DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment AdamTS-B and Adamts9

DIOPT Version :9

Sequence 1:	NP_572247.2	Gene:	AdamTS-B / 31490	FlyBaseID:	FBgn0029791	Length:	1023	Species:	Drosophila melanogaster
Sequence 2:	NP_780523.3	Gene:	Adamts9 / 101401	MGIID:	1916320	Length:	1931	Species:	Mus musculus

Alignment Length:	1174	Identity:	336/1174 - (28%)
Similarity:	486/1174 - (41%)	Gaps:	310/1174 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    45 EGQLVVPRRVHPDGAFMTHQLEYAHELDHRRHRQRRSLNSEHD-----------TQAADLHLLLP 98
            |.::..|.||:|.|......:.:        .|:|||:||..|           :.::..|..|.
Mouse    47 EYEIASPIRVNPLGEPFPTNVHF--------KRRRRSINSASDPWPAFASSSSSSTSSQEHYRLS 103

  Fly    99 LANETLHLELMAHSYFLAPNLVVER------HRRDLRTRSPLTTRHLNCHFHGKVRGQPATNVAI 157
            ...:.....|.||:.|:||...|..      ::..|.:...:..||  |.:.|.|..:......|
Mouse   104 AFGQQFLFNLTAHTGFIAPLFTVTLLGEPGVNQTKLYSEEEMELRH--CFYKGHVNTKSEHTAVI 166

  Fly   158 STCAGLVGHIRTAGNEYFIEPSK---EHEPHPVNGHPHVVFQRSS-------------------- 199
            |.|:|::|..|:...:|||||.:   |.|.......||::::.|:
Mouse   167 SLCSGMMGTFRSHDGDYFIEPLQSVDEQEDEEEQNKPHIIYRHSTPQREPSTGKHACATSELKNS 231

  Fly   200 -VKPKHSLRKRNKRKRGG--------KSGSGAEVSNCGTREPRRRMETRLEWQARGKVKVQGGRQ 255
             .|.|..:|.|.:|||..        |||...:|.:..:.:..   .||..|
Mouse   232 HSKDKRKIRMRKRRKRNSLADDVALLKSGLATKVLSGYSNQTN---STRDRW------------- 280

  Fly   256 IRRHHHHHHHHHHKHKYRHHQQKISRVPHTKFKYETQFQTEPDHAEIPRRRRSISSPRHVETLIV 320
                       :||                                  |.:|.:|.||.||.::|
Mouse   281 -----------NHK----------------------------------RTKRFLSYPRFVEVMVV 300

  Fly   321 ADATMSAFH-RDLNGYLLTIMNMVSALYKDPSIGNSIEIVVVRIIQLDEEESQLQLNLTQNAQKN 384
            ||..|..:| .:|..|:||:|::|:::|||.||||.|.||:|.::.:..|:....:|.  |||..
Mouse   301 ADHRMVLYHGANLQHYILTLMSIVASIYKDSSIGNLINIVIVNLVVIHNEQEGPYINF--NAQTT 363

  Fly   385 LDRFCSWQHKLN--KGSEKDPHHHDVAILITRKNIC--ANNCMTLGLANVGGMCKPKQSCSVNED 445
            |..||.|||..|  .|.:     ||.|:|:||::||  .:.|.|||||.:|.:|.|.:|||::||
Mouse   364 LKNFCQWQHSKNYLGGIQ-----HDTAVLVTREDICRAQDKCDTLGLAELGTICDPYRSCSISED 423

  Fly   446 NGIMLSHTITHELGHNFGMFHDTAKIGCHPRVGPIVHIMTPTFGADTLQVCWSNCSRKYITHFLD 510
            :|:..:.||.|||||.|.|.||.:.......|....|:|.||....|....||.|||||||.|||
Mouse   424 SGLSTAFTIAHELGHVFNMPHDDSNKCKEEGVKSPQHVMAPTLNFYTNPWMWSKCSRKYITEFLD 488

  Fly   511 QGLGECLDDPPTPLDEYNYTGELPGMRYNARGQCRLQFNLTTDSEVGACSAPHEF-CSTLWC-KV 573
            .|.||||.:.|.. ..|....:|||:.||...||.|.|.      .|:...|:.. |..||| .|
Mouse   489 TGYGECLLNEPAS-RTYPLPSQLPGLLYNVNKQCELIFG------PGSQVCPYMMQCRRLWCNNV 546

  Fly   574 NGE---CVTHMRPTAPGTLCGRNKWCQNGKCVRRE-ELAAVNGGWGDWSEWSECSRSCGGGVSTQ 634
            :|.   |.|...|.|.||.|...|.|:.|.||.:| |..|::|.||.||.:..|||:||||:.|.
Mouse   547 DGAHKGCRTQHTPWADGTECEPGKHCKFGFCVPKEMEGPAIDGSWGGWSHFGTCSRTCGGGIKTA 611

