DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment AdamTS-B and Adamts13

DIOPT Version :9

Sequence 1:	NP_572247.2	Gene:	AdamTS-B / 31490	FlyBaseID:	FBgn0029791	Length:	1023	Species:	Drosophila melanogaster
Sequence 2:	XP_006233941.3	Gene:	Adamts13 / 102554393	RGDID:	1311594	Length:	1482	Species:	Rattus norvegicus

Alignment Length:	785	Identity:	241/785 - (30%)
Similarity:	352/785 - (44%)	Gaps:	114/785 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   299 HAEIPRRRRSISSPRHVETLI-VADATMSAFHRDLNGYLLTIMNMVSALYKDPSIGNSIEIVVVR 362
            |.:..|:||:.....|:|.|: |......|...|...|:||.:|:.|.|.::||:|..:::.:|:
  Rat   125 HLQRLRQRRTSEDILHLELLVAVGPDVYQAHQEDTERYVLTNLNIGSELLRNPSLGAQLQVHLVK 189

  Fly   363 IIQLDEEESQLQLNLTQNAQKNLDRFCSWQHKLNKGSEKDPHHHDVAILITR--KNICANNCMTL 425
            :|.|.:.|:  ..|:|.|...:|...|.|...:|...::||.|.|:.|.|||  ..:...|....
  Rat   190 LIILSDSEN--TPNITTNITSSLMSVCEWSQTINPHDDRDPSHADLIIYITRFDLELPDGNQQVR 252

  Fly   426 GLANVGGMCKPKQSCSVNEDNGIMLSHTITHELGHNFGMFHDTAK---IGCHPRVGPIVHIM--- 484
            |:...||.|.|..||.:.||.|..|..||.||:||:||:.||.|.   ..|..|    .|:|
  Rat   253 GVTQQGGACSPSWSCLITEDTGFDLGVTIAHEIGHSFGLDHDGAPGSGSTCEAR----GHVMASD 313

  Fly   485 --TPTFGADTLQVCWSNCSRKYITHFLDQGLGECLDDPP---TPLDEYNYTGELPGMRYNARGQC 544
              .|..||    :.||.||::.:.|.|..|...||.|||   :.|..:....: ||:.|:|..||
  Rat   314 GAVPAGGA----LEWSTCSQRQLQHLLSTGQMHCLWDPPGLQSGLTWHQLVAQ-PGLFYSADDQC 373

  Fly   545 RLQFNLTTDSEVGACSAPHE---FCSTLWCKVN----GECVTHMRPTAPGTLCGRNKWCQNGKCV 602
            |:.|.    :...||:...|   .|..|.|..:    ..|...:.|...||.||..|||...:|.
  Rat   374 RVAFG----AGAVACTFSREGLDVCQALSCHTDPLDQSSCSRLLVPLLDGTECGVEKWCSKARCR 434

  Fly   603 RREEL---AAVNGGWGDWSEWSECSRSCGGGVSTQQRECDNPVPANGGVFCIGERKRYKICRKRP 664
            ...||   |.|:|.|..|...|.|||||||||.|::|.|:||.||.||..|:||..:.|:|..:.
  Rat   435 SLAELAPVAVVHGHWSSWGPHSPCSRSCGGGVITRRRWCNNPRPAFGGRACVGEDLQAKMCNTQA 499

  Fly   665 CPAEEPSFRAQQCARFDNVSYQ-----GATYKW---LPFFDKNNPCKLFCSDVDDTIIANWGATV 721
            |...:..|.::|||:.|....|     .:.|.|   :.:...:..|:..|..|.::.|.:.|.:.
  Rat   500 CEKTQLEFMSEQCAQTDRHPLQLSQGSASFYHWDAAVQYSQGDTLCRHMCWAVGESFIVSRGDSF 564

  Fly   722 LDGTPCTL------GTNNMCIDGICKKVGCDWIVDSEVQDDRCGVCGGSGDQCQPVRETYTDPFA 780
            ||||.|..      ||.::|:.|.|:..|||..:||:...|.|.||||....|.....::|   |
  Rat   565 LDGTRCVPNGPREDGTVSLCLLGSCRTFGCDGKMDSQQVWDACQVCGGDNSTCTSQNGSFT---A 626

  Fly   781 AKDGAYVE--IVTIPARARHILIRELANSPHFLAIATGDGGDRFYLNGDSLIS----MPG----- 834
            .:...||.  |||....:.|:    :.:.|.|..:|... .|.:.::|.|.:|    .|.
  Rat   627 GRAREYVTFLIVTPNMTSAHV----INHRPLFTHLAVRI-QDHYIVSGKSSMSPNVTYPSLLEDY 686

  Fly   835 --EFEIAGAESLYDRVDEQETITIPQPIQHSISLYAIVRGNESNAGIFYEFTLPALNVTAGRQFQ 897
              |:.:...|   |::...|.|.|..|::..|.:....|......|:    |.|.:..|..::.|
  Rat   687 RVEYRVTLTE---DQLPRLEEIHIRGPVRDDIEIQVYRRYGGEYGGL----THPDITFTYFQRKQ 744

  Fly   898 WRLSNWTA----CSASCGGGVQHREPICQE--------NGKALGDTLPCWTHAKNKRPARQSRGC 950
            .....|.|    ||.|||.|::.....||:        |.:..|...|         ||.| ..|
  Rat   745 QAAWVWAAKRGPCSVSCGAGLRWVTYSCQDQAQNKWVRNAQCQGSPQP---------PAWQ-EPC 799

  Fly   951 GDQPCPAHWWPGPWQFCPVTCRPVGFVAPPQRRRSVVCLDEHD---VVVADAECGHL-QKPA-EM 1010
            ...|||.||....:..|.|:|      ....|.||:.|::.|:   ..:..|.|..: |:|| |:
  Rat   800 VSAPCPPHWVADDFGPCSVSC------GGGLRERSLRCVEAHNGFLKTLPPAPCRAVAQQPAGEV 858

  Fly  1011 EPCES 1015
            |.|.|
  Rat   859 ENCNS 863

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AdamTS-B	NP_572247.2	Pep_M12B_propep	78..194	CDD:279848
		ZnMc_ADAMTS_like	314..518	CDD:239801	72/214 (34%)
		Reprolysin	315..521	CDD:279729	73/216 (34%)
		ADAM_CR	<558..602	CDD:301627	15/50 (30%)
		TSP1	614..666	CDD:214559	26/51 (51%)
		ADAM_spacer1	773..886	CDD:283607	27/125 (22%)
		TSP1	901..956	CDD:214559	18/66 (27%)
Adamts13	XP_006233941.3	ZnMc_ADAMTS_like	139..345	CDD:239801	72/215 (33%)
		ADAM_CR_2	363..433	CDD:407643	23/73 (32%)
		TSP1	449..501	CDD:214559	26/51 (51%)
		TSP1_ADAMTS	755..804	CDD:408800	15/58 (26%)
		TSP1_ADAMTS	808..866	CDD:408800	18/62 (29%)
		TSP1_ADAMTS	960..1014	CDD:408800
		TSP1_ADAMTS	1018..1074	CDD:408800
		TSP1_ADAMTS	1078..1134	CDD:408800
		TSP1_ADAMTS	1138..1192	CDD:408800
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D125522at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR13723
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	4.020