DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment AdamTS-B and Adamts14

DIOPT Version :9

Sequence 1:	NP_572247.2	Gene:	AdamTS-B / 31490	FlyBaseID:	FBgn0029791	Length:	1023	Species:	Drosophila melanogaster
Sequence 2:	NP_001074596.1	Gene:	Adamts14 / 237360	MGIID:	2179942	Length:	1206	Species:	Mus musculus

Alignment Length:	1128	Identity:	314/1128 - (27%)
Similarity:	454/1128 - (40%)	Gaps:	241/1128 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 WLGLLLH----YWLVVVTQGGGVRP---LYGLHSDELVAGEGQLVVPRRVHPDGAFMTHQLEYAH 69
            ||..|||    ::..:....|...|   |.|...|.:|      .||......|.|::|.:....
Mouse     3 WLRALLHCLLPWYCALCAAAGSQTPDLRLSGKLHDYVV------TVPCSTDFQGRFLSHVVSAPA 61

  Fly    70 ELDHRRHRQ--RRSLNSEHDTQAAD------LHLLLPLANETLHLELMAHSYFLAPNLVVERHRR 126
            ....|.|.:  |..|:.|.:|....      |:..:.:..:.|||.|..:...:||...|| .:.
Mouse    62 APSPRSHLRVARSPLSLERETPRPGGPRQHFLYFNVTVFGKLLHLRLQPNRRLVAPGAPVE-WQE 125

  Fly   127 DLRT--RSPLTTRHLNCHFHGKVRGQPATNVAISTCAGLVGHIRTAGNEYFIEP-SKEHEPHPVN 188
            |.|.  |.||   ...|.:.|.|.|.|...||||.|.||.|.|||..::||||| .:..:.....
Mouse   126 DFRELFRQPL---QQECVYTGGVTGMPGAAVAISNCDGLAGLIRTDNSDYFIEPLERGQQEKEAG 187

  Fly   189 GHPHVVFQRSSVKPKHSLRKRNKRKRGGKSGSGAEVSNCGTREPRRRMETRLEWQARGKVKVQGG 253
            |..|||::|.:|                                      :.||:
Mouse   188 GRTHVVYRREAV--------------------------------------QREWK---------- 204

  Fly   254 RQIRRHHHHHHHHHHKHKYRHHQQKISRVPHTKFKYETQFQTEPDHAEIPRRRRSISSP--RHVE 316
                    ..|...|...:     .:..:|:.       .....|......|:|..:.|  ..:|
Mouse   205 --------EPHGDLHNEAF-----GLGDLPNV-------LDLVGDRLGDAERKRRHAKPGSYSIE 249

  Fly   317 TLIVADATMSAFH--RDLNGYLLTIMNMVSALYKDPSIGNSIEIVVVRIIQLDEEESQLQLNLTQ 379
            .|:..|.::..||  .....|:||:||:|..:|.|.|:|..:.|.:||:|.:...:| |.|....
Mouse   250 VLLAVDDSVVRFHGREHTQNYVLTLMNIVDEIYHDESLGAHVNIALVRLIMVGYRQS-LSLIERG 313

  Fly   380 NAQKNLDRFCSWQHKLNKGSEKDPHHHDVAILITRKNICANNCMTLGLANVGGMCKPKQSCSVNE 444
            |..::|::.|.|.|...:.......|||..|.:||:|...:     |.|.|.|||.|.:||::|.
Mouse   314 NPARSLEQVCRWAHSQQRQDPSHTEHHDHVIFLTRQNFGPS-----GYAPVTGMCHPLRSCALNH 373

  Fly   445 DNGIMLSHTITHELGHNFGMFHDTAKIGCHPRVGPIVHIMTPTFGADTLQVCWSNCSRKYITHFL 509
            ::|...:..:.||.||..||.||....||..... :..:|.|...|...:..||.||:..::.:|
Mouse   374 EDGFSSAFVVAHETGHVLGMEHDGQGNGCDDETS-LGSVMAPLVQAAFHRFHWSRCSKLELSRYL 437

  Fly   510 DQGLGEC-LDDP-----PTPLDEYNYTGELPGMRYNARGQCRLQFNLTTDSEVGACSAPHEF--C 566
            ..  .:| ||||     |.|       .||||:.|:...|||..|.    :....|.|...|  |
Mouse   438 PS--YDCLLDDPFERTWPQP-------PELPGIDYSMDEQCRFDFG----TGYHTCLAFRTFEPC 489