  Fly   635 QRECDNPVPANGGVFCIGERKRYKICRKRPCPAEEPSFRAQQCARFD----NVSYQGATYKWLPF 695
            .|||:.|.|.|||.:|:|.|.::|.|...||..::..||.:|||.||    |::....:.:|:|.
Mouse   612 IRECNRPEPKNGGKYCVGRRMKFKSCNTEPCMKQKRDFREEQCAHFDGKHFNINGLLPSVRWVPK 676

  Fly   696 FD---KNNPCKLFCSDVDDTIIANWGATVLDGTPCTLGTNNMCIDGICKKVGCDWIVDSEVQDDR 757
            :.   ..:.|||||....:|........|:|||||...||::|:.|:|::.|||.|::|:.:.|:
Mouse   677 YSGILMKDRCKLFCRVAGNTAYYQLRDRVIDGTPCGQDTNDICVQGLCRQAGCDHILNSKARKDK 741

  Fly   758 CGVCGGSGDQCQPVRETYTDPFAAKDGAYVEIVTIPARARHILIRE-----LANSPHFLAIATGD 817
            ||:|||....|:.|..|    |......|..:|.|||.|..|.:|:     .:...::||::...
Mouse   742 CGICGGDNSSCKTVAGT----FNTVHYGYNTVVRIPAGATSIDVRQHSFSGKSEDDNYLALSNSK 802

  Fly   818 GGDRFYLNGDSLISM--------PGEFEIAGAESLYDRVDEQETITIPQPIQHSISLYAIVRGNE 874
            |  .|.||||.::||        ....|.:|::::.:|      :.....|:..:.|..:..|..
Mouse   803 G--EFLLNGDFVVSMSKREVRVGSAVIEYSGSDNVVER------LNCTDRIEEELLLQVLSVGKL 859

  Fly   875 SNAGIFYEFTLP----------------------------------------------------- 886
            .|..:.|.|.:|
Mouse   860 YNPDVRYSFNIPIEDKPQQFYWNSHGPWQACSKPCQGERRRKLVCTRESDQLTVSDQRCDRLPQP 924

  Fly   887 --------------------------------ALNVTAGRQFQ---------------------- 897
                                            .|::...:..:
Mouse   925 GPVTEACGTDCDLRWHVASKSECSAQCGLGYRTLDIHCAKYSRMDGKTEKVDDSFCSSQPRPSNQ 989

  Fly   898 -----------WRLSNWTACSASCGGGVQHREPICQENGKALGDTLPCWTHAKNKRPARQSRGCG 951
                       ||.|.||.||.||.||.|.|..||......:.|...| ||  .::...||  |.
Mouse   990 EKCSGECSTGGWRYSAWTECSRSCDGGTQRRRAICVNTRNDVLDDSKC-TH--QEKVVVQS--CN 1049

  Fly   952 DQPCPAHWWPGPWQFCPVTCRPVGFVAPPQRRRSVVCLDEHDVVVADAECGHLQKPAEMEPCESS 1016
            :..|| ||..|.|..|.|||      ....:.|.|.|....| .::|..|....||..|:.|:.
Mouse  1050 EFSCP-HWKTGDWSECLVTC------GKGHKHRQVWCQFGED-RLSDRMCDPEAKPEPMQTCQQ- 1105

  Fly  1017 LPIC 1020
             |.|
Mouse  1106 -PEC 1108

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AdamTS-B	NP_572247.2	Pep_M12B_propep	78..194	CDD:279848	36/135 (27%)
		ZnMc_ADAMTS_like	314..518	CDD:239801	93/208 (45%)
		Reprolysin	315..521	CDD:279729	94/210 (45%)
		ADAM_CR	<558..602	CDD:301627	17/48 (35%)
		TSP1	614..666	CDD:214559	26/51 (51%)
		ADAM_spacer1	773..886	CDD:283607	29/125 (23%)
		TSP1	901..956	CDD:214559	20/54 (37%)
Adamts9	NP_780523.3	Pep_M12B_propep	49..207	CDD:334593	42/167 (25%)
		ZnMc_ADAMTS_like	293..496	CDD:239801	94/209 (45%)
		TSP1	591..642	CDD:214559	25/50 (50%)
		ADAM_spacer1	753..871	CDD:310520	30/129 (23%)
		TSP1	1001..1054	CDD:214559	22/57 (39%)
		TSP1	1055..1108	CDD:214559	19/61 (31%)
		TSP1	1114..1166	CDD:214559
		TSP1	1186..1239	CDD:214559
		TSP1	1239..1296	CDD:214559
		TSP1	1328..1380	CDD:214559
		TSP1	1382..1436	CDD:214559
		TSP1	1441..1483	CDD:214559
		TSP1	1500..1551	CDD:214559
		TSP1	1560..1609	CDD:214559
		TSP1	1611..>1636	CDD:214559
		GON	1734..1930	CDD:337156
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3538
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D125522at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100241
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.720