DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment AdamTS-B and Adamts17

DIOPT Version :9

Sequence 1:	NP_572247.2	Gene:	AdamTS-B / 31490	FlyBaseID:	FBgn0029791	Length:	1023	Species:	Drosophila melanogaster
Sequence 2:	NP_001029049.2	Gene:	Adamts17 / 233332	MGIID:	3588195	Length:	1122	Species:	Mus musculus

Alignment Length:	1074	Identity:	325/1074 - (30%)
Similarity:	477/1074 - (44%)	Gaps:	215/1074 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 LGLLLHYWLVVVTQGGGVRPLYGLHSDELV---AGEGQLVVPRRVHPDGAFMTHQLEYAHELDHR 74
            |.|||..|              ||.....|   |.:.::|:|||:.|:...: ..|..|..|  |
Mouse    12 LSLLLLVW--------------GLDPGTAVGDAAADVEVVLPRRLRPEDVHL-QLLPGAAGL--R 59

  Fly    75 RHRQRRSLNSEHDTQAADLHLL--LPLANETLHLELMAHSYFLAPNLVVERHRRDLRTRSPLTTR 137
            |.|:.|:....|.....:..||  ||.....|:|:|.....||:|...||......|:..|...
Mouse    60 RWRRPRASPGGHRAGQGERALLLHLPAFGRDLYLQLHRDLRFLSPGFEVEEAGVSGRSGHPAEL- 123

  Fly   138 HLNCHFHGKVRGQPATNVAISTC---AGLVGHIRTAGNEYFIEPSKEHEPHPVNGHPHVVFQRSS 199
               |.:.|:|.|.|.:.|::|.|   .||||.|:....:.||:|... ...|..|..|::
Mouse   124 ---CFYSGRVLGHPGSLVSLSACGAAGGLVGLIQLEQEQVFIQPLNS-SGGPFIGREHLI----- 179

  Fly   200 VKPKHSLRKRNKRKRGGKSGSGAEVSNCGTREPRRRMETRLEWQARGKVKVQGGRQIRRHHHHHH 264
                       :||.........||..     ||:|            .||...::.|:.|
Mouse   180 -----------RRKWASTPSPATEVEG-----PRQR------------CKVVTEKKPRKDH---- 212

  Fly   265 HHHHKHKYRHHQQKISRVPHTKFKYETQFQTEPDHAEIPRRRRSI--SSPRHVETLIVADATMSA 327
                          :||                |..|   ||.:|  ::...||||:||||.|..
Mouse   213 --------------LSR----------------DWRE---RRNAIRLTNEHTVETLVVADADMVQ 244

  Fly   328 FH--RDLNGYLLTIMNMVSALYKDPSIGNSIEIVVVRIIQLDEEESQLQLNLTQNAQKNLDRFCS 390
            :|  .....::||:||||..:::..|:|..|.|.|.:::.|.:..::|.:.  .:.:::|:.||.
Mouse   245 YHGAEAAQRFILTVMNMVYNMFQHRSLGIKINIQVTKLVLLRQRPAKLSIG--HHGERSLESFCH 307

  Fly   391 WQHK---------LNK--GSEKDPHHHDVAILITRKNICANN---CMTLGLANVGGMCKPKQSCS 441
            ||::         .|:  |.:.|....|.|:.:||.:.|.:.   |.|:|:|.:||:|..|:.|.
Mouse   308 WQNEEYGGARYLGNNQVPGGKDDTPPVDAAVFVTRTDFCVHKDEPCDTVGIAYLGGVCSAKRKCV 372

  Fly   442 VNEDNGIMLSHTITHELGHNFGMFHDTAKIGCHPRVGPIVHIMTPTF--GADTLQVCWSNCSRKY 504
            :.||||:.|:.||.||||||.||.||.....|..|    .|||:..:  |.:...:.||:|||..
Mouse   373 LAEDNGLNLAFTIAHELGHNLGMNHDDDHSSCAGR----SHIMSGEWVKGRNPSDLSWSSCSRDD 433

  Fly   505 ITHFLDQGLGECL--DDPPTPLDEYNYTGELPGMRYNARGQCRLQFNLTTDSEVGAC-SAPHEFC 566
            :.:||...:..||  .||.:. .......:||||.|:|..||::.|.    :....| :..|..|
Mouse   434 LENFLKSKVSTCLLITDPRSQ-HALRLPHKLPGMHYSANEQCQILFG----TNATFCKNMEHLMC 493