  Fly   567 STLWCKVNGE---CVTHMRPTAPGTLCGRNKWCQNGKCVRR--EELAAVNGGWGDWSEWSECSRS 626
            ..|||.....   |.|...|...||.|...|||..|.|:.:  |:....:|||..|:.:..||||
Mouse   490 KQLWCSHPDNPYFCKTKKGPPLDGTECAPGKWCFKGHCIWKSPEQTYGQDGGWSSWTNFGSCSRS 554

  Fly   627 CGGGVSTQQRECDNPVPANGGVFCIGERKRYKICRKRPCPAEEPSFRAQQCARFDN-VSYQGATY 690
            |||||.::.|.||||.||.||..|.|....|:||....||.....|||||||:.:: .::|.|.:
Mouse   555 CGGGVRSRSRSCDNPPPAYGGRPCSGSMFEYQICNSEDCPGPYEDFRAQQCAKRNSYYTHQDAKH 619

  Fly   691 KWLPFFDKNN--PCKLFCSDVDDTIIANWGATVLDGTPCTL-GTNNMCIDGICKKVGCDWIVDSE 752
            .|||:...::  .|:|.|...|...:......|.|||.|:. ...::|..|.|...|||..|.|.
Mouse   620 SWLPYEPDSDAQKCELICQSADTGDVVFMNQVVHDGTRCSYRDPYSVCARGECVPFGCDKEVGSM 684

  Fly   753 VQDDRCGVCGGSGDQCQPVRETYTDPFAAKDGAYVEIVTIPARARHILIRELANSPHFLAI---A 814
            ..||:||||||....|:.|:.|...  .:|..|.::.|.|||.||||.|..|..:||.:|:   .
Mouse   685 KTDDKCGVCGGDNSHCRTVKGTLGK--GSKQAAALKQVQIPAGARHIQIELLEKAPHRIAVKNQV 747

  Fly   815 TGDGGDRFYLNGDSLISMPGEFEIAGAESLYDRVDEQETITIPQPIQHSISLYAI------VRGN 873
            ||.    |..|.....:....|...|.|..::..|.::::....|:..:|::..:      .||:
Mouse   748 TGS----FIFNPKGKEASSRTFTALGLEWEHEAEDTKDSLRTNGPLPEAIAILVLPPAEGKPRGS 808

  Fly   874 ESNAGIFYEFTLPAL---NVTAGR--QFQWRLSNWTACSASCGGGVQHREPICQEN------GKA 927
            .:...:.:|..||.:   ||....  .::|.|.:|:.||.:||||:|..:..|:..      .:.
Mouse   809 LAYKYVIHEDLLPLIGSNNVLLEETDTYEWALKSWSPCSKACGGGIQFTKYGCRRRRDHHMVHRH 873

  Fly   928 LGDTLPCWTHAKNKRPARQ--------------------SRGCGD-------------------- 952
            |.|      |.|..:|.|:                    ||.||.
Mouse   874 LCD------HKKRPKPIRRRCNQHSCPQPTWVTEEWGACSRSCGKLGLQTRGVQCLLPLSNGTHK 932

  Fly   953 --------------------QPCPAHWWPGPWQFCPVTCRPVGFVAPPQRRRSVVCLDEHDVVVA 997
                                .||||.|..|.|..|..||      ....::|.|||.:....:
Mouse   933 AMPAKACLGNRPEAKKPCLRVPCPAQWRTGAWSQCSATC------GEGIQQRQVVCRNTSSAL-- 989

  Fly   998 DAECGHLQKPAEMEPCESSLPIC 1020
             ..|..: ||..::.|  |||.|
Mouse   990 -GPCEGV-KPDMVQIC--SLPAC 1008

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AdamTS-B	NP_572247.2	Pep_M12B_propep	78..194	CDD:279848	41/126 (33%)
		ZnMc_ADAMTS_like	314..518	CDD:239801	64/206 (31%)
		Reprolysin	315..521	CDD:279729	68/213 (32%)
		ADAM_CR	<558..602	CDD:301627	17/48 (35%)
		TSP1	614..666	CDD:214559	25/51 (49%)
		ADAM_spacer1	773..886	CDD:283607	29/121 (24%)
		TSP1	901..956	CDD:214559	20/120 (17%)
Adamts14	NP_001074596.1	Pep_M12B_propep	80..193	CDD:279848	38/116 (33%)
		ZnMc_ADAMTS_like	246..444	CDD:239801	64/206 (31%)
		Reprolysin	248..447	CDD:279729	66/207 (32%)
		TSP1	542..594	CDD:214559	25/51 (49%)
		ADAM_spacer1	701..816	CDD:283607	29/120 (24%)
		TSP1	836..894	CDD:214559	17/63 (27%)
		TSP1	898..956	CDD:214559	5/57 (9%)
		TSP_1	961..1008	CDD:278517	16/58 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3538
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810