DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment AdamTS-B and adamts6

DIOPT Version :9

Sequence 1:	NP_572247.2	Gene:	AdamTS-B / 31490	FlyBaseID:	FBgn0029791	Length:	1023	Species:	Drosophila melanogaster
Sequence 2:	XP_002934253.2	Gene:	adamts6 / 100490362	XenbaseID:	XB-GENE-951750	Length:	1118	Species:	Xenopus tropicalis

Alignment Length:	1029	Identity:	349/1029 - (33%)
Similarity:	501/1029 - (48%)	Gaps:	174/1029 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    47 QLVVPRRVHPDGAFMTHQLEYAHELDHRRHRQRRSLN-SEHDTQAADLHLLLPLANETLHLELMA 110
            ||.||.||..:|||::..:.....|     |:|||:: .:.|..|:.|...:....:..||.|..
Frog    43 QLTVPIRVDHNGAFVSFTVNSDKHL-----RRRRSVDPRDQDQDASKLFFKISAYGKHFHLNLTL 102

  Fly   111 HSYFLAPNLVVERHRRDLRTRSPLTTRHL--NCHFHGKVRGQ-PATNVAISTCAGLVGHIRTAGN 172
            ::..::.:..||...::    .|......  |||:.|.::.| ..|.||:|.|.||.|.|.|...
Frog   103 NTDLVSKHFTVEYWGKN----GPEWKHDFIDNCHYTGYLQDQNTTTKVALSNCNGLHGVIATEDE 163

  Fly   173 EYFIEP------SKEHEPHPVNGHPHVVFQRSSVKPKHSLRKRNKRKRGGKSGSGAEVSNCGTRE 231
            ||||||      :.:|..|.: |||||::::|::
Frog   164 EYFIEPLDNVTENSKHYSHEM-GHPHVIYRKSAI------------------------------- 196

  Fly   232 PRRRMETRLEWQARGKVKVQGGRQIRRHHHHHHHHHHKHKYRHHQQKISRVPHTKFK-------- 288
                                               ||:|.        |..||...|
Frog   197 -----------------------------------HHRHS--------SNQPHCGVKDFTGNSKP 218

  Fly   289 --YETQFQTEP-----DHAEIPRR-RRSISSPRHVETLIVADATMSAFH--RDLNGYLLTIMNMV 343
              |..:|.|.|     |....||| |||:|..|.||||:|||..|..:|  :|:..|:|::||:|
Frog   219 WWYNHKFSTPPVPSDNDTENGPRRQRRSVSIERFVETLVVADKMMVGYHGRKDIEHYILSVMNIV 283

  Fly   344 SALYKDPSIGNSIEIVVVRIIQLDEEESQLQLNLTQNAQKNLDRFCSWQHKL-------NKGSEK 401
            :.||:|.|:||.:.|:|.|:|.|.|::..|::|  .:|.|:||.||.||..:       |...|.
Frog   284 AKLYRDSSLGNVVNIIVTRLIVLTEDQPNLEIN--HHADKSLDSFCKWQKSILSHQSDGNTIPEN 346

  Fly   402 DPHHHDVAILITRKNICA---NNCMTLGLANVGGMCKPKQSCSVNEDNGIMLSHTITHELGHNFG 463
            ...|||.|:||||.:||.   ..|.|||||:|.|||:|::|||:|||.|:..:.||.||:|||||
Frog   347 GIAHHDNAVLITRYDICTYKNKPCGTLGLASVAGMCEPERSCSINEDIGLGSAFTIAHEIGHNFG 411

  Fly   464 MFHDTAKIGCHPRVGPIVHIMTPTFGADTLQVCWSNCSRKYITHFLDQGLGECLDDPPTPLDEYN 528
            |.||.....|..:......:|.....::|....||.|||.|||.|||.|.|.|||:.| |..::.
Frog   412 MNHDGIGNSCGTKGHEAAKLMAAHITSNTNPFSWSACSRDYITSFLDSGRGTCLDNEP-PKRDFV 475

