DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment AdamTS-B and adt-2

DIOPT Version :9

Sequence 1:	NP_572247.2	Gene:	AdamTS-B / 31490	FlyBaseID:	FBgn0029791	Length:	1023	Species:	Drosophila melanogaster
Sequence 2:	NP_001024532.2	Gene:	adt-2 / 181022	WormBaseID:	WBGene00000083	Length:	1020	Species:	Caenorhabditis elegans

Alignment Length:	966	Identity:	242/966 - (25%)
Similarity:	359/966 - (37%)	Gaps:	265/966 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   169 TAGNEYFIEPSKEHEPHPV-----NGHPH----VVFQRS---SVKPKHSLRK---------RNKR 212
            |.|.:...|.....|..||     ||..|    :.|.:.   |::|  :|.|         :...
Worm    30 TFGVDTHAEVPNHEEIDPVPYYHQNGSLHKLEFMAFNKKYNLSLEP--TLAKLLSSGVTVVKKNE 92

  Fly   213 KRGGKSGSGAEVSNCGTREPRRRMETRLEWQARGKVK---VQGGRQIRRHHHHHHHHHHKHKYRH 274
            |:||....|:.:.:|.......::...:. ...|::|   :..|..|..|....||.|..
Worm    93 KKGGSLDFGSTLDSCHYHHYGEKVYAAIS-NCDGRIKGTVIDDGEIIVVHPFPDHHAHRS----- 151

  Fly   275 HQQKISRVPHTKFKYET------------QFQTEPDHAE----------IPRRRRSISSPRHVET 317
             ::......|..:|.||            ...||....|          :..:|.:..|...||.
Worm   152 -KRATENGAHVVYKRETLAGEPKDFCGLDNVVTEESLVEDESAIFEDVFVTGQRLTQQSDLIVEL 215

  Fly   318 LIVADATM----SAFH-----RDLNGYLLTIMNMVSALYKDPSIGNSIEIVVVRIIQLDEEESQL 373
            .:..|..:    |:.|     |.|..|.||::|.:..:|..|:....:...|:|...|..:.|.|
Worm   216 AVFVDENLWRHFSSKHGGMADRKLQDYTLTLLNNIQIMYYQPTASPPLTFRVIRYEVLTRQPSAL 280

  Fly   374 --QLNLTQNAQKNLDRFCSWQHKLNKGSEKDPHHHDVAILITRKNI--CANNCMTLGLANVGGMC 434
              .|:...|||..|||||.:|..|   :.:|..|   ||::|..:|  .|.:....|:|.:.|||
Worm   281 AGYLHNHGNAQMYLDRFCRYQRNL---AVRDWDH---AIMLTGYDIHRGAGSRSISGIARLDGMC 339

  Fly   435 KPKQSCSVNEDNGIMLSHTITHELGHNFGMFHDTAKIGCHPRVGPIVHIMTPTFGADTLQVCWSN 499
            .|..:|::.|......:...||||||:.||.||...  |..:     |||:.:.|..  :|.||.
Worm   340 DPWNTCTLAEGLDFTSAFIGTHELGHSVGMRHDEPY--CQSK-----HIMSSSLGPG--KVTWST 395

  Fly   500 CSRKYITHFLDQ--GLGE-CL--DDPPTPLDEYNYTGELPGMRYNARGQCRL-------QFNLTT 552
            ||.:....||.:  |.|: ||  .:.|..|:  ..:...||..|:|..||.|       |.....
Worm   396 CSLRDYHQFLQRLDGRGKNCLRVSNMPNKLE--ISSNVKPGQIYDANLQCELMHGNGYQQVTPRQ 458

  Fly   553 DSEVGACSAPHEFCSTLWCKVN--GECVTHMRPTAPGTLCGRNKWCQNGKCV---RREEL----- 607
            ||..|       .|..:||..:  |..:| ..|...||.||.:||||.|:||   ...|:
Worm   459 DSYDG-------ICYMMWCGQSSFGRIIT-SHPALEGTFCGPSKWCQLGRCVPWTGTNEIQPTVQ 515

