DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment AdamTS-B and Adamts6

DIOPT Version :9

Sequence 1:	NP_572247.2	Gene:	AdamTS-B / 31490	FlyBaseID:	FBgn0029791	Length:	1023	Species:	Drosophila melanogaster
Sequence 2:	NP_001074489.1	Gene:	Adamts6 / 108154	MGIID:	1347348	Length:	1117	Species:	Mus musculus

Alignment Length:	1020	Identity:	352/1020 - (34%)
Similarity:	504/1020 - (49%)	Gaps:	157/1020 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    47 QLVVPRRVHPDGAFMTHQLEYAHELDHRRHRQRRSLNSEHDTQA-ADLHLLLPLANETLHLELMA 110
            ||.:|.||..:|||::..::     :.:..|:|||::.....|| :.|...|....:..||.|..
Mouse    43 QLTIPIRVDQNGAFLSFTVK-----NDKHSRRRRSMDLLDPQQAVSKLFFKLSAYGKHFHLNLTL 102

  Fly   111 HSYFLAPNLVVERHRRDLRTRSPLTTRHL--NCHFHGKVRGQ-PATNVAISTCAGLVGHIRTAGN 172
            ::.|::.:..||...:|    .|......  |||:.|.::.| ..|.||:|.|.||.|.|.|...
Mouse   103 NTNFVSKHFTVEYWGKD----GPQWKHDFLDNCHYTGYLQDQHSTTKVALSNCVGLHGIIATEDE 163

  Fly   173 EYFIEPSK---EHEPH--PVNGHPHVVFQRSSVKPKHSLRKRNKRKRGGKSGSGAEVSNCGTRE- 231
            ||||||.|   |...|  ..||||||::::|:::.:|..                :.|:||..:
Mouse   164 EYFIEPLKNTTEDSKHFSYENGHPHVIYKKSTLQQQHIY----------------DHSHCGVSDL 212

  Fly   232 -----PRRRMETRLEWQARGKVKVQGGRQIRRHHHHHHHHHHKHKYRHHQQKISRVPHTKFKYET 291
                 |         |.............|...|.||
Mouse   213 TGSGKP---------WWLNKTSSFPSLPPINDTHIHH---------------------------- 240

  Fly   292 QFQTEPDHAEIPRRRRSISSPRHVETLIVADATMSAFH--RDLNGYLLTIMNMVSALYKDPSIGN 354
                        |:|||:|:.|.||||:|||..|..:|  :|:..|:|::||:|:.||:|.|:||
Mouse   241 ------------RKRRSVSTERFVETLVVADKMMVGYHGRKDIEHYILSVMNIVAKLYRDSSLGN 293

  Fly   355 SIEIVVVRIIQLDEEESQLQLNLTQNAQKNLDRFCSWQHKL-------NKGSEKDPHHHDVAILI 412
            .:.|:|.|:|.|.|::..|::|  .:|.|:||.||.||..:       |...|....|||.|:||
Mouse   294 VVNIIVARLIVLTEDQPNLEIN--HHADKSLDSFCKWQKSILSHQSDGNTIPENGIAHHDNAVLI 356

  Fly   413 TRKNICA---NNCMTLGLANVGGMCKPKQSCSVNEDNGIMLSHTITHELGHNFGMFHDTAKIGCH 474
            ||.:||.   ..|.|||||:|.|||:|::|||:|||.|:..:.||.||:||||||.||.....|.
Mouse   357 TRYDICTYKNKPCGTLGLASVAGMCEPERSCSINEDIGLGSAFTIAHEIGHNFGMNHDGIGNSCG 421

  Fly   475 PRVGPIVHIMTPTFGADTLQVCWSNCSRKYITHFLDQGLGECLDDPPTPLDEYNYTGELPGMRYN 539
            .:......:|.....|:|....||.|||.|||.|||.|.|.|||:.| |..::.|....||..|:
Mouse   422 TKGHEAAKLMAAHITANTNPFSWSACSRDYITSFLDSGRGTCLDNEP-PKRDFLYPAVAPGQVYD 485

  Fly   540 ARGQCRLQFNLTT-DSEVGACSAPHEFCSTLWC-KVNGECVTHMRPTAPGTLCGRNK----WCQN 598
            |..|||.|:..|: ..:.|      |.|..||| ..:..|||:..|.|.||||....    ||..
Mouse   486 ADEQCRFQYGATSRQCKYG------EVCRELWCLSKSNRCVTNSIPAAEGTLCQTGNIEKGWCYQ 544

