DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment AdamTS-B and ADAMTS19

DIOPT Version :9

Sequence 1:	NP_572247.2	Gene:	AdamTS-B / 31490	FlyBaseID:	FBgn0029791	Length:	1023	Species:	Drosophila melanogaster
Sequence 2:	NP_598377.4	Gene:	ADAMTS19 / 171019	HGNCID:	17111	Length:	1213	Species:	Homo sapiens

Alignment Length:	985	Identity:	293/985 - (29%)
Similarity:	441/985 - (44%)	Gaps:	161/985 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    84 SEHDTQAADLHLL-LPLANETLHLELMAHSYFLAPNLVVERHRRD-------LRTRSPLTTRHLN 140
            ::|.....|..|| :|..:..|:|.|.....||||...||:....       .....|.......
Human   161 AQHAEPDGDEVLLRIPAFSRDLYLLLRRDGRFLAPRFAVEQRPNPGPGPTGAASAPQPPAPPDAG 225

  Fly   141 CHFHGKVRGQPATNVAISTC-AGLVGHIRTAGNEYFIEPSKEHEPHPVNGHPHVVFQRSSVKPKH 204
            |.:.|.|...|.:..:.||| .||:|.|:...:..||||.  ::...:.||||.|:::     |.
Human   226 CFYTGAVLRHPGSLASFSTCGGGLMGFIQLNEDFIFIEPL--NDTMAITGHPHRVYRQ-----KR 283

  Fly   205 SLRKRNKRKRGGKSGSGAEVSNCGTREPRRRMETRLEWQARGKVKVQGGRQIRRHHHHHHHHHHK 269
            |:.::...|....|.....:|:.|  .||.|   ::....|||                     :
Human   284 SMEEKVTEKSALHSHYCGIISDKG--RPRSR---KIAESGRGK---------------------R 322

  Fly   270 HKYRHHQQKISRVPHTKFKYETQFQTEPDHAEIPRRRRSISSPRHVETLIVADATMSAFH--RDL 332
            :.|:..|:                                   .::||::|||..|.::|  ...
Human   323 YSYKLPQE-----------------------------------YNIETVVVADPAMVSYHGADAA 352

  Fly   333 NGYLLTIMNMVSALYKDPSIGNSIEIVVVRIIQLDEEESQLQLNLTQNAQKNLDRFCSWQHKLNK 397
            ..::|||:|||..|::..|:...:.:.|:::|.|.|...:|.:.  .:.:|.|:.||.|||: ..
Human   353 RRFILTILNMVFNLFQHKSLSVQVNLRVIKLILLHETPPELYIG--HHGEKMLESFCKWQHE-EF 414

  Fly   398 GSEKDPHHH------------DVAILITRKNICANN---CMTLGLANVGGMCKPKQSCSVNEDNG 447
            |.:.|.|..            |.|||||||:.|.:.   |.|:|:|.:.|||..|:.|.:.||||
Human   415 GKKNDIHLEMSTNWGEDMTSVDAAILITRKDFCVHKDEPCDTVGIAYLSGMCSEKRKCIIAEDNG 479

  Fly   448 IMLSHTITHELGHNFGMFHDTAKIGCHPRVGPIVHIMTPTF--GADTLQVCWSNCSRKYITHFLD 510
            :.|:.||.||:|||.|:.||..    ||.....:|||:..:  |.:...|.||.||::.:..||.
Human   480 LNLAFTIAHEMGHNMGINHDND----HPSCADGLHIMSGEWIKGQNLGDVSWSRCSKEDLERFLR 540

  Fly   511 QGLGEC-LDDPPTPLDEYNYTGELPGMRYNARGQCRLQFN-LTTDSEVGACSAPHEFCSTLWCKV 573
            .....| |...|..::......:||||.|.|..||::.|. |.:..:    ...|..|:.|||||
Human   541 SKASNCLLQTNPQSVNSVMVPSKLPGMTYTADEQCQILFGPLASFCQ----EMQHVICTGLWCKV 601

