DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment AdamTS-B and ADAMTS5

DIOPT Version :9

Sequence 1:	NP_572247.2	Gene:	AdamTS-B / 31490	FlyBaseID:	FBgn0029791	Length:	1023	Species:	Drosophila melanogaster
Sequence 2:	NP_008969.2	Gene:	ADAMTS5 / 11096	HGNCID:	221	Length:	930	Species:	Homo sapiens

Alignment Length:	881	Identity:	270/881 - (30%)
Similarity:	392/881 - (44%)	Gaps:	158/881 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   137 RH-LNCHFHGKVRGQPATNVAISTCAGLVGHIRTAGNEYFIEPSKEHEPHPVNGHPHVVFQRSSV 200
            || .:|.:.|.|.|.|.:......|.||.|........|.::|.       :.| |..
Human   125 RHRSHCFYRGTVDGSPRSLAVFDLCGGLDGFFAVKHARYTLKPL-------LRG-PWA------- 174

  Fly   201 KPKHSLRKRNKRKRGGKSGSG-AEVSNCGTRE--------PRRRMETRLEWQARGKVKVQGGRQI 256
                      :.::|...|.| |.:.:..|||        ||...||.....
Human   175 ----------EEEKGRVYGDGSARILHVYTREGFSFEALPPRASCETPASTP------------- 216

  Fly   257 RRHHHHHHHHHHKHKYRHHQQKISRVPHTKFKYETQFQTEPDHAEIP-----RRRRSISSPRHVE 316
            ..|.|...|.:...:.....|.:.           |....|.....|     |||||||..|.||
Human   217 EAHEHAPAHSNPSGRAALASQLLD-----------QSALSPAGGSGPQTWWRRRRRSISRARQVE 270

  Fly   317 TLIVADATMSAFH-RDLNGYLLTIMNMVSALYKDPSIGNSIEIVVVRIIQLDEEESQLQLNLTQN 380
            .|:||||:|:..: |.|..||||:.::.:.||...||.|.|.:.||:::.|.:::..|:  :::|
Human   271 LLLVADASMARLYGRGLQHYLLTLASIANRLYSHASIENHIRLAVVKVVVLGDKDKSLE--VSKN 333

  Fly   381 AQKNLDRFCSWQHKLNKGSEKDPHHHDVAILITRKNICA-NNCMTLGLANVGGMCKPKQSCSVNE 444
            |...|..||.|||:.|:..:....|:|.|||.||:::|. ::|.|||:|:||.:|.|::||:|.|
Human   334 AATTLKNFCKWQHQHNQLGDDHEEHYDAAILFTREDLCGHHSCDTLGMADVGTICSPERSCAVIE 398

  Fly   445 DNGIMLSHTITHELGHNFGMFHDTAKIGCHPRVGPI--VHIMTPTFGADTLQVCWSNCSRKYITH 507
            |:|:..:.|:.||:||..|:.||.:|. |....|..  ..:|:....:......||.|:...||.
Human   399 DDGLHAAFTVAHEIGHLLGLSHDDSKF-CEETFGSTEDKRLMSSILTSIDASKPWSKCTSATITE 462

  Fly   508 FLDQGLGECLDDPPTPLDEYNYTGELPGMRYNARGQCRLQFNLTTDSEVGACSAPHEFCSTLWCK 572
            |||.|.|.||.|  .|..:.....||||..|:|..||    |||...|...|.. .:.|:.|||.
Human   463 FLDDGHGNCLLD--LPRKQILGPEELPGQTYDATQQC----NLTFGPEYSVCPG-MDVCARLWCA 520

  Fly   573 V--NGE--CVTHMRPTAPGTLCGRNKWCQNGKCV----RREELAAVNGGWGDWSEWSECSRSCGG 629
            |  .|:  |:|...|...||.||:.:.|..||||    ::....:.:|.||.|..|.:|||||||
Human   521 VVRQGQMVCLTKKLPAVEGTPCGKGRICLQGKCVDKTKKKYYSTSSHGNWGSWGSWGQCSRSCGG 585

  Fly   630 GVSTQQRECDNPVPANGGVFCIGERKRYKICRKRPCPAEEPSFRAQQCARFDNVSYQG-----AT 689
            ||....|.|:||.|.|.|.:|.|:|..|:.|...|||....|||.:||...:  .||.     .|
Human   586 GVQFAYRHCNNPAPRNNGRYCTGKRAIYRSCSLMPCPPNGKSFRHEQCEAKN--GYQSDAKGVKT 648

  Fly   690 Y-KWLPFFDKNNP---CKLFCSDVDDTIIANWGATVLDGTPCTLGTNNMCIDGICKKVGCDWIVD 750
            : :|:|.:....|   |||.|..........:...|.|||.|.|.:|::|:.|.|.:.|||.|:.
Human   649 FVEWVPKYAGVLPADVCKLTCRAKGTGYYVVFSPKVTDGTECRLYSNSVCVRGKCVRTGCDGIIG 713

  Fly   751 SEVQDDRCGVCGGSGDQCQPVRETYTDPFAAKDGAYVEIVTIPARARHILIREL--ANSPHFLAI 813
            |::|.|:||||||....|..:..|    |..|...|.::|.||..|.||.:|:.  .:...|.|
Human   714 SKLQYDKCGVCGGDNSSCTKIVGT----FNKKSKGYTDVVRIPEGATHIKVRQFKAKDQTRFTA- 773

  Fly   814 ATGDGGDRFYL-----NGDSLISMPGEFEIAGAESLYDRVDEQETITIPQPIQH----------- 862
                     ||     ||:.||:  |::.|:.:|::   :|...|:.......|
Human   774 ---------YLALKKKNGEYLIN--GKYMISTSETI---IDINGTVMNYSGWSHRDDFLHGMGYS 824

  Fly   863 ---SISLYAIVRGNESN-AGIFYEFTLP------ALNVTA---------GRQFQWRLSNWTACSA 908
               .|.:..|:..:.:. ..:.|.|.:|      ..:||:         ..|.||....|.|||.
Human   825 ATKEILIVQILATDPTKPLDVRYSFFVPKKSTPKVNSVTSHGSNKVGSHTSQPQWVTGPWLACSR 889

  Fly   909 SCGGGVQHREPICQENGKALGDTLPCWTHAKNKRPA 944
            :|..|...|...||:..:.|....|.     ::||:
Human   890 TCDTGWHTRTVQCQDGNRKLAKGCPL-----SQRPS 920

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AdamTS-B	NP_572247.2	Pep_M12B_propep	78..194	CDD:279848	15/57 (26%)
		ZnMc_ADAMTS_like	314..518	CDD:239801	79/207 (38%)
		Reprolysin	315..521	CDD:279729	81/209 (39%)
		ADAM_CR	<558..602	CDD:301627	17/47 (36%)
		TSP1	614..666	CDD:214559	26/51 (51%)
		ADAM_spacer1	773..886	CDD:283607	29/134 (22%)
		TSP1	901..956	CDD:214559	13/44 (30%)
ADAMTS5	NP_008969.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	24..69
		Pep_M12B_propep	67..168	CDD:307618	12/42 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	206..231		6/37 (16%)
		Cysteine switch. /evidence=ECO:0000250	207..214		2/6 (33%)
		ZnMc_ADAMTS_like	269..473	CDD:239801	79/206 (38%)
		TSP1	570..622	CDD:214559	26/51 (51%)
		Spacer	732..874		32/160 (20%)
		ADAM_spacer1	732..852	CDD:310520	29/138 (21%)
		TSP1	879..930	CDD:214559	14/47 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3538
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D125522at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100241
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.720