Protein Alignment AdamTS-B and Adamts20

DIOPT Version :10

• Sequence 1: NP_572247.2
• Gene: AdamTS-B / 31490
• FlyBaseID: FBgn0029791
• Length: 1023
• Species: Drosophila melanogaster
• Sequence 2: XP_006520926.1
• Gene: Adamts20 / 223838
• MGIID: 2660628
• Length: 1915
• Species: Mus musculus
• Alignment Length: 1137
• Identity: 325/1137 - (28%)
• Similarity: 476/1137 - (41%)
• Gaps: 277/1137 - (24%)

  Fly    47 QLVVPRRVHPDGAFMTHQLEYAHELDHRRH--RQRRSLNSEHDTQAADLHLLLPLANETLHLELM 109
            ::|.|.||:          |:.......||  |::|| :...:......|..:....:...|.|.
Mouse    50 EVVTPTRVN----------EFGDVFPQNRHFSRKKRS-SGVPEPPPFRTHYRISAYGQLFQLNLS 103

  Fly   110 AHSYFLAPNLVVERH-------RRDLRTRSPLTTRHLNCHFHGKVRGQPATNVAISTCAGLVGHI 167
            |.:.|||.. ..|.|       .....|.|| ..||  |.:.|:|..:.......|.|.||:|..
Mouse   104 ADAAFLAAG-YTEVHLGTPVPGPGGRSTESP-DLRH--CFYRGQVNAREDHTAVFSLCGGLMGTF 164

  Fly   168 RTAGNEYFIEP------SKEHEPHPVNGHPHVVFQRSSVKPKHSLRKRNKRKRGGKSGSGAEVSN 226
            :....|||:||      |...:.|   ..||:::           |:..||....:|....|||
Mouse   165 KANDGEYFLEPVLRADGSAHDDDH---NKPHLIY-----------RQELKRNSFARSHKPCEVS- 214

  Fly   227 CGTREPRRRME-TRLEWQA----RGKVKVQGGRQIRRHHHHHHHHHHKHKYRHHQQKISRVPHTK 286
                  ..:|| |.|..|:    .|.|.::
Mouse   215 ------ENQMEKTALPSQSSRNTTGDVDIE----------------------------------- 238

  Fly   287 FKYETQFQTEPDHAEI-PRRRRSISSPRHVETLIVADATMSAFH-RDLNGYLLTIMNMVSALYKD 349
              .|..|:.|.:.::: .|.:|.:|.||:||.::.|||.|...| ::|..|:||:|::|:|:|||
Mouse   239 --EEAVFRLEGERSQLHSRNKRFLSYPRYVEVMVTADAKMVHHHGQNLQHYVLTLMSIVAAIYKD 301

  Fly   350 PSIGNSIEIVVVRIIQLDEEESQLQLNLTQNAQKNLDRFCSWQHKLNKGSEKDPHHHDVAILITR 414
            .||||.|.||:|:::.:..|:....::.  ||...|..||.||...|...:..|.|||.|:||||
Mouse   302 SSIGNLINIVIVKLVVIHSEQEGPVISF--NAATTLRNFCLWQQSQNVPDDAHPSHHDTAVLITR 364

  Fly   415 KNICA--NNCMTLGLANVGGMCKPKQSCSVNEDNGIMLSHTITHELGHNFGMFHDTAKIGCHPRV 477
            ::||.  ..|.|||||.:|.:|.|.:|||::|:||:..:.||.|||||.|.:.||.:.......:
Mouse   365 EDICGAKEKCDTLGLAELGTLCDPSRSCSISEENGLSAAFTIAHELGHVFNVPHDDSFKCKEAGI 429

  Fly   478 GPIVHIMTPTFGADTLQVCWSNCSRKYITHFLDQGLGECLDDPPTPLDEYNYTGELPGMRYNARG 542
            ....|:|.||....|....||.||:|:||.|||.|.||||.|.|.. ..|:.:.:|||..|:...
Mouse   430 KHQYHVMAPTLNYHTSPWTWSACSQKHITEFLDTGHGECLLDKPNG-RTYDLSPQLPGSVYDGNR 493

  Fly   543 QCRLQFNLTTDSEVGACSAPH-EFCSTLWCK----VNGECVTHMRPTAPGTLCGRNKWCQNGKCV 602
            ||.|.|.      .|:...|: :.|..|||.    |:..|.|...|.|.||.||....|..|.||
Mouse   494 QCELMFG------PGSQVCPYLKHCRRLWCTSAEGVHKGCRTQHMPLADGTSCGPGMHCHRGLCV 552

  Fly   603 RRE-ELAAVNGGWGDWSEWSECSRSCGGGVSTQQRECDNPVPANGGVFCIGERKRYKICRKRPCP 666
            .|: |...|:|.||.|..:|.|||:||||:.:..|.||.|.|.|||.:|:|.|.:::.|....||
Mouse   553 TRDMETRPVDGEWGPWGPYSSCSRTCGGGIKSTARLCDRPEPRNGGRYCVGRRMKFRSCNTDSCP 617

