DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment AdamTS-B and adamtsl3

DIOPT Version :9

Sequence 1:	NP_572247.2	Gene:	AdamTS-B / 31490	FlyBaseID:	FBgn0029791	Length:	1023	Species:	Drosophila melanogaster
Sequence 2:	XP_003198947.4	Gene:	adamtsl3 / 100534944	ZFINID:	ZDB-GENE-121030-8	Length:	1760	Species:	Danio rerio

Alignment Length:	450	Identity:	133/450 - (29%)
Similarity:	205/450 - (45%)	Gaps:	67/450 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   597 QNGKCVRREELAAVNGGWGDWSEWSECSRSCGGGVSTQQRECDNPVPANGGVFCIGERKRYKICR 661
            |:.:..|.:|  ..:.||..|..||:|||:||||.|...|.|     .||| .|.|...||:.|.
Zfish    63 QSSRTTRSDE--ERDTGWDAWGTWSDCSRTCGGGASYSLRRC-----LNGG-NCEGRNIRYRTCS 119

  Fly   662 KRPCPAEEPSFRAQQCARFDNVSYQGATYKWLPF-FDKNNPCKLFCSDVDDTIIANWGATVLDGT 725
            ...||.|...||||||:..:::.|||.||:|:|. :|..:||.|.|.......:......|||||
Zfish   120 NTDCPLESGDFRAQQCSAHNDIKYQGQTYEWIPVTYDPVSPCALRCQARGKGQVVELAPKVLDGT 184

  Fly   726 PCTLGTNNMCIDGICKKVGCDWIVDSEVQDDRCGVCGGSGDQCQPVRETYTDPFAAKDGAYVEIV 790
            .|...:.:|||.|||::||||..:.|..::|.||||.|.|..|:.:|.... |..:.:.....::
Zfish   185 RCKADSLDMCISGICQEVGCDRQLGSNAKEDNCGVCAGDGSTCRLIRGQAL-PHVSPEEPIKTVI 248

  Fly   791 TIPARARHILIRELANSPHFLAI-ATGDGGDRFYLNGDSLISMPGEFEIAGAESL------YDRV 848
            .:|..:|.  :|..|..|..:.| |.|....|..::          |..:|:.||      :.|.
Zfish   249 EVPMGSRG--LRITAKGPDMIVIEAHGQNSRREEVH----------FSSSGSHSLGNNTVEFQRG 301

  Fly   849 DEQETITIPQPIQHSISLYAIVRGNESNAGIFYEFTLPALNVTAGRQFQWRLSNWTACSASCGGG 913
            .|::|:....|:....::.....|.:... |.:.|..|.       ::|||.:::..||.:||||
Zfish   302 AERQTLRCYGPLTADFTVKVKYAGPKDTV-IQFMFYQPI-------RYQWRETDFFPCSVTCGGG 358

  Fly   914 VQHREPICQE--NGKALGDTLPCWTHAKNKRPARQSRGCGDQPCP-----------------AHW 959
            .|.....|.:  ..:::.:.| |.:..:|.:|..:.:.|..:|||                 ..|
Zfish   359 YQLNSADCVDIRYNRSVAEHL-CHSFPENTKPTPKLKECNMEPCPESDGFKEVMPYDHFQPLPRW 422

  Fly   960 WPGPWQFCPVTCRPVGFVAPPQRRRSVVCLDE--HD--VVVADAECGHLQKPAEMEPCES 1015
            ...||..|.|:|      ....:.||:||::|  |.  |.|.|.:|.|..:|...:.|.:
Zfish   423 EQNPWTSCSVSC------GGGSQERSIVCVEEDVHGQIVQVEDWKCTHSPRPISKQNCNT 476

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AdamTS-B	NP_572247.2	Pep_M12B_propep	78..194	CDD:279848
		ZnMc_ADAMTS_like	314..518	CDD:239801
		Reprolysin	315..521	CDD:279729
		ADAM_CR	<558..602	CDD:301627	1/4 (25%)
		TSP1	614..666	CDD:214559	22/51 (43%)
		ADAM_spacer1	773..886	CDD:283607	21/119 (18%)
		TSP1	901..956	CDD:214559	14/56 (25%)
adamtsl3	XP_003198947.4	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3538
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810