  Fly   574 NG--ECVTHMRPTAPGTLCGRNKWCQNGKCVRR----EELAAVNGGWGDWSEWSECSRSCGGGVS 632
            .|  ||.|.:.|...||.|...|||:.|:|..|    |.||      |:||.||.|||:|..|:|
Human   602 EGEKECRTKLDPPMDGTDCDLGKWCKAGECTSRTSAPEHLA------GEWSLWSPCSRTCSAGIS 660

  Fly   633 TQQRECDNPVPANGGVFCIGERKRYKICRKRPCPAEEPSFRAQQCARFD-NVSYQGATYKWLPFF 696
            :::|:|  |...:....|.|.||:|:||...||||..|.||..||..:. ..|......:|....
Human   661 SRERKC--PGLDSEARDCNGPRKQYRICENPPCPAGLPGFRDWQCQAYSVRTSSPKHILQWQAVL 723

  Fly   697 DKNNPCKLFCSDV--DDTIIANWGATVLDGTPCTLGTNNMCIDGICKKVGCDWIVDSEVQDDRCG 759
            |:..||.||||.|  :..|:.:  ..|:|||.|.....::|.:|.|:|||||.::.|..::|.||
Human   724 DEEKPCALFCSPVGKEQPILLS--EKVMDGTSCGYQGLDICANGRCQKVGCDGLLGSLAREDHCG 786

  Fly   760 VCGGSGDQCQPVRETYTDPFAAKDGAYVEIVTIPARARHILIRELANSPHFLAIATGDGGDRFYL 824
            ||.|:|..|:.::..:..   .:...|||::.|||.||.|.:.|...:..:||:.  |.|.: .:
Human   787 VCNGNGKSCKIIKGDFNH---TRGAGYVEVLVIPAGARRIKVVEEKPAHSYLALR--DAGKQ-SI 845

  Fly   825 NGDSLISMPGEFEIAGAESLYDRVDEQETITIPQPIQHSISLYAIVRGNESNAGIFYEFTLPALN 889
            |.|..|...|.|.:||....|.|....|.|:...|....:.|..:: ..:.|.|:.||:|:|:..
Human   846 NSDWKIEHSGAFNLAGTTVHYVRRGLWEKISAKGPTTAPLHLLVLL-FQDQNYGLHYEYTIPSDP 909

  Fly   890 VTAGRQ-------FQWRLSNWTACSASCGGGVQHREPICQENGKALGDTLPCWTHAKNK---RPA 944
            :...:.       |.|..::|..|.|:||||.:.....|.   |.:...:....:.|.|   :|.
Human   910 LPENQSSKAPEPLFMWTHTSWEDCDATCGGGERKTTVSCT---KIMSKNISIVDNEKCKYLTKPE 971

  Fly   945 RQSRGCGDQPCPAHWWPGPWQFCPVTCRPVGFVAPPQRRRSVVCLDEHD----VVVADAEC-GHL 1004
            .|.|.|.:|||...|....|..|..||      ....:.|.|.|..:..    :...:.:| |
Human   972 PQIRKCNEQPCQTRWMMTEWTPCSRTC------GKGMQSRQVACTQQLSNGTLIRARERDCIG-- 1028

  Fly  1005 QKPAEMEPCE 1014
            .|||..:.||
Human  1029 PKPASAQRCE 1038

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AdamTS-B	NP_572247.2	Pep_M12B_propep	78..194	CDD:279848	34/118 (29%)
		ZnMc_ADAMTS_like	314..518	CDD:239801	77/223 (35%)
		Reprolysin	315..521	CDD:279729	78/225 (35%)
		ADAM_CR	<558..602	CDD:301627	19/45 (42%)
		TSP1	614..666	CDD:214559	22/51 (43%)
		ADAM_spacer1	773..886	CDD:283607	32/112 (29%)
		TSP1	901..956	CDD:214559	17/57 (30%)
ADAMTS19	NP_598377.4	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	67	1.000	Domainoid score	I9779
eggNOG	1	0.900	-	-		E1_KOG3538
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D125522at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR13723
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.920