  Fly   667 AEEPSFRAQQCARFD----NVSYQGATYKWLPFFD---KNNPCKLFCSDVDDTIIANWGATVLDG 724
            ..:..||.:||:.||    :::......:|||.:.   ..:.|||:|.....|........|.||
Mouse   618 KGKRDFREKQCSDFDGKHFDINGLPPNVRWLPKYSGIAVKDRCKLYCRVAGTTSFYQLKDRVADG 682

  Fly   725 TPCTLGTNNMCIDGICKKVGCDWIVDSEVQDDRCGVCGGSGDQCQPVRETYTDPFAAKDGAYVEI 789
            |||...||::|:.|:|::.|||.:::|:.:.|:||||||....||    |....|.:....|..:
Mouse   683 TPCGTETNDICVQGLCRQAGCDHVLNSKAKRDKCGVCGGDNSSCQ----TLAGVFNSAHYGYNVV 743

  Fly   790 VTIPARARHILIRELANS-----PHFLAIATGDGGDRFYLNGDSLISMPGE--------FEIAGA 841
            |.|||.|.:|.|.:.:.|     .::||::...|  .|.|||:.::||..:        ||.:|:
Mouse   744 VKIPAGATNIEILQHSYSGRPEDDNYLALSDTQG--NFLLNGNFVVSMAKKEINIQGAVFEYSGS 806

  Fly   842 ESLYDRVDEQETITIPQPIQHSISLYAIVRGNESNAGIFYEFTLP-------------------- 886
            .:..:|::..:.      ::..:.|..:..||..|..:.|.|.:|
Mouse   807 NNSIERINSTDR------LEAELVLQVLCVGNLYNPDVRYSFNIPIEERSNLFSWDPYGPWQDCT 865

  Fly   887 --------------------------------ALNVT---------------------------- 891
                                            .|.||
Mouse   866 KMCQGLHRRKIACVRKSDHAVVSDHNCGHLPMPLFVTEKCNMDCELRWHIIGKSDCSSQCGQGYR 930

  Fly   892 ------------------AGRQF--------------------QWRLSNWTACSASCGGGVQHRE 918
                              .|.|:                    :|..|.|:.||.|||||.:.||
Mouse   931 TLDVHCMKYSVHKGQAVPVGDQYCGDQLKPPSREPCHGSCVLTRWHYSEWSQCSRSCGGGDKTRE 995

  Fly   919 PICQEN-GKALGDTLPCWTHAKNKRPARQSRGCGDQPCPAHWWPGPWQFCPVTCRPVGFVAPPQR 982
            ..|... |..|.:: .|     .:.|......|.:.|||: |....|..|||||      ....:
Mouse   996 SYCVNGFGHRLAES-EC-----RELPRVVLENCNEFPCPS-WATSEWSECPVTC------GKGMK 1047

  Fly   983 RRSVVCLDEHDVVVADAECGHLQKPAEMEPCE 1014
            :|.|.|....| .:.|..|....||..:.|||
Mouse  1048 QRQVWCQLSED-PMRDGFCNASTKPESLRPCE 1078

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
AdamTS-B	NP_572247.2	Pep_M12B_propep	47..195	CDD:460254	41/162 (25%)
		ZnMc_ADAMTS_like	314..518	CDD:239801	89/206 (43%)
		ADAMTS_CR_2	534..602	CDD:465496	24/72 (33%)
		TSP1	614..666	CDD:214559	23/51 (45%)
		ADAMTS_CR_3	672..768	CDD:437068	36/102 (35%)
		ADAMTS_spacer1	770..886	CDD:461796	30/128 (23%)
		TSP1	901..956	CDD:214559	18/55 (33%)
		TSP1_ADAMTS	959..1020	CDD:465950	18/56 (32%)
Adamts20	XP_006520926.1	Pep_M12B_propep	50..195	CDD:460254	41/162 (25%)
		ZnMc_ADAMTS_like	264..470	CDD:239801	90/207 (43%)
		ADAMTS_CR_2	485..552	CDD:465496	24/72 (33%)
		TSP1	565..617	CDD:214559	23/51 (45%)
		ADAMTS_CR_3	622..726	CDD:437068	36/103 (35%)
		ADAMTS_spacer1	728..845	CDD:461796	30/124 (24%)
		TSP1_ADAMTS	855..906	CDD:465950	3/50 (6%)
		TSP1_ADAMTS	913..966	CDD:465950	2/52 (4%)
		TSP1_ADAMTS	975..1027	CDD:465950	18/57 (32%)
		TSP1_ADAMTS	1030..1082	CDD:465950	18/56 (32%)
		TSP1_ADAMTS	1085..1139	CDD:465950
		TSP1_ADAMTS	1161..1213	CDD:465950
		TSP1_ADAMTS	1216..1268	CDD:465950
		TSP1_ADAMTS	1313..1364	CDD:465950
		TSP1_ADAMTS	1367..1419	CDD:465950
		TSP1_ADAMTS	1425..1478	CDD:465950
		TSP1_ADAMTS	1481..1534	CDD:465950
		TSP1_ADAMTS	1539..1592	CDD:465950
		TSP1_ADAMTS	1663..1714	CDD:465950
		GON	1718..1914	CDD:462559