DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment AdamTS-B and Adamts15

DIOPT Version :9

Sequence 1:	NP_572247.2	Gene:	AdamTS-B / 31490	FlyBaseID:	FBgn0029791	Length:	1023	Species:	Drosophila melanogaster
Sequence 2:	NP_001019310.1	Gene:	Adamts15 / 235130	MGIID:	2449569	Length:	950	Species:	Mus musculus

Alignment Length:	1050	Identity:	332/1050 - (31%)
Similarity:	468/1050 - (44%)	Gaps:	207/1050 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    45 EGQLVVPRRVHPDGAFMTHQLEYAHELDHRRHRQRRSLNSEHDTQAADLHLLLPLANETLHLELM 109
            |.::|||.|..||              .:.||..||......|   ..|...:....:..:|.|.
Mouse    22 EWEVVVPIRRDPD--------------INGRHYYRRGTEDSGD---QGLIFQITAFQQDFYLHLT 69

  Fly   110 AHSYFLAPNLVVERHRRDLR--TRSPLTTRHLNCHFHGKVRGQPATNVAISTCAGLVGHIRTAGN 172
            ..:.||||....|.....|:  |.|.|..|  .|.:.|.|..:|.:..|:|.|.||.|.....|.
Mouse    70 PDAQFLAPAFATEYLGVPLQRLTGSSLDLR--RCFYSGYVNAEPDSFAAVSLCGGLRGAFGYRGA 132

  Fly   173 EYFIEPSKEHEPHPVNGHPHVVFQRSSVKPKHSLRKRNKRKRGGKSG-SGAEVSNCGTR------ 230
            ||.|.|.      |....|..        .:||......::||...| ||...|.||..
Mouse   133 EYVISPL------PNTSAPEA--------QRHSQGAHLLQRRGAPVGPSGDPTSRCGVASGWNPA 183

  Fly   231 --------EPRRRMETRLEWQARGKVKVQGGRQIRRHHHHHHHHHHKHKYRHHQQKISRVPHTKF 287
                    :|||                .|..:                 .|::::..|.
Mouse   184 ILRALDPYKPRR----------------TGAGE-----------------SHNRRRSGRA----- 210

  Fly   288 KYETQFQTEPDHAEIPRRRRSISSPRHVETLIVADATMSAFH-RDLNGYLLTIMNMVSALYKDPS 351
                              :|.:|.||:||||:|||.:|..|| .||..||||::...:.||:.||
Mouse   211 ------------------KRFVSIPRYVETLVVADESMVKFHGADLEHYLLTLLATAARLYRHPS 257

  Fly   352 IGNSIEIVVVRIIQLDEEESQLQLNLTQNAQKNLDRFCSWQHKLNKGSEKDPHHHDVAILITRKN 416
            |.|.|.||||:::.|.:.::..:  :|.||...|..||:||.||||.|:|.|.:.|.|||.||::
Mouse   258 ILNPINIVVVKVLLLGDRDTGPK--VTGNAALTLRNFCAWQKKLNKVSDKHPEYWDTAILFTRQD 320

  Fly   417 IC-ANNCMTLGLANVGGMCKPKQSCSVNEDNGIMLSHTITHELGHNFGMFHDTAKIGCHPRVGPI 480
            :| |..|.|||:|:||.||.||:||||.||:|:..:.|..|||||.|.|.||..|: |....|.:
Mouse   321 LCGATTCDTLGMADVGTMCDPKRSCSVIEDDGLPSAFTTAHELGHVFNMPHDNVKV-CEEVFGKL 384

  Fly   481 --VHIMTPTFGADTLQV----CWSNCSRKYITHFLDQGLGEC-LDDPPTPLDEYNYTGELPGMRY 538
              .|:|:||.    :|:    .||.||...||.|||.|.|:| ||.|..|:   ....:|||..|
Mouse   385 RANHMMSPTL----IQIDRANPWSACSAAIITDFLDSGHGDCLLDQPSKPI---TLPEDLPGTSY 442

  Fly   539 NARGQCRLQFNLTTDSEVGACSAPH-EFCSTLWC--KVNGE--CVTHMRPTAPGTLCGRNKWCQN 598
            :...||.|.|.      ||:...|: ::|:.|||  |..|:  |.|...|.|.||.||..|:|..
Mouse   443 SLSQQCELAFG------VGSKPCPYMQYCTKLWCTGKAKGQMVCQTRHFPWADGTSCGEGKFCLK 501