  Fly   599 GKCVRREEL-AAVNGGWGDWSEWSECSRSCGGGVSTQQRECDNPVPANGGVFCIGERKRYKICRK 662
            |.||..... .:::||||.||.|.||||:||||||:..|.||:|.|:.||.:|:||||||:.|..
Mouse   545 GDCVPFGTWPQSIDGGWGSWSLWGECSRTCGGGVSSSLRHCDSPAPSGGGKYCLGERKRYRSCNT 609

  Fly   663 RPCPAEEPSFRAQQCARFDNVSYQGATYKWLPFFDKN-NPCKLFCSDVDDTIIANWGATVLDGTP 726
            .|||.....||.:|||.||::.::|..|.|.|:.... .||.|.|..............|:|||.
Mouse   610 DPCPLGSRDFREKQCADFDSMPFRGKHYNWKPYTGGGVKPCALNCLAEGYNFYTERAPAVIDGTQ 674

  Fly   727 CTLGTNNMCIDGICKKVGCDWIVDSEVQDDRCGVCGGSGDQCQPVRETYTDPFAAKDGAYVEIVT 791
            |...:.::||:|.||.||||.|:.|:.::|||.||||.|..|..:...:.|  :...|.|:|:|.
Mouse   675 CNADSLDICINGECKHVGCDNILGSDAREDRCRVCGGDGSTCDAIEGFFND--SLPRGGYMEVVQ 737

  Fly   792 IPARARHILIRELANSPHFLAIATGDGGDRFYLNGDSLISMPGEFEIAGAESLYDR-VDEQETIT 855
            ||..:.||.:||::.|.:::|:.:  .||.:|:||...|..|.:|:::|....|.| .||.|::.
Mouse   738 IPRGSVHIEVREVSMSKNYIALKS--EGDDYYINGAWTIDWPRKFDVSGTAFHYKRPTDEPESLE 800

  Fly   856 IPQPIQHSISLYAIVRGNESNAGIFYEFTLPALNVTAGRQ---FQWRLSNWTACSASCGGGVQHR 917
            ...|...::.:..:::  |.|.||.|:|.:|.:...:|..   |.|....|..|||:|.||||.:
Mouse   801 ALGPTSENLIVMVLLQ--EQNLGIRYKFNVPIVRTGSGDNEVGFMWTYQPWAECSATCAGGVQRQ 863

  Fly   918 EPICQENGKALGDTLPCWTHAKN------KRPARQSRGCGDQPCPAHWWPGPWQFCPVTCRPVGF 976
            |.:|    |.|.|.    :..:|      .:|....|.|..:|||..|:.|.|..|..||
Mouse   864 EVVC----KRLDDN----SIVQNNFCDPDSKPPENQRACNTEPCPPEWFIGDWLECSKTC----- 915

  Fly   977 VAPPQRRRSVVCL------DEHDVVVADAECGHLQKPAEMEPCES 1015
             ....|.|:|:|:      :|..:...|.   ...:|.|.|.|.:
Mouse   916 -DGGMRTRAVLCIRKVGPSEEETLDYGDC---LTHRPVEKESCNN 956

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AdamTS-B	NP_572247.2	Pep_M12B_propep	78..194	CDD:279848	44/124 (35%)
		ZnMc_ADAMTS_like	314..518	CDD:239801	97/215 (45%)
		Reprolysin	315..521	CDD:279729	99/217 (46%)
		ADAM_CR	<558..602	CDD:301627	17/48 (35%)
		TSP1	614..666	CDD:214559	31/51 (61%)
		ADAM_spacer1	773..886	CDD:283607	34/113 (30%)
		TSP1	901..956	CDD:214559	19/60 (32%)
Adamts6	NP_001074489.1	Pep_M12B_propep	43..191	CDD:366707	54/156 (35%)
		ZnMc_ADAMTS_like	250..465	CDD:239801	98/216 (45%)
		ADAM_CR_2	480..548	CDD:375321	27/73 (37%)
		TSP1	561..613	CDD:214559	31/51 (61%)
		ADAM_spacer1	719..829	CDD:368694	34/115 (30%)
		TSP1	843..900	CDD:214559	20/64 (31%)
		TSP1	902..960	CDD:214559	16/64 (25%)
		TSP1	1022..1069	CDD:214559
		PLAC	1083..1115	CDD:370061
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	212	1.000	Domainoid score	I2766
eggNOG	1	0.900	-	-		E1_KOG3538
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D125522at2759
OrthoFinder	1	1.000	-	-		FOG0001196
OrthoInspector	1	1.000	-	-		otm42682
orthoMCL	1	0.900	-	-		OOG6_100241
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	6.720