DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment AdamTS-B and adamtsl5

DIOPT Version :9

Sequence 1:	NP_572247.2	Gene:	AdamTS-B / 31490	FlyBaseID:	FBgn0029791	Length:	1023	Species:	Drosophila melanogaster
Sequence 2:	XP_005166548.1	Gene:	adamtsl5 / 101886605	ZFINID:	ZDB-GENE-161017-76	Length:	538	Species:	Danio rerio

Alignment Length:	304	Identity:	112/304 - (36%)
Similarity:	154/304 - (50%)	Gaps:	36/304 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly   603 RREELAAVNGG--------------WGDWSEWSECSRSCGGGVSTQQREC--DNPVPANGGVFCI 651
            ||.||    ||              |..|..||.||||||||.|.:.|.|  .|.|   ||. |.
Zfish    34 RRVEL----GGEGLQMRSQMHFMNEWASWGGWSVCSRSCGGGASVRTRTCMTRNLV---GGP-CP 90

  Fly   652 GERKRYKICRKRPCPAEEPSFRAQQCARF-DNVSYQGATYKWLPFFDKNNPCKLFCSDVDDTIIA 715
            |:.::||||..:.|||:...||..||..| |.....|:::.|..|...::||:|.|..:......
Zfish    91 GDTRQYKICNSKECPADSMDFRELQCKAFNDRPLVAGSSFHWTTFHGGSDPCELSCLAIGHNFYY 155

  Fly   716 NWGATVLDGTPCTLGTNNMCIDGICKKVGCDWIVDSEVQDDRCGVCGGSGDQCQPVRETYTDPFA 780
            |:| .|||||||......:|::|.|.|.|||.|..|:.|:|.|.||||....|...|..|... .
Zfish   156 NFG-RVLDGTPCQSDQGTVCVNGKCLKPGCDLIFGSQQQEDACMVCGGHNSTCLHHRSVYQSN-G 218

  Fly   781 AKDG--AYVEIVTIPARARHILIRELANSPHFLAIATGDGGDRFYLNGDSLISMPGEFEIAGAES 843
            ..:|  .|.|:..|||.|.||.:.:  ||.::||:.  :|..:|.:||:..|::|||:.:||.:.
Zfish   219 QNNGLFGYSEVTMIPAGATHIRVTD--NSRNYLALQ--NGHSQFVINGNWKINVPGEYSVAGTKL 279

  Fly   844 LYDR-VDEQETITIPQPIQHSISLYAIVRGNESNAGIFYEFTLP 886
            .|.| .|..|:..:..|.|.  .|:.:|...:..:||.||:.||
Zfish   280 QYRRSADTWESFEVSGPTQE--DLHIMVLSTDKKSGIEYEYWLP 321

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AdamTS-B	NP_572247.2	Pep_M12B_propep	78..194	CDD:279848
		ZnMc_ADAMTS_like	314..518	CDD:239801
		Reprolysin	315..521	CDD:279729
		ADAM_CR	<558..602	CDD:301627
		TSP1	614..666	CDD:214559	25/53 (47%)
		ADAM_spacer1	773..886	CDD:283607	36/115 (31%)
		TSP1	901..956	CDD:214559
adamtsl5	XP_005166548.1	TSP1	55..105	CDD:214559	25/53 (47%)
		ADAM_spacer1	219..321	CDD:283607	35/107 (33%)
		NTR	426..519	CDD:280015
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3538
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810