  Fly   567 STLWCKVNGE--CVTHMRPTAPGTLCGRNKWCQNGKCVRREELAA-VNGGWGDWSEWSECSRSCG 628
            :.|||.|.|:  |.|.:.|...||.||.:|||:.|:||.:..:.. |:|.|..||.||.|||:||
Mouse   494 AGLWCLVEGDTSCKTKLDPPLDGTECGADKWCRAGECVSKTPIPEHVDGDWSLWSAWSMCSRTCG 558

  Fly   629 GGVSTQQRECDNPVPANGGVFCIGERKRYKICRKRPCPAEEPSFRAQQCARFDNVSYQGATYKWL 693
            .|...:||:||||.|..||..|.|....:..|.|.|||...||||.|||...|.:|.:.......
Mouse   559 TGARFRQRKCDNPPPGPGGTHCQGASVEHAACEKLPCPKGVPSFRDQQCQAHDRLSSKKRGLLTA 623

  Fly   694 PFFDKNNPCKLFCSDV---DDTIIANWGATVLDGTPCTLGTNNMCIDGICKKVGCDWIVDSEVQD 755
            ...| :.||:|:||.:   ...::|:   .|||||||.....::|:.|.|:|:|||.|:.|..::
Mouse   624 VVVD-DKPCELYCSPLGKESPLLVAD---RVLDGTPCGPYEADLCVYGRCQKIGCDGIIGSAAKE 684

  Fly   756 DRCGVCGGSGDQCQPVRETYTDPFAAKDGAYVEIVTIPARARHILIRELANSPHFLAIATGDGGD 820
            ||||||.|.|..|:.|:..::.   ::...|:|.|.||..||.|.:.|...:..|||:.  |...
Mouse   685 DRCGVCSGDGKTCRVVKGDFSH---SRGTGYIEAVVIPVGARRIRVVEDKPAHSFLALK--DSSK 744

  Fly   821 RFYLNGDSLISMPGEFEIAGA------ESLYDRVDEQETITIPQPIQHSISLYAIVRGNESNAGI 879
            | .:|.|..|.:||||:|||.      ..|:::...:...|:|..:.       ::..::.|.||
Mouse   745 R-SINSDWKIELPGEFQIAGTTVRYVRRGLWEKFSAKGPTTVPLHLM-------VLLFHDQNYGI 801

  Fly   880 FYEFTLPALNVTAGRQ----------FQWRLSNWTACSASCGGGVQHREPICQENGKALGDTLPC 934
            .||:|:| :|.::..|          |.|..|.|..||..||||.:.              |:..
Mouse   802 HYEYTIP-VNQSSENQSEPAKPQDALFLWTHSGWEGCSVQCGGGERR--------------TIVS 851

  Fly   935 WTHAKNK--------------RPARQSRGCGDQPCPAHWWPGPWQFCPVTCRPVGFVAPPQRRRS 985
            .|...||              ||..|.|.|...||.:.|..|.|..|..||.      ...:.|.
Mouse   852 CTRIVNKTTTLVNDSDCPQASRPEPQVRRCNSHPCQSRWVTGQWSPCSATCE------KGVQHRE 910

  Fly   986 VVCLDE-----HDVVVADAECGHLQKPAEMEPCE 1014
            |.|:.:     | |......|.. .:|..::.||
Mouse   911 VTCVYQLQNGTH-VTTRPIYCSE-PRPTPVQSCE 942

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AdamTS-B	NP_572247.2	Pep_M12B_propep	78..194	CDD:279848	35/120 (29%)
		ZnMc_ADAMTS_like	314..518	CDD:239801	77/223 (35%)
		Reprolysin	315..521	CDD:279729	78/225 (35%)
		ADAM_CR	<558..602	CDD:301627	19/46 (41%)
		TSP1	614..666	CDD:214559	25/51 (49%)
		ADAM_spacer1	773..886	CDD:283607	33/118 (28%)
		TSP1	901..956	CDD:214559	18/68 (26%)
Adamts17	NP_001029049.2	Pep_M12B_propep	75..179	CDD:279848	33/108 (31%)
		Reprolysin	230..447	CDD:279729	76/222 (34%)
		ZnMc_ADAMTS_like	230..447	CDD:239801	76/222 (34%)
		TSP1	544..596	CDD:214559	25/51 (49%)
		ADAM_spacer1	698..808	CDD:283607	34/122 (28%)
		TSP_1	892..946	CDD:278517	14/59 (24%)
		TSP1	950..994	CDD:214559
		TSP1	1001..1053	CDD:214559
		PLAC	1080..1106	CDD:285849
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	65	1.000	Domainoid score	I10002
eggNOG	1	0.900	-	-		E1_KOG3538
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D125522at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR13723
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.920