DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment AdamTS-B and ADAMTS18

DIOPT Version :9

Sequence 1:	NP_572247.2	Gene:	AdamTS-B / 31490	FlyBaseID:	FBgn0029791	Length:	1023	Species:	Drosophila melanogaster
Sequence 2:	NP_955387.1	Gene:	ADAMTS18 / 170692	HGNCID:	17110	Length:	1221	Species:	Homo sapiens

Alignment Length:	1018	Identity:	338/1018 - (33%)
Similarity:	509/1018 - (50%)	Gaps:	122/1018 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    35 GLHSDELVAGEGQLVVPRRVHPDGAFMTHQLEYAHELDHRRHRQRRSLNSEHDTQAADLHLLLPL 99
            ||:.|.:      .|.|..|...|:::      :|::.|...::|.:.|:.     :.||.....
Human    56 GLNDDYV------FVTPVEVDSAGSYI------SHDILHNGRKKRSAQNAR-----SSLHYRFSA 103

  Fly   100 ANETLHLELMAHSYFLAPNLVVERHRRD--LRTRSPLTTRHLNCHFHGKVRGQPATNVAISTCAG 162
            ..:.|||||.. |..|:.:.:|:...:|  ..|:.|...:   |.:.|.:|...:::||:|||||
Human   104 FGQELHLELKP-SAILSSHFIVQVLGKDGASETQKPEVQQ---CFYQGFIRNDSSSSVAVSTCAG 164

  Fly   163 LVGHIRTAGNEYFIEP-----SKEHE-PHPVNGHPHVVFQRSSVKPKHSLRKRNKRKRG----GK 217
            |.|.|||..||:.|.|     ::||. ..|...||||:::|::       .::.:|.||    |:
Human   165 LSGLIRTRKNEFLISPLPQLLAQEHNYSSPAGHHPHVLYKRTA-------EEKIQRYRGYPGSGR 222

  Fly   218 SGSGAEVSNCGTREPRRRMETRLEWQARGKVKVQGGRQIRRHHHHHHHHHHKHKYRHHQQKISRV 282
            :..|...|:.......|..|                        :||....|..:...::|.:..
Human   223 NYPGYSPSHIPHASQSRETE------------------------YHHRRLQKQHFCGRRKKYAPK 263

  Fly   283 PHTKFKYETQFQTEPDHAEIPRRRRSISSPR---HVETLIVADATMSAFH--RDLNGYLLTIMNM 342
            |.|:..| .:|.   ::....|.|||....:   :||||:|||..|...|  .::..|:||:|||
Human   264 PPTEDTY-LRFD---EYGSSGRPRRSAGKSQKGLNVETLVVADKKMVEKHGKGNVTTYILTVMNM 324

  Fly   343 VSALYKDPSIGNSIEIVVVRIIQLDEEESQLQLNLTQNAQKNLDRFCSWQHKLNKGSEKDPHHHD 407
            ||.|:||.:||:.|.:|||.:|.|::|...|.:|  .:|.::|:.||.||..|   ..|:...||
Human   325 VSGLFKDGTIGSDINVVVVSLILLEQEPGGLLIN--HHADQSLNSFCQWQSAL---IGKNGKRHD 384

  Fly   408 VAILITRKNICA---NNCMTLGLANVGGMCKPKQSCSVNEDNGIMLSHTITHELGHNFGMFHDTA 469
            .|||:|..:||:   ..|.|||.|.:.|||...:||::|||.|:.|:.||.||.||||||.||..
Human   385 HAILLTGFDICSWKNEPCDTLGFAPISGMCSKYRSCTINEDTGLGLAFTIAHESGHNFGMIHDGE 449

  Fly   470 KIGCHPRVGPIVHIMTPTFGADTLQVCWSNCSRKYITHFLDQGLGECLDDPPTPLDEYNYTGELP 534
            ...|....|   :||:||...:.....||:|||:|:..||......||.|.|....:|.|..:||
Human   450 GNPCRKAEG---NIMSPTLTGNNGVFSWSSCSRQYLKKFLSTPQAGCLVDEPKQAGQYKYPDKLP 511

  Fly   535 GMRYNARGQCRLQFNLTTDSEVGACSA--PHEFCSTLWC-KVNGECVTHMRPTAPGTLCGRNKWC 596
            |..|:|..||:.||.    ::...||.  ..:.|.:||| :|...|.|...|.|.||:||.:.||
Human   512 GQIYDADTQCKWQFG----AKAKLCSLGFVKDICKSLWCHRVGHRCETKFMPAAEGTVCGLSMWC 572

