DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment AdamTS-B and Adamts1

DIOPT Version :9

Sequence 1:	NP_572247.2	Gene:	AdamTS-B / 31490	FlyBaseID:	FBgn0029791	Length:	1023	Species:	Drosophila melanogaster
Sequence 2:	NP_033751.3	Gene:	Adamts1 / 11504	MGIID:	109249	Length:	968	Species:	Mus musculus

Alignment Length:	1064	Identity:	346/1064 - (32%)
Similarity:	485/1064 - (45%)	Gaps:	218/1064 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 LLLHYWLVVVTQGGGVRPLYGLHSDELVAGEGQLVVPRRVHPDGAFMTHQLEYAHELDHRRHRQR 79
            ||....:::..:|...||   ...||      :||:|......|
Mouse    39 LLASITMLLCARGAHGRP---TEEDE------ELVLPSLERAPG--------------------- 73

  Fly    80 RSLNSEHDTQAADLHLLLPLANETLHLELMAHSYFLAPNLVVERHRRDLRT--RSP-LTTRHL-- 139
                  ||:...  .|.|....:.|||:|...|.||||...       |:|  ||| ...:||
Mouse    74 ------HDSTTT--RLRLDAFGQQLHLKLQPDSGFLAPGFT-------LQTVGRSPGSEAQHLDP 123

  Fly   140 -----NCHFHGKVRGQPATNVAISTCAGLVGHIRTAGNEYFIEPSKEHEPHPVNGH--PHVVFQR 197
                 :|.:.|.|.|.|.:..|:|.|.|:.|.....|.|:||:|:    |......  |.|..:.
Mouse   124 TGDLAHCFYSGTVNGDPGSAAALSLCEGVRGAFYLQGEEFFIQPA----PGVATERLAPAVPEEE 184

  Fly   198 SSVKPKHSLRKRNKRKRGGKSGSGAEVSNCG--------TREPR-RRMETRLEWQARGKVKVQGG 253
            ||.:|:..:.:|.:|..||        :.||        |.:.| ....||.:|..|.......|
Mouse   185 SSARPQFHILRRRRRGSGG--------AKCGVMDDETLPTSDSRPESQNTRNQWPVRDPTPQDAG 241

  Fly   254 RQIRRHHHHHHHHHHKHKYRHHQQKISRVPHTKFKYETQFQTEPDHAEIPRRRRSISSPRHVETL 318
            :                                          |......|::|.:||||:|||:
Mouse   242 K------------------------------------------PSGPGSIRKKRFVSSPRYVETM 264

  Fly   319 IVADATMSAFH-RDLNGYLLTIMNMVSALYKDPSIGNSIEIVVVRIIQLDEEESQLQLNLTQNAQ 382
            :|||.:|:.|| ..|..||||:.::.:..||.|||.|||.:|||:|:.:.||:...:  :|.||.
Mouse   265 LVADQSMADFHGSGLKHYLLTLFSVAARFYKHPSIRNSISLVVVKILVIYEEQKGPE--VTSNAA 327

  Fly   383 KNLDRFCSWQHKLNKGSEKDPHHHDVAILITRKNIC-ANNCMTLGLANVGGMCKPKQSCSVNEDN 446
            ..|..|||||.:.|..|::||.|:|.|||.||:::| ::.|.|||:|:||.:|.|.:||||.||:
Mouse   328 LTLRNFCSWQKQHNSPSDRDPEHYDTAILFTRQDLCGSHTCDTLGMADVGTVCDPSRSCSVIEDD 392

  Fly   447 GIMLSHTITHELGHNFGMFHDTAKIGCH----PRVGPIVHIMTPTFGADTLQVCWSNCSRKYITH 507
            |:..:.|..|||||.|.|.||.||   |    ..|....|:|.....:......||.||...:|.
Mouse   393 GLQAAFTTAHELGHVFNMPHDDAK---HCASLNGVSGDSHLMASMLSSLDHSQPWSPCSAYMVTS 454

  Fly   508 FLDQGLGECL-DDPPTPLDEYNYTGELPGMRYNARGQCRLQFNLTTDSEVGACSAPHEFCSTLWC 571
            |||.|.|||| |.|..|:   ....:|||..|:|..||:..|.    .|...|......|:||||
Mouse   455 FLDNGHGECLMDKPQNPI---KLPSDLPGTLYDANRQCQFTFG----EESKHCPDAASTCTTLWC 512

