DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment AdamTS-B and Adamts10

DIOPT Version :9

Sequence 1:	NP_572247.2	Gene:	AdamTS-B / 31490	FlyBaseID:	FBgn0029791	Length:	1023	Species:	Drosophila melanogaster
Sequence 2:	NP_766207.2	Gene:	Adamts10 / 224697	MGIID:	2449112	Length:	1104	Species:	Mus musculus

Alignment Length:	1051	Identity:	339/1051 - (32%)
Similarity:	484/1051 - (46%)	Gaps:	166/1051 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 WLVVVTQGGGVRPLYGLHS-DELVAG--EGQLVVPRRVHPDGAFMTHQLEYAHELDHRRHRQRRS 81
            |.:.:..|...:..:...| |||::.  ..::..|.||..:||.:...       .....||||.
Mouse    10 WALALGLGLTFKVTHAFRSQDELLSSLESYEIAFPTRVDHNGAMLAFS-------PPAFRRQRRG 67

  Fly    82 LNSEHDTQ------AADLHLLLPLANETLHLELMAHSYFLAPNLVVERHRRDLRTRSPLT---TR 137
            ..:..:::      |...|.||.|..              :|.|:......:..||..|.   ..
Mouse    68 AGATTESRLFYKVAAPSTHFLLNLTR--------------SPRLLAGHVSVEYWTREGLAWQRAA 118

  Fly   138 HLNCHFHGKVRGQP-ATNVAISTCAGLVGHIRTAGNEYFIEP----SKEHEPHPVNGHPHVVFQR 197
            ..:|.:.|.::||. :::||:|||.||.|.|.....||.|||    .|.|. .|....||||::|
Mouse   119 RAHCLYAGHLQGQAGSSHVAVSTCGGLHGLIVADDEEYLIEPLQGGPKGHR-GPEESGPHVVYKR 182

  Fly   198 SSVKPKHSLRKRNKRKRGGKSGSGAEVSNCGTREPRRRMETRLEWQAR----GKVKVQGGRQIRR 258
            ||::..|.                  .:.||.|:.:       .|:.|    ..:|....|.:
Mouse   183 SSLRHPHL------------------DTACGVRDEK-------PWKGRPWWLRTLKPPPARPL-- 220

  Fly   259 HHHHHHHHHHKHKYRHHQQKISRVPHTKFKYETQFQTEPDHAEIPRRRRSISSPRHVETLIVADA 323
                                               ..|.:..:: ..:||:|..|:||||:|||.
Mouse   221 -----------------------------------GNESERGQL-GLKRSVSRERYVETLVVADK 249

  Fly   324 TMSAFH--RDLNGYLLTIMNMVSALYKDPSIGNSIEIVVVRIIQLDEEESQLQLNLTQNAQKNLD 386
            .|.|:|  ||:..|:|.|||:|:.|::|.|:||.:.|:|.|:|.|.|::..|:  :|.:|.|:||
Mouse   250 MMVAYHGRRDVEQYVLAIMNIVAKLFQDSSLGNIVNILVTRLILLTEDQPTLE--ITHHAGKSLD 312

  Fly   387 RFCSWQHKL-------NKGSEKDPHHHDVAILITRKNICA---NNCMTLGLANVGGMCKPKQSCS 441
            .||.||..:       |...|....:||.|:||||.:||.   ..|.|||||.|||||:.::|||
Mouse   313 SFCKWQKSIVSHSGHGNAIPENGVANHDTAVLITRYDICIYKNKPCGTLGLAPVGGMCERERSCS 377

  Fly   442 VNEDNGIMLSHTITHELGHNFGMFHDTAKIGCHPRVGPIVHIMTPTFGADTLQVCWSNCSRKYIT 506
            :|||.|:..:.||.||:||.|||.||....||..|......:|.......|....||:|||.|||
Mouse   378 INEDIGLATAFTIAHEIGHTFGMNHDGVGNGCGARGQDPAKLMAAHITMKTNPFVWSSCSRDYIT 442

  Fly   507 HFLDQGLGECLDDPPTPLDEYNYTGELPGMRYNARGQCRLQFNL-TTDSEVGACSAPHEFCSTLW 570
            .|||.|||.||::.| |..::.|....||..|:|..|||.|..: :...:.|      |.||.||
Mouse   443 SFLDSGLGLCLNNRP-PRQDFVYPTVAPGQAYDADEQCRFQHGVKSRQCKYG------EVCSELW 500

  Fly   571 C-KVNGECVTHMRPTAPGTLCGRNK----WCQNGKCV---RREELAAVNGGWGDWSEWSECSRSC 627
            | ..:..|:|:..|.|.||||..:.    ||....||   .|.|  .|:|.||.|:.|.:|||||
Mouse   501 CLSKSNRCITNSIPAAEGTLCQTHTIDKGWCYKRVCVPFGSRPE--GVDGAWGPWTPWGDCSRSC 563