  Fly   597 QNGKCVRREELA--AVNGGWGDWSEWSECSRSCGGGVSTQQRECDNPVPANGGVFCIGERKRYKI 659
            :.|:||:..||.  .::|.|..||:||||||:|||||..|:|.|:||.|..||:||.|..:.|::
Human   573 RQGQCVKFGELGPRPIHGQWSAWSKWSECSRTCGGGVKFQERHCNNPKPQYGGLFCPGSSRIYQL 637

  Fly   660 CRKRPCPAEEPSFRAQQCARFDNVSYQGATYKWLPF--FDKNNPCKLFCSDVDDTIIANWGATVL 722
            |...||......|||||||.:::..::|..|:|.|:  .::.:.|||:|...:..........|.
Human   638 CNINPCNENSLDFRAQQCAEYNSKPFRGWFYQWKPYTKVEEEDRCKLYCKAENFEFFFAMSGKVK 702

  Fly   723 DGTPCTLGTNNMCIDGICKKVGCDWIVDSEVQDDRCGVCGGSGDQCQPVRETYTDPFAAKDGAYV 787
            |||||:...|::||||:|:.||||..:.|:...|.||||.|....|:..:..|.:...|.:  |.
Human   703 DGTPCSPNKNDVCIDGVCELVGCDHELGSKAVSDACGVCKGDNSTCKFYKGLYLNQHKANE--YY 765

  Fly   788 EIVTIPARARHILIRELANSPHFLAIATGDGGDRFYLNGDSLISMPGEFEIAGAESLYDR-VDEQ 851
            .:|.|||.||.|.|:||..|..:||:.:  ...::||.|...|..||||..||....|.| .:..
Human   766 PVVLIPAGARSIEIQELQVSSSYLAVRS--LSQKYYLTGGWSIDWPGEFPFAGTTFEYQRSFNRP 828

  Fly   852 ETITIPQPIQHSISLYAIVRGNESNAGIFYEFTLP-ALN----VTAGRQFQWRLSNWTACSASCG 911
            |.:..|.|...::....:::|  .|.||.:::.|| .:|    .|....:.|.:.. :.||.|||
Human   829 ERLYAPGPTNETLVFEILMQG--KNPGIAWKYALPKVMNGTPPATKRPAYTWSIVQ-SECSVSCG 890

  Fly   912 GGVQHREPICQENGKALGDTLPCWTHAKNKRPARQSRGCGDQPCPAHWWPGPWQFCPVTCRPVGF 976
            ||..:.:.||..:.....::..|  .||.| |..:.:.|....|||:|.||.|..|...|
Human   891 GGYINVKAICLRDQNTQVNSSFC--SAKTK-PVTEPKICNAFSCPAYWMPGEWSTCSKAC----- 947

  Fly   977 VAPPQRRRSVVCLD----EHDVVVADAECGHLQKPAEMEPCES 1015
             |..|:.|.:.|:.    :.:..|..:.| .:..|.:::.|.|
Human   948 -AGGQQSRKIQCVQKKPFQKEEAVLHSLC-PVSTPTQVQACNS 988

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AdamTS-B	NP_572247.2	Pep_M12B_propep	78..194	CDD:279848	40/123 (33%)
		ZnMc_ADAMTS_like	314..518	CDD:239801	89/208 (43%)
		Reprolysin	315..521	CDD:279729	91/210 (43%)
		ADAM_CR	<558..602	CDD:301627	18/46 (39%)
		TSP1	614..666	CDD:214559	28/51 (55%)
		ADAM_spacer1	773..886	CDD:283607	35/113 (31%)
		TSP1	901..956	CDD:214559	15/54 (28%)
ADAMTS18	NP_955387.1	Pep_M12B_propep	86..202	CDD:279848	40/124 (32%)
		Cysteine switch. /evidence=ECO:0000250	252..259		0/6 (0%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	258..291		9/36 (25%)
		ZnMc_ADAMTS_like	293..494	CDD:239801	88/208 (42%)
		Reprolysin	295..498	CDD:279729	91/210 (43%)
		TSP1	592..643	CDD:214559	27/50 (54%)
		ADAM_spacer1	749..861	CDD:283607	35/117 (30%)
		Spacer	750..876		39/131 (30%)
		TSP1	938..992	CDD:214559	13/58 (22%)
		TSP1	995..1049	CDD:214559
		TSP1	1059..1116	CDD:214559
		TSP1	1131..1178	CDD:214559
		PLAC	1188..1218	CDD:285849
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	71	1.000	Domainoid score	I9431
eggNOG	1	0.900	-	-		E1_KOG3538
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D125522at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm40606
orthoMCL	1	0.900	-	-		OOG6_100241
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.720