  Fly   572 K-VNG---ECVTHMRPTAPGTLCGRNKWCQNGKCVRREEL----AAVNGGWGDWSEWSECSRSCG 628
            . .:|   .|.|...|.|.||.||..|||.:||||.:.::    ..|:|.||.|..|.:|||:||
Mouse   513 TGTSGGLLVCQTKHFPWADGTSCGEGKWCVSGKCVNKTDMKHFATPVHGSWGPWGPWGDCSRTCG 577

  Fly   629 GGVSTQQRECDNPVPANGGVFCIGERKRYKICRKRPCPAEE-PSFRAQQCA---RFDNVSY-QGA 688
            |||....||||||||.|||.:|.|:|.||:.|....||... .:||.:||.   .|...|: ...
Mouse   578 GGVQYTMRECDNPVPKNGGKYCEGKRVRYRSCNIEDCPDNNGKTFREEQCEAHNEFSKASFGNEP 642

  Fly   689 TYKWLPFFDKNNP---CKLFCSDVDDTIIANWGATVLDGTPCTLGTNNMCIDGICKKVGCDWIVD 750
            |.:|.|.:...:|   |||.|..............|:|||||:..:.::|:.|.|.|.|||.|:|
Mouse   643 TVEWTPKYAGVSPKDRCKLTCEAKGIGYFFVLQPKVVDGTPCSPDSTSVCVQGQCVKAGCDRIID 707

  Fly   751 SEVQDDRCGVCGGSGDQCQPVR--ETYTDPFAAKDGAYVEIVTIPARARHILI-----RELANSP 808
            |:.:.|:||||||:|..|:.:.  .|.|.|      .|.:||||||.|.:|.:     |...|:.
Mouse   708 SKKKFDKCGVCGGNGSTCKKMSGIVTSTRP------GYHDIVTIPAGATNIEVKHRNQRGSRNNG 766

  Fly   809 HFLAIATGDGGDRFYLNGDSLISMPGE--------FEIAGAESLYDRVDEQETITIPQPIQ---- 861
            .||||...||  .:.|||:..:|...:        ...:|:.:..:|:.....:..|..||
Mouse   767 SFLAIRAADG--TYILNGNFTLSTLEQDLTYKGTVLRYSGSSAALERIRSFSPLKEPLTIQVLMV 829

  Fly   862 -HSIS-----LYAIVRGNES-NAGIFYEFTLPALNVTAGRQFQWRLSNWTACSASCGGGVQHREP 919
             |::.     .|.:.:..|| ||       :|..:       :|.:..|..||.:||.|.|.|..
Mouse   830 GHALRPKIKFTYFMKKKTESFNA-------IPTFS-------EWVIEEWGECSKTCGSGWQRRVV 880

  Fly   920 ICQE-NGKALGDTLPCWTHAKNKRPARQSRGCGDQPCPAHWWPGPWQFCPVTCRPVGFVAPPQRR 983
            .|:: ||.      |....||..:|| .:|.|.|.||| ||..|.|..|..||.. |:     ::
Mouse   881 QCRDINGH------PASECAKEVKPA-STRPCADLPCP-HWQVGDWSPCSKTCGK-GY-----KK 931

  Fly   984 RSVVCLDEHDVVVADAECGHLQKP 1007
            |::.|:.....|:::..|..|:||
Mouse   932 RTLKCVSHDGGVLSNESCDPLKKP 955

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AdamTS-B	NP_572247.2	Pep_M12B_propep	78..194	CDD:279848	37/127 (29%)
		ZnMc_ADAMTS_like	314..518	CDD:239801	94/210 (45%)
		Reprolysin	315..521	CDD:279729	95/212 (45%)
		ADAM_CR	<558..602	CDD:301627	20/47 (43%)
		TSP1	614..666	CDD:214559	29/51 (57%)
		ADAM_spacer1	773..886	CDD:283607	35/136 (26%)
		TSP1	901..956	CDD:214559	20/55 (36%)
Adamts1	NP_033751.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..23
		Pep_M12B_propep	70..194	CDD:279848	42/163 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	177..253		20/125 (16%)
		Cysteine switch. /evidence=ECO:0000250	204..211		2/6 (33%)
		Reprolysin	259..468	CDD:279729	96/213 (45%)
		ZnMc_ADAMTS_like	259..464	CDD:239801	93/209 (44%)
		ADAM_CR	469..549	CDD:301627	32/86 (37%)
		ADAM_CR	530..699	CDD:301627	68/168 (40%)
		TSP1	563..615	CDD:214559	29/51 (57%)
		Spacer	726..850		32/131 (24%)
		ADAM_spacer1	726..843	CDD:283607	31/124 (25%)
		TSP1	857..911	CDD:214559	21/67 (31%)
		TSP1	912..>954	CDD:214559	13/47 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3538
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S5862
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D125522at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100241
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.670