DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment AdamTS-B and ADAMTS13

DIOPT Version :9

Sequence 1:	NP_572247.2	Gene:	AdamTS-B / 31490	FlyBaseID:	FBgn0029791	Length:	1023	Species:	Drosophila melanogaster
Sequence 2:	NP_620594.1	Gene:	ADAMTS13 / 11093	HGNCID:	1366	Length:	1427	Species:	Homo sapiens

Alignment Length:	805	Identity:	251/805 - (31%)
Similarity:	353/805 - (43%)	Gaps:	118/805 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   281 RVPHTKFKYETQFQTEPDHAEIPRRRRSISSPRHVETLI-VADATMSAFHRDLNGYLLTIMNMVS 344
            |.|...|:.:.|           |:||:.....|:|.|: |......|...|...|:||.:|:.:
Human    59 RPPSPGFQRQRQ-----------RQRRAAGGILHLELLVAVGPDVFQAHQEDTERYVLTNLNIGA 112

  Fly   345 ALYKDPSIGNSIEIVVVRIIQLDEEESQLQLNLTQNAQKNLDRFCSWQHKLNKGSEKDPHHHDVA 409
            .|.:|||:|....:.:|:::.|.|.|.  ..|:|.|...:|...|.|...:|...:.||.|.|:.
Human   113 ELLRDPSLGAQFRVHLVKMVILTEPEG--APNITANLTSSLLSVCGWSQTINPEDDTDPGHADLV 175

  Fly   410 ILITR--KNICANNCMTLGLANVGGMCKPKQSCSVNEDNGIMLSHTITHELGHNFGMFHDTAK-I 471
            :.|||  ..:...|....|:..:||.|.|..||.:.||.|..|..||.||:||:||:.||.|. .
Human   176 LYITRFDLELPDGNRQVRGVTQLGGACSPTWSCLITEDTGFDLGVTIAHEIGHSFGLEHDGAPGS 240

  Fly   472 GCHPRVGPIVHIMTPTFGADTLQVCWSNCSRKYITHFLDQGLGECLDDPPTPLDEYNYTGE---- 532
            ||    ||..|:|.....|....:.||.|||:.:...|..|...|:.|||.|  :....|.
Human   241 GC----GPSGHVMASDGAAPRAGLAWSPCSRRQLLSLLSAGRARCVWDPPRP--QPGSAGHPPDA 299

  Fly   533 LPGMRYNARGQCRLQFNLTTDSEVGACSAPHE---FCSTLWCKVN----GECVTHMRPTAPGTLC 590
            .||:.|:|..|||:.|.    .:..||:...|   .|..|.|..:    ..|...:.|...||.|
Human   300 QPGLYYSANEQCRVAFG----PKAVACTFAREHLDMCQALSCHTDPLDQSSCSRLLVPLLDGTEC 360

  Fly   591 GRNKWCQNGKC---VRREELAAVNGGWGDWSEWSECSRSCGGGVSTQQRECDNPVPANGGVFCIG 652
            |..|||..|:|   |....:|||:|.|..|...|.|||||||||.|::|:|:||.||.||..|:|
Human   361 GVEKWCSKGRCRSLVELTPIAAVHGRWSSWGPRSPCSRSCGGGVVTRRRQCNNPRPAFGGRACVG 425

  Fly   653 ERKRYKICRKRPCPAEEPSFRAQQCARFD----NVSYQGAT-YKW---LPFFDKNNPCKLFCSDV 709
            ...:.::|..:.|...:..|.:|||||.|    ..|..||: |.|   :|....:..|:..|..:
Human   426 ADLQAEMCNTQACEKTQLEFMSQQCARTDGQPLRSSPGGASFYHWGAAVPHSQGDALCRHMCRAI 490

  Fly   710 DDTIIANWGATVLDGTPCTL------GTNNMCIDGICKKVGCDWIVDSEVQDDRCGVCGGSGDQC 768
            .::.|...|.:.||||.|..      ||.::|:.|.|:..|||..:||:...|||.||||....|
Human   491 GESFIMKRGDSFLDGTRCMPSGPREDGTLSLCVSGSCRTFGCDGRMDSQQVWDRCQVCGGDNSTC 555

  Fly   769 QPVRETYTDPFAAKDGAYVEIVTIPARARHILIRELANSPHFLAIATGDGGDRFYLNGDSLIS-- 831
            .|.:.::|   |.:...||..:|:......:.|..  :.|.|..:|...|| |:.:.|...||
Human   556 SPRKGSFT---AGRAREYVTFLTVTPNLTSVYIAN--HRPLFTHLAVRIGG-RYVVAGKMSISPN 614

  Fly   832 --MPG-------EFEIAGAESLYDRVDEQETITIPQPIQHSISLYAIVRGNESNAGIFYEFTLPA 887
              .|.       |:.:|..|   ||:...|.|.|..|:|....:....|..|.    :...|.|.
Human   615 TTYPSLLEDGRVEYRVALTE---DRLPRLEEIRIWGPLQEDADIQVYRRYGEE----YGNLTRPD 672

  Fly   888 LNVTAGRQFQ------WRLSNWTA----CSASCGGGVQHREPICQENG-KALGDTLPCWTHAKNK 941
            :..|   .||      |   .|.|    ||.|||.|::.....|.:.. |.|.:|:.|   ..::
Human   673 ITFT---YFQPKPRQAW---VWAAVRGPCSVSCGAGLRWVNYSCLDQARKELVETVQC---QGSQ 728

  Fly   942 RPARQSRGCGDQPCPAHWWPGPWQFCPVTC------RPVGFV---------APPQRRRSVVCLDE 991
            :|......|..:|||.:|..|.:..|..:|      |||..|         .||.|.|:    ..
Human   729 QPPAWPEACVLEPCPPYWAVGDFGPCSASCGGGLRERPVRCVEAQGSLLKTLPPARCRA----GA 789

  Fly   992 HDVVVADAECGHLQKPAEMEPCESS 1016
            ....||...|.....||..|..|.|
Human   790 QQPAVALETCNPQPCPARWEVSEPS 814

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AdamTS-B	NP_572247.2	Pep_M12B_propep	78..194	CDD:279848
		ZnMc_ADAMTS_like	314..518	CDD:239801	71/207 (34%)
		Reprolysin	315..521	CDD:279729	71/209 (34%)
		ADAM_CR	<558..602	CDD:301627	17/53 (32%)
		TSP1	614..666	CDD:214559	24/51 (47%)
		ADAM_spacer1	773..886	CDD:283607	29/123 (24%)
		TSP1	901..956	CDD:214559	16/59 (27%)
ADAMTS13	NP_620594.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	51..70		3/10 (30%)
		ZnMc_ADAMTS_like	80..283	CDD:239801	71/208 (34%)
		TSP1	387..439	CDD:214559	24/51 (47%)
		Cysteine-rich	440..556		39/115 (34%)
		Cell attachment site. /evidence=ECO:0000255	498..500		0/1 (0%)
		Spacer	556..685		34/144 (24%)
		ADAM_spacer1	559..680	CDD:283607	32/136 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3538
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D125522at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR13723
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.920