DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment AdamTS-B and ADAMTS6

DIOPT Version :9

Sequence 1:	NP_572247.2	Gene:	AdamTS-B / 31490	FlyBaseID:	FBgn0029791	Length:	1023	Species:	Drosophila melanogaster
Sequence 2:	NP_922932.2	Gene:	ADAMTS6 / 11174	HGNCID:	222	Length:	1117	Species:	Homo sapiens

Alignment Length:	1013	Identity:	356/1013 - (35%)
Similarity:	506/1013 - (49%)	Gaps:	143/1013 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    47 QLVVPRRVHPDGAFMTHQLEYAHELDHRRHRQRRSLNSEHDTQA-ADLHLLLPLANETLHLELMA 110
            ||.:|.||..:|||::..::     :.:..|:|||::.....|| :.|...|....:..||.|..
Human    43 QLTIPIRVDQNGAFLSFTVK-----NDKHSRRRRSMDPIDPQQAVSKLFFKLSAYGKHFHLNLTL 102

  Fly   111 HSYFLAPNLVVERHRRDLRTRSPLTTRHL--NCHFHGKVRGQ-PATNVAISTCAGLVGHIRTAGN 172
            ::.|::.:..||...:|    .|......  |||:.|.::.| ..|.||:|.|.||.|.|.|...
Human   103 NTDFVSKHFTVEYWGKD----GPQWKHDFLDNCHYTGYLQDQRSTTKVALSNCVGLHGVIATEDE 163

  Fly   173 EYFIEPSK---EHEPH--PVNGHPHVVFQRSSVKPKHSLRKRNKRKRGGKSGSGAEVSNCGTREP 232
            ||||||.|   |...|  ..||||||::::|:::.:|..                :.|:||..:.
Human   164 EYFIEPLKNTTEDSKHFSYENGHPHVIYKKSALQQRHLY----------------DHSHCGVSDF 212

  Fly   233 RRRMETRLEWQARGKVKVQGGRQIRRHHHHHHHHHHKHKYRHHQQKISRVPHTKFKYETQFQTEP 297
            .|   :...|.......|.....|...|.||
Human   213 TR---SGKPWWLNDTSTVSYSLPINNTHIHH---------------------------------- 240

  Fly   298 DHAEIPRRRRSISSPRHVETLIVADATMSAFH--RDLNGYLLTIMNMVSALYKDPSIGNSIEIVV 360
                  |::||:|..|.||||:|||..|..:|  :|:..|:|::||:|:.||:|.|:||.:.|:|
Human   241 ------RQKRSVSIERFVETLVVADKMMVGYHGRKDIEHYILSVMNIVAKLYRDSSLGNVVNIIV 299

  Fly   361 VRIIQLDEEESQLQLNLTQNAQKNLDRFCSWQHKL-------NKGSEKDPHHHDVAILITRKNIC 418
            .|:|.|.|::..|::|  .:|.|:||.||.||..:       |...|....|||.|:||||.:||
Human   300 ARLIVLTEDQPNLEIN--HHADKSLDSFCKWQKSILSHQSDGNTIPENGIAHHDNAVLITRYDIC 362

  Fly   419 A---NNCMTLGLANVGGMCKPKQSCSVNEDNGIMLSHTITHELGHNFGMFHDTAKIGCHPRVGPI 480
            .   ..|.|||||:|.|||:|::|||:|||.|:..:.||.||:||||||.||.....|..:....
Human   363 TYKNKPCGTLGLASVAGMCEPERSCSINEDIGLGSAFTIAHEIGHNFGMNHDGIGNSCGTKGHEA 427

  Fly   481 VHIMTPTFGADTLQVCWSNCSRKYITHFLDQGLGECLDDPPTPLDEYNYTGELPGMRYNARGQCR 545
            ..:|.....|:|....||.|||.|||.|||.|.|.|||:.| |..::.|....||..|:|..|||
Human   428 AKLMAAHITANTNPFSWSACSRDYITSFLDSGRGTCLDNEP-PKRDFLYPAVAPGQVYDADEQCR 491

  Fly   546 LQFNLTT-DSEVGACSAPHEFCSTLWC-KVNGECVTHMRPTAPGTLCGRNK----WCQNGKCVRR 604
            .|:..|: ..:.|      |.|..||| ..:..|||:..|.|.||||....    ||..|.||..
Human   492 FQYGATSRQCKYG------EVCRELWCLSKSNRCVTNSIPAAEGTLCQTGNIEKGWCYQGDCVPF 550

