DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment AdamTS-B and adt-1

DIOPT Version :9

Sequence 1:	NP_572247.2	Gene:	AdamTS-B / 31490	FlyBaseID:	FBgn0029791	Length:	1023	Species:	Drosophila melanogaster
Sequence 2:	NP_510116.2	Gene:	adt-1 / 181412	WormBaseID:	WBGene00000082	Length:	1461	Species:	Caenorhabditis elegans

Alignment Length:	1046	Identity:	241/1046 - (23%)
Similarity:	378/1046 - (36%)	Gaps:	293/1046 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    69 HELDHRRHRQRRSLNSEHDT-------------QAADLHLLLPLANETLHLELMAHSYFLAPNLV 120
            |.|:....:|...::::||.             :..:|.:.....|:|.||.|..:|..::|:::
Worm    24 HHLNEEELKQVFGVSNKHDVPEYSLIEATRHPLKNGNLKMKFTAWNDTYHLNLRKNSRIVSPHII 88

  Fly   121 -VERHRRDLRTRSPLTTRHLNCHFHGKVRGQPATNVAISTCAGLVGHIRTAGNEYFIEPSKEHEP 184
             |.||..|..|.......:..||:.|:|:.......|||.|..|:|.| ...:.:.:..:.....
Worm    89 SVVRHGDDDVTTYAGLRDYEQCHYQGEVKSHGNMKAAISDCGALMGSI-VMEDHFLVLQTLPKRV 152

  Fly   185 HPVNGHPHVVFQRSS---VKPKHSLRKRNKRKRGGKSGSGAEVSNCGTREPRRRMETRLEWQARG 246
            |.:....|:|::||:   ...:..:|:...|.:      ..:.|.|.|.|       :|:..|
Worm   153 HHLQKERHLVYKRSAGLLTNAESKIREEITRLQ------EEQESFCDTSE-------QLDDPA-- 202

  Fly   247 KVKVQGGRQIRRHHHHHHHHHHKHKYRHHQQKISRVPHTKFKYETQF---QTEPDHAEIPRRRRS 308
                   ..|..|.|.::                .:| |..:.::.|   ..:|...||   ...
Worm   203 -------MTIPAHLHFNY----------------TIP-TSAQLDSSFIFPNMDPITLEI---GLF 240

  Fly   309 ISSP--RHVETLIVADATMSAFHRDLNGYLLTIMNMVSALYKDPSIGNSIEIVVVRIIQLDEEES 371
            :.|.  .|.|...:.||     .:.|..:.|.::|.|..||:..::..:::||:||......:.|
Worm   241 LDSKLFEHFEREYIQDA-----EQHLLEFSLALINNVHVLYQQDTLTPNLDIVIVRYEMWRTQPS 300

  Fly   372 QLQLNLTQN--AQKNLDRFCSWQHKLNKGSE-KDPHHHDVAILITRKNICANNCMTLGLANVGGM 433
            .|...:.:|  ||..||.||.:|..:|.|:: .|.:|:|..:|:|..:|........|:|.|..|
Worm   301 ALSTGVHKNGQAQSLLDAFCRYQAHMNPGTDLTDMNHYDHGVLLTGYDIYHTTTSVAGVAPVARM 365

  Fly   434 CKPKQSCSVNEDNGIMLSHTITHELGHNFGMFHDTAKIGCHPRVGPIVHIMTPTFGADTLQVCWS 498
            |.|..:||:.|...:..|..:.||:|||.||.||..:..|:..    ..:|:...||.  :..||
Worm   366 CDPLFACSLVEGLHLGRSFVLAHEMGHNMGMVHDGVQNQCNKG----CCLMSAVNGAG--KTTWS 424

  Fly   499 NCSRKYITHFL----DQGLGECLDDPPTPLDEYNYTGE--LPGMRYNARGQCRLQFNLTTDSEVG 557
            :||.:....||    :.|.|.||.|....|...|:..:  |||.|:.|..||...:......|:.
Worm   425 DCSVREFNAFLLQLDESGRGNCLRDASPGLISTNHLSDLRLPGQRFTADQQCSYFWGRDYKVEIP 489

  Fly   558 ACSAPHEFCSTLWCKVNGECVTHMRPTAPGTLCGRNKWCQNGKCVRREELAAVNGGW-------- 614
            ...|..:.|..|||..:|..::...|...|:.||.||||..|:|..          |
Worm   490 NGKAMDDICRILWCGNSGSTISTAHPALEGSWCGANKWCHKGQCTH----------WTFGLTPVP 544