  Fly   599 GKCVRRE--ELAAVNGGWGDWSEWSECSRSCGGGVSTQQRECDNPVPANGGVFCIGERKRYKICR 661
            |.||.|.  ....|:|.|..|..:..|||:|||||...:|:|.||.|||||.:|.|.|.:|:.|.
Mouse   502 GACVERHNPNKYRVDGSWAKWEPYGSCSRTCGGGVQLARRQCSNPTPANGGKYCEGVRVKYRSCN 566

  Fly   662 KRPCP--AEEPSFRAQQCARFDNVSYQGATYK------WLPFFDKNNP---CKLFCSDVDDTIIA 715
            ..|||  |...|||.:||..|:  .|..:|.:      |:|.:...:|   |||.|.........
Mouse   567 LEPCPSSASGKSFREEQCEAFN--GYNHSTNRLTLAVAWVPKYSGVSPRDKCKLICRANGTGYFY 629

  Fly   716 NWGATVLDGTPCTLGTNNMCIDGICKKVGCDWIVDSEVQDDRCGVCGGSGDQCQPVRETYTDPFA 780
            .....|:|||.||..:.::|:.|.|.|.|||..:.|:.:.|:||||||....|:.|...:|.|.
Mouse   630 VLAPKVVDGTLCTPDSTSVCVQGKCIKAGCDGNLGSKKKFDKCGVCGGDNKSCKRVTGLFTKPM- 693

  Fly   781 AKDGAYVEIVTIPARARHILIRE-----LANSPHFLAIATGDGGDRFYLNGDSLIS-MPGEFEIA 839
               ..|..:|.|||.|..|.||:     |....::||:....|  ::.|||..::| :..:..:.
Mouse   694 ---HGYNFVVAIPAGASSIDIRQRGYKGLIGDDNYLALKNSQG--KYLLNGHFVVSAVERDLVVK 753

  Fly   840 GAESLYDRVDEQ-ETITIPQPIQHSISLYAIVRGNESNAGIFYEFTL------------------ 885
            |:...|...... |::...:||...:::..:..|..:...:.|.|.|
Mouse   754 GSVLRYSGTGTAVESLQASRPILEPLTVEVLSVGKMTPPRVRYSFYLPKEPREDKSTRPKDPRGS 818

  Fly   886 PALN---VTAGRQFQ---------WRLSNWTACSASCGGGVQHREPICQENGKALGDTLPCWTHA 938
            |.|.   ::...|.:         |...:|..||.|||.|:|.|...|:::....|.:.....|
Mouse   819 PVLRNSVLSLSNQVEQPDNRPPARWVAGSWGPCSVSCGSGLQKRAVDCRDSPGQQGASACDVDH- 882

  Fly   939 KNKRPARQSRGCGDQPCPAHWWPGPWQFCPVTCRPVGFVAPPQRRRSVVCLDEHDVVVADAECGH 1003
               ||. :.|.|| :|||. |..|.|..|..:|.. ||     :||.:.|:.....::|..:|..
Mouse   883 ---RPL-EKRACG-EPCPT-WELGNWSPCSKSCGR-GF-----KRRPLKCVGHGGRLLARDQCDL 935

  Fly  1004 LQKPAEMEPC 1013
            .:||.|::.|
Mouse   936 RRKPQELDFC 945

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AdamTS-B	NP_572247.2	Pep_M12B_propep	78..194	CDD:279848	33/117 (28%)
		ZnMc_ADAMTS_like	314..518	CDD:239801	99/212 (47%)
		Reprolysin	315..521	CDD:279729	101/214 (47%)
		ADAM_CR	<558..602	CDD:301627	18/48 (38%)
		TSP1	614..666	CDD:214559	25/51 (49%)
		ADAM_spacer1	773..886	CDD:283607	28/137 (20%)
		TSP1	901..956	CDD:214559	18/54 (33%)
Adamts15	NP_001019310.1	Pep_M12B_propep	42..157	CDD:279848	35/133 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	144..172		8/35 (23%)
		Cysteine switch. /evidence=ECO:0000250	172..179		3/6 (50%)
		Reprolysin	218..427	CDD:279729	102/215 (47%)
		ZnMc_ADAMTS_like	218..424	CDD:239801	100/212 (47%)
		ADAM_CR	437..506	CDD:301627	29/74 (39%)
		TSP1	519..571	CDD:214559	25/51 (49%)
		ADAM_spacer1	683..801	CDD:283607	28/123 (23%)
		Spacer. /evidence=ECO:0000250	701..838		27/138 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	798..822		3/23 (13%)
		TSP1	846..895	CDD:214559	18/54 (33%)
		TSP1	897..950	CDD:214559	15/54 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3538
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D125522at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100241
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.720