  Fly   605 EEL-AAVNGGWGDWSEWSECSRSCGGGVSTQQRECDNPVPANGGVFCIGERKRYKICRKRPCPAE 668
            ... .:::||||.||.|.||||:||||||:..|.||:|.|:.||.:|:||||||:.|...|||..
Human   551 GTWPQSIDGGWGPWSLWGECSRTCGGGVSSSLRHCDSPAPSGGGKYCLGERKRYRSCNTDPCPLG 615

  Fly   669 EPSFRAQQCARFDNVSYQGATYKWLPFFDKN-NPCKLFCSDVDDTIIANWGATVLDGTPCTLGTN 732
            ...||.:|||.|||:.::|..|.|.|:.... .||.|.|..............|:|||.|...:.
Human   616 SRDFREKQCADFDNMPFRGKYYNWKPYTGGGVKPCALNCLAEGYNFYTERAPAVIDGTQCNADSL 680

  Fly   733 NMCIDGICKKVGCDWIVDSEVQDDRCGVCGGSGDQCQPVRETYTDPFAAKDGAYVEIVTIPARAR 797
            ::||:|.||.||||.|:.|:.::|||.||||.|..|..:...:.|  :...|.|:|:|.||..:.
Human   681 DICINGECKHVGCDNILGSDAREDRCRVCGGDGSTCDAIEGFFND--SLPRGGYMEVVQIPRGSV 743

  Fly   798 HILIRELANSPHFLAIATGDGGDRFYLNGDSLISMPGEFEIAGAESLYDR-VDEQETITIPQPIQ 861
            ||.:||:|.|.:::|:.:  .||.:|:||...|..|.:|::||....|.| .||.|::....|..
Human   744 HIEVREVAMSKNYIALKS--EGDDYYINGAWTIDWPRKFDVAGTAFHYKRPTDEPESLEALGPTS 806

  Fly   862 HSISLYAIVRGNESNAGIFYEFTLPALNVTAGRQ---FQWRLSNWTACSASCGGGVQHREPICQE 923
            .::.:..:::  |.|.||.|:|.:|.....:|..   |.|....|:.|||:|.||||.:|.:|
Human   807 ENLIVMVLLQ--EQNLGIRYKFNVPITRTGSGDNEVGFTWNHQPWSECSATCAGGVQRQEVVC-- 867

  Fly   924 NGKALGDTLPCWTHAKN------KRPARQSRGCGDQPCPAHWWPGPWQFCPVTCRPVGFVAPPQR 982
              |.|.|.    :..:|      .:|....|.|..:|||..|:.|.|..|..||      ....|
Human   868 --KRLDDN----SIVQNNYCDPDSKPPENQRACNTEPCPPEWFIGDWLECSKTC------DGGMR 920

  Fly   983 RRSVVCL-----DEHDVVVADAECGHLQKPAEMEPCES 1015
            .|:|:|:     .|.:.:.......|  :|.|.|||.:
Human   921 TRAVLCIRKIGPSEEETLDYSGCLTH--RPVEKEPCNN 956

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AdamTS-B	NP_572247.2	Pep_M12B_propep	78..194	CDD:279848	44/124 (35%)
		ZnMc_ADAMTS_like	314..518	CDD:239801	97/215 (45%)
		Reprolysin	315..521	CDD:279729	99/217 (46%)
		ADAM_CR	<558..602	CDD:301627	17/48 (35%)
		TSP1	614..666	CDD:214559	31/51 (61%)
		ADAM_spacer1	773..886	CDD:283607	36/113 (32%)
		TSP1	901..956	CDD:214559	19/60 (32%)
ADAMTS6	NP_922932.2	Pep_M12B_propep	69..190	CDD:279848	44/124 (35%)
		Reprolysin	250..468	CDD:279729	100/219 (46%)
		ZnMc_ADAMTS_like	250..465	CDD:239801	98/216 (45%)
		TSP1	561..613	CDD:214559	31/51 (61%)
		Spacer	717..843		38/131 (29%)
		ADAM_spacer1	719..829	CDD:283607	36/115 (31%)
		TSP1	848..900	CDD:214559	19/59 (32%)
		TSP1	902..960	CDD:214559	17/63 (27%)
		TSP1	1022..1069	CDD:214559
		PLAC	1083..1115	CDD:285849
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	217	1.000	Domainoid score	I2674
eggNOG	1	0.900	-	-		E1_KOG3538
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D125522at2759
OrthoFinder	1	1.000	-	-		FOG0001196
OrthoInspector	1	1.000	-	-		otm40606
orthoMCL	1	0.900	-	-		OOG6_100241
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	8	7.720