DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment AdamTS-B and ADAMTS14

DIOPT Version :9

Sequence 1:	NP_572247.2	Gene:	AdamTS-B / 31490	FlyBaseID:	FBgn0029791	Length:	1023	Species:	Drosophila melanogaster
Sequence 2:	NP_631894.2	Gene:	ADAMTS14 / 140766	HGNCID:	14899	Length:	1226	Species:	Homo sapiens

Alignment Length:	1123	Identity:	308/1123 - (27%)
Similarity:	439/1123 - (39%)	Gaps:	296/1123 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    38 SDELVAGEGQLVV------PRR----------VHPDGAFMTHQLEYAHELDHRRHRQRRSLNSEH 86
            |....|..|.:||      ||.          :||.|.....::        .||
Human    58 SGPAAASAGSMVVDTPPTLPRHSSHLRVARSPLHPGGTLWPGRV--------GRH---------- 104

  Fly    87 DTQAADLHLLLPLANETLHLELMAHSYFLAPNLVVERHRRDLRT--RSPLTTRHLNCHFHGKVRG 149
                 .|:..:.:..:.|||.|..:...:.|...|| .:.|.|.  |.||   ...|.:.|.|.|
Human   105 -----SLYFNVTVFGKELHLRLRPNRRLVVPGSSVE-WQEDFRELFRQPL---RQECVYTGGVTG 160

  Fly   150 QPATNVAISTCAGLVGHIRTAGNEYFIEP-SKEHEPHPVNGHPHVVFQRSSVKPKHSLRKRNKRK 213
            .|...||||.|.||.|.|||...::|||| .:..:....:|..|||::|.:|:.
Human   161 MPGAAVAISNCDGLAGLIRTDSTDFFIEPLERGQQEKEASGRTHVVYRREAVQQ----------- 214

  Fly   214 RGGKSGSGAEVSNCGTREPRRRMETRLEWQARGKVKVQGGRQIRRHHHHHHHHHHKHKYRHHQQK 278
                                       ||
Human   215 ---------------------------EW------------------------------------ 216

  Fly   279 ISRVPHTKFKYETQFQTEPD---HAE------IP---------------RRRRSISSPRHVETLI 319
                            .|||   |.|      :|               :||.:......:|.|:
Human   217 ----------------AEPDGDLHNEAFGLGDLPNLLGLVGDQLGDTERKRRHAKPGSYSIEVLL 265

  Fly   320 VADATMSAFH--RDLNGYLLTIMNMVSALYKDPSIGNSIEIVVVRIIQLDEEESQLQLNLTQNAQ 382
            |.|.::..||  ..:..|:||:||:|..:|.|.|:|..|.|.:||:|.:...:| |.|....|..
Human   266 VVDDSVVRFHGKEHVQNYVLTLMNIVDEIYHDESLGVHINIALVRLIMVGYRQS-LSLIERGNPS 329

  Fly   383 KNLDRFCSWQHKLNKGSEKDPHHHDVAILITRKNICANNCMTLGLANVGGMCKPKQSCSVNEDNG 447
            ::|::.|.|.|...:.......|||..:.:||::...:...  |.|.|.|||.|.:||::|.::|
Human   330 RSLEQVCRWAHSQQRQDPSHAEHHDHVVFLTRQDFGPSGMQ--GYAPVTGMCHPLRSCALNHEDG 392

  Fly   448 IMLSHTITHELGHNFGMFHDTAKIGCHPRVGPIVHIMTPTFGADTLQVCWSNCSRKYITHFLDQG 512
            ...:..|.||.||..||.||....||..... :..:|.|...|...:..||.||:..::.:|..
Human   393 FSSAFVIAHETGHVLGMEHDGQGNGCADETS-LGSVMAPLVQAAFHRFHWSRCSKLELSRYLPS- 455

  Fly   513 LGEC-LDDPPTPLDEYNYTGELPGMRYNARGQCRLQFNLTTDSEVGACSAPHEF--CSTLWCKVN 574
             .:| ||||..|  .:....||||:.|:...|||..|.    |....|.|...|  |..|||...
Human   456 -YDCLLDDPFDP--AWPQPPELPGINYSMDEQCRFDFG----SGYQTCLAFRTFEPCKQLWCSHP 513

  Fly   575 GE---CVTHMRPTAPGTLCGRNKWCQNGKCVRR--EELAAVNGGWGDWSEWSECSRSCGGGVSTQ 634
            ..   |.|...|...||.|...|||..|.|:.:  |:....:|||..|:::..|||||||||.::
Human   514 DNPYFCKTKKGPPLDGTECAPGKWCFKGHCIWKSPEQTYGQDGGWSSWTKFGSCSRSCGGGVRSR 578

