFCSDVDDTIIANWGATVLDGTPCTLGTN--NMCIDGI 739
            |:.||.|.|:...|:|.|.|:..:||:|:|..:|:.........|:|||||..|.|  |:||:||
Mouse   612 CSEFDTVPYKNQFYRWFPVFNAAHPCELYCRPIDEQFSERMLEAVIDGTPCFEGGNSRNVCINGI 676

  Fly   740 CKKVGCDWIVDSEVQDDRCGVCGGSGDQCQPVRETYTDPFAAKDGA-YVEIVTIPARARHILIRE 803
            ||:||||:.:||...:||||||.|.|..||.|::.    |..|:|: ||:|..||..||.|.:.|
Mouse   677 CKRVGCDYEIDSNATEDRCGVCLGDGSACQTVKKL----FRQKEGSGYVDIGLIPKGARDIRVME 737

  Fly   804 LANSPHFLAIATGDGGDRFYLNGDSLISMPGEFEIAGAESLYDRVDEQETITIPQPIQHSISLYA 868
            :..:.:||||.:.| .:::||||..:|...|.:::||....|||..:.|.:..|.|...|:.|..
Mouse   738 IKAAGNFLAIRSED-PEKYYLNGGFIIQWNGNYKLAGTVFQYDRKGDLEKLIAPGPTNESVWLQL 801

  Fly   869 IVRGNESNAGIFYEFTL--PAL-NVTAGRQFQWRLSNWTACSASCGGGVQHREPICQENGKALGD 930
            :.:  .:|.||.||:|:  ..| |......:.|:...||.||.:||.|::.:...|.:.|..:..
Mouse   802 LFQ--VTNPGIKYEYTVRKDGLDNDVEKLLYFWQFGRWTECSVTCGTGIRRQAAHCVKKGHGIVK 864

  Fly   931 TLPCWTHAKNKRPARQSRGCGDQPCPAHWWPGPWQFCPVTCRPVGFVAPPQRRRSVVCL-----D 990
            |..|   ....:|:.:.:.|.::.||..||.|.|:.|..||.|.|     :::|:|:|:     |
Mouse   865 TTFC---NPETQPSVRQKKCHEKDCPPRWWAGEWEACSTTCGPYG-----EKKRTVLCIQTMGSD 921

  Fly   991 EHDVVVADAECGHLQKPAEMEPCESSLPIC 1020
            |..:...|  |.||.||..:..|...: :|
Mouse   922 EQALPATD--CQHLLKPKALVSCNRDI-LC 948

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AdamTS-B	NP_572247.2	Pep_M12B_propep	78..194	CDD:279848	31/119 (26%)
		ZnMc_ADAMTS_like	314..518	CDD:239801	103/208 (50%)
		Reprolysin	315..521	CDD:279729	106/210 (50%)
		ADAM_CR	<558..602	CDD:301627	19/43 (44%)
		TSP1	614..666	CDD:214559	28/51 (55%)
		ADAM_spacer1	773..886	CDD:283607	39/115 (34%)
		TSP1	901..956	CDD:214559	13/54 (24%)
Adamts12	NP_780710.2	Pep_M12B_propep	80..196	CDD:279848	31/119 (26%)
		Cysteine switch. /evidence=ECO:0000250	210..217		1/6 (17%)
		Reprolysin	250..460	CDD:279729	107/212 (50%)
		ZnMc_ADAMTS_like	250..457	CDD:239801	104/209 (50%)
		ADAM_CR	519..680	CDD:301627	76/162 (47%)
		TSP1	549..600	CDD:214559	27/50 (54%)
		Spacer 1	705..831		44/132 (33%)
		ADAM_spacer1	706..816	CDD:283607	40/116 (34%)
		TSP1	832..887	CDD:214559	14/57 (25%)
		TSP1	950..1001	CDD:214559
		Spacer 2	1001..1321
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1006..1140
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1158..1179
		TSP1	1430..1478	CDD:214559
		TSP1	1480..1537	CDD:214559
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	212	1.000	Domainoid score	I2766
eggNOG	1	0.900	-	-		E1_KOG3538
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	635	1.000	Inparanoid score	I835
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D125522at2759
OrthoFinder	1	1.000	-	-		FOG0001196
OrthoInspector	1	1.000	-	-		otm42682
orthoMCL	1	0.900	-	-		OOG6_100241
Panther	1	1.100	-	-	O	PTHR13723
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5231
SonicParanoid	1	1.000	-	-		X2816
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	12	11.860