  Fly   608 ----------AAVNGGWGDWSEWSECSR-SCGG-----GVSTQQRECDNPVPANGGVFCIGERKR 656
                      :.::|.|..|.. :.||: :|.|     |::..:|.|..|.|||||..|:|...|
Worm   516 HVAPVVTTLPSRIDGSWSGWGA-TICSQCTCNGILGSVGLAIARRTCSAPYPANGGSDCVGSTSR 579

  Fly   657 YKICRKRPCPAEEPS---FRAQQC---ARFDN---VSYQGATYKWLPFFDKNNPCKLFCSDVDDT 712
            ..:| .|.|.....|   :.:.:|   .|..|   ::.:|:.....|    ...||:|| ||...
Worm   580 AVLC-SRQCGRASKSVDEYISDKCMEQKRLKNDRELTGKGSQLNRFP----QRACKVFC-DVQQH 638

  Fly   713 IIAN-----WGATVLDGTPCTLGTNNMCIDGICKKVGCDWIVDSEV--QDDRCGVCGGSGDQCQP 770
            ..:.     :|..:.|||.|  |.:..|:||.|..:.|:   ::.:  :|..|..     |.| |
Worm   639 YGSQRNYRFFGDNLPDGTSC--GYDRYCLDGECLALNCN---NNALISRDQSCPT-----DTC-P 692

  Fly   771 VRETYTDPFAAKDGAYVEIVTIPARARHILIRELANSPHFLAIATGDGGDRFYLNGDSLISMPGE 835
            :.:..:..:..:.|.:                .|..|    ..||..||   |...:...|:.|:
Worm   693 ITDQSSSVYRGQWGTW----------------SLWTS----CTATCGGG---YRKRNRACSITGQ 734

  Fly   836 FEIAGAESLYDRVDEQETITIPQPIQHSISLYAIVR-GNESNAGIFYEFTLPALNVTAGRQFQWR 899
            .|  |.|      ||.|..:       |.|..:::| |||.:.                    |
Worm   735 CE--GNE------DETEVCS-------SESCPSVLRVGNEWST--------------------W- 763

  Fly   900 LSNWTACSASCGGGVQHREPICQENGKALGDTLPCWTHAKNKRPARQSRGCGDQPCPA--HW--W 960
             :.|..||.|||.|.|.|...|....:.|....|    .||    .:.|.|.:.||.|  .|  |
Worm   764 -TEWNHCSVSCGRGSQARYRKCLSPHRTLAFDCP----EKN----IEVRSCDNGPCNAIGVWGTW 819

  Fly   961 PGPWQFCPVTCRPVGFVAPPQRRRSVVCLDEHDVVVADAECGHLQKPAEMEPCESS 1016
             |.|..|..:|.|...|.                          |:....|||:.|
Worm   820 -GGWSTCSTSCGPGTLVR--------------------------QRTCNREPCDGS 848

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AdamTS-B	NP_572247.2	Pep_M12B_propep	78..194	CDD:279848	9/33 (27%)
		ZnMc_ADAMTS_like	314..518	CDD:239801	70/221 (32%)
		Reprolysin	315..521	CDD:279729	70/223 (31%)
		ADAM_CR	<558..602	CDD:301627	15/45 (33%)
		TSP1	614..666	CDD:214559	20/57 (35%)
		ADAM_spacer1	773..886	CDD:283607	22/113 (19%)
		TSP1	901..956	CDD:214559	17/54 (31%)
adt-2	NP_001024532.2	Pep_M12B_propep	52..163	CDD:307618	22/119 (18%)
		ZnMc	211..417	CDD:320741	69/220 (31%)
		TSP1	705..751	CDD:214559	18/83 (22%)
		TSP1	760..810	CDD:214559	17/79 (22%)
		TSP1	816..860	CDD:214559	13/60 (22%)
		TSP1	866..910	CDD:214559
		TSP1	918..963	CDD:214559
		TSP1	969..1015	CDD:214559
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	242	1.000	Inparanoid score	I2090
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG49252
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.970