  Fly   635 QRECDNPVPANGGVFCIGERKRYKICRKRPCPAEEPSFRAQQCARFDN-VSYQGATYKWLPF--F 696
            .|.|:||.||.||..|:|....|::|....||.....|||||||:.:: ..:|.|.:.|:|:  .
Human   579 SRSCNNPSPAYGGRLCLGPMFEYQVCNSEECPGTYEDFRAQQCAKRNSYYVHQNAKHSWVPYEPD 643

  Fly   697 DKNNPCKLFCSDVDDTIIANWGATVLDGTPCTL-GTNNMCIDGICKKVGCDWIVDSEVQDDRCGV 760
            |....|:|.|...|...:......|.|||.|:. ...::|..|.|..||||..|.|...||:|||
Human   644 DDAQKCELICQSADTGDVVFMNQVVHDGTRCSYRDPYSVCARGECVPVGCDKEVGSMKADDKCGV 708

  Fly   761 CGGSGDQCQPVRETYTDPFAAKDGAYVEIVTIPARARHILIRELANSPHFLAI---ATGDGGDRF 822
            |||....|:.|:.|...  |:|....:::|.|||.||||.|..|..|||.:.:   .||.    |
Human   709 CGGDNSHCRTVKGTLGK--ASKQAGALKLVQIPAGARHIQIEALEKSPHRIVVKNQVTGS----F 767

  Fly   823 YLNGDSLISMPGEFEIAGAESLYDRV-DEQETITIPQPIQHSISLYAI------VRGNESNAGIF 880
            .||.....:....|...|.| ..|.| |.:|::....|:..:|::.|:      .|.:.:...:.
Human   768 ILNPKGKEATSRTFTAMGLE-WEDAVEDAKESLKTSGPLPEAIAILALPPTEGGPRSSLAYKYVI 831

  Fly   881 YEFTLPAL---NVTAGRQ--FQWRLSNWTACSASCGGGVQHREPICQEN------GKALGDTLPC 934
            :|..||.:   ||.....  ::|.|.:|..||.:||||:|..:..|:..      .:.|.|
Human   832 HEDLLPLIGSNNVLLEEMDTYEWALKSWAPCSKACGGGIQFTKYGCRRRRDHHMVQRHLCD---- 892

  Fly   935 WTHAKNKRPARQ--------------------SRGC----------------------------- 950
              |.|..:|.|:                    ||.|
Human   893 --HKKRPKPIRRRCNQHPCSQPVWVTEEWGACSRSCGKLGVQTRGIQCLLPLSNGTHKVMPAKAC 955

  Fly   951 -GDQ----------PCPAHWWPGPWQFCPVTCRPVGFVAPPQRRRSVVCLDEHDVVVADAECGHL 1004
             ||:          ||||.|..|.|..|..||      ....::|.|||....:      ..||.
Human   956 AGDRPEARRPCLRVPCPAQWRLGAWSQCSATC------GEGIQQRQVVCRTNAN------SLGHC 1008

  Fly  1005 Q--KPAEMEPCESSLPIC 1020
            :  :|..::.|  |||.|
Human  1009 EGDRPDTVQVC--SLPAC 1024

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AdamTS-B	NP_572247.2	Pep_M12B_propep	78..194	CDD:279848	35/118 (30%)
		ZnMc_ADAMTS_like	314..518	CDD:239801	65/206 (32%)
		Reprolysin	315..521	CDD:279729	68/208 (33%)
		ADAM_CR	<558..602	CDD:301627	17/48 (35%)
		TSP1	614..666	CDD:214559	23/51 (45%)
		ADAM_spacer1	773..886	CDD:283607	33/122 (27%)
		TSP1	901..956	CDD:214559	21/120 (18%)
ADAMTS14	NP_631894.2	Pep_M12B_propep	104..206	CDD:279848	36/120 (30%)
		ZnMc_ADAMTS_like	273..460	CDD:239801	61/192 (32%)
		TSP1	558..610	CDD:214559	23/51 (45%)
		ADAM_spacer1	717..832	CDD:283607	33/121 (27%)
		Spacer	733..849		34/120 (28%)
		TSP1	913..972	CDD:214559	6/58 (10%)
		TSP1	978..1024	CDD:214559	16/59 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1103..1226
		DUF1180	1114..>1188	CDD:284165
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3538
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810