  Fly   615 --GDWSEWSECSRSC-------GGGVST--QQRECDNPVPANGGVFCIGERKRYKICRKRPCPAE 668
              |:||||....:.|       .|.::.  |.|:|.||.|.|||..|.|...|..:|
Worm   545 IDGEWSEWGGAEKGCPIQQCAVSGSITVQGQHRDCVNPAPNNGGKTCEGANIRGIVC-------- 601

  Fly   669 EPSFRAQQCARFDNVSYQG---ATYKWLP-----------FFDKNNPCKLFCSDVDDTIIANWGA 719
              ...:..|..|....:..   ::.|:.|           |.....||:::|..:...:|.|.|
Worm   602 --GATSSNCLGFTREEFGNKICSSIKYDPHKPDQQLTGEGFEHSTQPCRVWCHLIGSELIRNKG- 663

  Fly   720 TVLDGTPCTLGTNNMCIDGICKKVGCD---------------------------W--------IV 749
            ...|||||  |.:..|:.|.|..:.||                           |        :.
Worm   664 QFPDGTPC--GFDAYCVGGQCLALSCDNKALVEQPEDCPRIEGRSVHQWEEWSSWSECSVSCGLG 726

  Fly   750 DSEVQDDRCG---VCGGSGDQCQPVRETYTDPFAAKDGAYVE--------IVTIPARARHILIRE 803
            ..||::.:|.   .|.|..::.:|......|  ..:.|.:.|        .:.:..|.|..|..:
Worm   727 GREVRERKCSSGRKCQGVSEESRPCEGVLRD--CEEFGEWKEWGSCSEKCALGVQKRFRPCLTDQ 789

  Fly   804 LA-----------------NSPHFLAIATGDGGDRFY---------LNGDSLISMPGEFEIAGAE 842
            .:                 |...:.:.:...||.|.|         .:||.|
Worm   790 CSSKHLQEERPCDNEGCWTNWDEWSSCSQSCGGGRRYRIRKCLDDKCDGDDL------------- 841

  Fly   843 SLYDRVDEQETITIPQPIQHSISLYAIVRGNESNAGIFYEFTLPALNVTAGRQFQWRLSNWTACS 907
                   |:|:....:.|..|                                  |  .:|..||
Worm   842 -------EKESCNTQKCISQS----------------------------------W--GDWLPCS 863

  Fly   908 ASCGGGVQHREPICQENGKALGDTLPCWTHAKNKRPARQSRGCGDQPCPAH-----W--WPGPWQ 965
            .|||.|.|.||.:|        |...|.|..|      |:|.|..|.||:.     |  | |.|.
Worm   864 VSCGIGFQIRERLC--------DGELCATANK------QARTCNQQQCPSAFSLSVWSEW-GEWT 913

  Fly   966 FCPVTC 971
            .|..||
Worm   914 TCSATC 919

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AdamTS-B	NP_572247.2	Pep_M12B_propep	78..194	CDD:279848	29/129 (22%)
		ZnMc_ADAMTS_like	314..518	CDD:239801	64/210 (30%)
		Reprolysin	315..521	CDD:279729	65/212 (31%)
		ADAM_CR	<558..602	CDD:301627	15/43 (35%)
		TSP1	614..666	CDD:214559	21/70 (30%)
		ADAM_spacer1	773..886	CDD:283607	18/146 (12%)
		TSP1	901..956	CDD:214559	19/54 (35%)
adt-1	NP_510116.2	Pep_M12B_propep	<64..163	CDD:307618	25/99 (25%)
		ZnMc_ADAMTS_like	234..448	CDD:239801	67/227 (30%)
		TSP1	710..752	CDD:214559	7/41 (17%)
		PTZ00441	<762..>806	CDD:240420	5/43 (12%)
		TSP1	807..851	CDD:214559	10/63 (16%)
		TSP1	855..898	CDD:214559	21/92 (23%)
		TSP1	906..952	CDD:214559	7/15 (47%)
		TSP1	1041..1082	CDD:214559
		TSP_1	<1088..1135	CDD:326556
		TSP1	1151..1200	CDD:214559
		TSP1	1206..1257	CDD:214559
		TSP1	1268..1318	CDD:214559
		TSP1	1327..1378	CDD:214559
		TSP1	1385..1435	CDD:214559
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	44	1.000	Domainoid score	I8379
eggNOG	1	0.900	-	-		E1_KOG3538
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	242	1.000	Inparanoid score	I2090
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.860