  Fly   628 GGGVSTQQRECDNPVPANGGVFCIGERKRYKICRKRPCPAEEPSFRAQQCARFDNVSYQGATYKW 692
            |||||:..|.||:|.|..||.:|:|||:|::.|....||.....||..||:.||:|.::|..|.|
Mouse   564 GGGVSSSSRHCDSPRPTIGGKYCLGERRRHRSCNTNDCPPGSQDFREMQCSEFDSVPFRGKFYTW 628

  Fly   693 LPFFDKN-NPCKLFCSDVDDTIIANWGATVLDGTPCTLGTNNMCIDGICKKVGCDWIVDSEVQDD 756
            ..:.... ..|.|.|............|.|:|||||...|.::|:.|.||.||||.::.|::::|
Mouse   629 KTYRGGGVKACSLTCLAEGFNFYTERAAAVVDGTPCRPDTVDICVSGECKHVGCDRVLGSDLRED 693

  Fly   757 RCGVCGGSGDQCQPVRETYTDPFAAKDGAYVEIVTIPARARHILIRELANSPHFLAIATGDGGDR 821
            :|.||||.|..|:.:...::.  |.....|.::|.||..:.||.|::|..|...||: .|| .:.
Mouse   694 KCRVCGGDGSACETIEGVFSP--ALPGTGYEDVVWIPKGSVHIFIQDLNLSLSHLAL-KGD-QES 754

  Fly   822 FYLNGDSLISMPGEFEIAGAE-SLYDRVDEQETITIPQPIQHSISLYAIVRGNESNAGIFYEFTL 885
            ..|.|......|....:||.. .|....|:.:::....||  :.||..:|........:.|.|..
Mouse   755 LLLEGLPGTPQPHRLPLAGTTFHLRQGPDQAQSLEALGPI--NASLIIMVLAQAELPALHYRFNA 817

  Fly   886 PALNVTAGRQFQWRLSNWTACSASCGGGVQHREPIC--QENGKALGDTLPCWTHAKNKRPARQSR 948
            |... .|...:.|..:.||.|||.|.||.|.:...|  |.:..|:.   |.:....:|.|.|| |
Mouse   818 PIAR-DALPPYSWHYAPWTKCSAQCAGGSQVQVVECRNQLDSSAVA---PHYCSGHSKLPKRQ-R 877

  Fly   949 GCGDQPCPAHWWPGPWQFCPVTCRPVGFVAPPQRRRSVVCLDE----HDVVVADAECGHLQKPAE 1009
            .|..:|||..|..|.|..|..:| ..|.     |.|||||...    .:..:.|:.|.. .:|..
Mouse   878 ACNTEPCPPDWVVGNWSRCSRSC-DAGV-----RSRSVVCQRRVSAAEEKALDDSACPQ-PRPPV 935

  Fly  1010 MEPCESSLPIC 1020
            :|.|:.  |:|
Mouse   936 LEACQG--PMC 944

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AdamTS-B	NP_572247.2	Pep_M12B_propep	78..194	CDD:279848	36/129 (28%)
		ZnMc_ADAMTS_like	314..518	CDD:239801	99/215 (46%)
		Reprolysin	315..521	CDD:279729	100/217 (46%)
		ADAM_CR	<558..602	CDD:301627	16/48 (33%)
		TSP1	614..666	CDD:214559	27/51 (53%)
		ADAM_spacer1	773..886	CDD:283607	28/113 (25%)
		TSP1	901..956	CDD:214559	20/56 (36%)
Adamts10	NP_766207.2	Pep_M12B_propep	64..179	CDD:279848	36/129 (28%)
		Reprolysin	239..457	CDD:279729	101/219 (46%)
		ZnMc_ADAMTS_like	239..454	CDD:239801	100/216 (46%)
		TSP1	550..602	CDD:214559	27/51 (53%)
		ADAM_spacer1	706..818	CDD:283607	28/117 (24%)
		Spacer. /evidence=ECO:0000250	706..818		28/117 (24%)
		TSP1	829..885	CDD:214559	21/59 (36%)
		TSP1	952..1003	CDD:214559
		TSP1	1007..1054	CDD:214559
		PLAC	1070..1102	CDD:285849
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	212	1.000	Domainoid score	I2766
eggNOG	1	0.900	-	-		E1_KOG3538
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D125522at2759
OrthoFinder	1	1.000	-	-		FOG0001196
OrthoInspector	1	1.000	-	-		otm42682
orthoMCL	1	0.900	-	-		OOG6_100241
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	6.720