  Fly   529 YTGELPGMRYNARGQCRLQFNLTT-DSEVGACSAPHEFCSTLWC-KVNGECVTHMRPTAPGTLCG 591
            |....||..|:|..|||.|:..|: ..:.|      |.|..||| ..:..|||:..|.|.||||.
Frog   476 YPAVAPGQVYDADEQCRFQYGATSRQCKYG------EVCRELWCLSKSNRCVTNSIPAAEGTLCQ 534

  Fly   592 RNK----WCQNGKCVRREEL-AAVNGGWGDWSEWSECSRSCGGGVSTQQRECDNPVPANGGVFCI 651
            ...    ||..|.||..... .:::|.||.||.|.||:|:||||||:..|.||:|.|:.||.:|:
Frog   535 TGSIEKGWCYQGDCVPFGTWPKSIDGDWGPWSVWGECTRTCGGGVSSSIRHCDSPAPSGGGKYCL 599

  Fly   652 GERKRYKICRKRPCPAEEPSFRAQQCARFDNVSYQGATYKWLPFFDKN-NPCKLFCSDVDDTIIA 715
            ||||||:.|...|||:....||.:|||.|||:.::|..|.|.|:.... ..|.|.|.........
Frog   600 GERKRYRSCNTDPCPSGSRDFREKQCADFDNMPFRGKYYNWKPYTGGGVKACALNCLAEGYNFYT 664

  Fly   716 NWGATVLDGTPCTLGTNNMCIDGICKKVGCDWIVDSEVQDDRCGVCGGSGDQCQPVRETYTDPFA 780
            .....|:|||.|...:.::||:|.||.||||.|:.|:.::|||.||||.|..|:.:...:.|  :
Frog   665 ERAPAVIDGTRCNADSLDICINGECKHVGCDNILGSDAKEDRCRVCGGDGSTCEAIEGFFND--S 727

  Fly   781 AKDGAYVEIVTIPARARHILIRELANSPHFLAIATGDGGDRFYLNGDSLISMPGEFEIAGAESLY 845
            ...|.|:|:|.||..:.||.|:|::.|.:::|:.:  .||.:::||...|..|.:|::||....|
Frog   728 LPRGGYMEVVQIPRGSVHIEIKEVSVSKNYIALKS--EGDDYFINGAWTIDWPRKFDVAGTAFHY 790

  Fly   846 DR-VDEQETITIPQPIQHSISLYAIVRGNESNAGIFYEFTLPALNVTAGRQ---FQWRLSNWTAC 906
            .| .||.|::....|...|:.:..:::  |.|.||.|:|.:|.....:|..   |.|....|:.|
Frog   791 KRPTDEPESLEALGPTTESLIVMILLQ--EQNMGIRYKFNVPITRTGSGDNEVGFSWHHLPWSEC 853

  Fly   907 SASCGGGVQHREPICQENGKALGDTLPCWTHAKN------KRPARQSRGCGDQPCPAHWWPGPWQ 965
            ||:|.||:|.:|.:|    |.|.|.    :..:|      .:|....|.|..:.||..|:.|.|.
Frog   854 SATCAGGIQKQEVVC----KRLDDN----SVVQNNYCDLDSKPPETQRACNTELCPPEWFIGDWS 910

  Fly   966 FCPVTCRPVGFVAPPQRRRSVVCL----DEHDVVVADAECGHLQKPAEMEPCES 1015
            .|..||      ....|.|:|:|:    ...:..:.|..| ...:|.|.|.|.:
Frog   911 ECSKTC------DGGMRSRTVLCIRRIGPSEEETLDDISC-LTHRPIEKEACNN 957

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AdamTS-B	NP_572247.2	Pep_M12B_propep	78..194	CDD:279848	39/125 (31%)
		ZnMc_ADAMTS_like	314..518	CDD:239801	96/215 (45%)
		Reprolysin	315..521	CDD:279729	98/217 (45%)
		ADAM_CR	<558..602	CDD:301627	17/48 (35%)
		TSP1	614..666	CDD:214559	30/51 (59%)
		ADAM_spacer1	773..886	CDD:283607	35/113 (31%)
		TSP1	901..956	CDD:214559	17/60 (28%)
adamts6	XP_002934253.2	Pep_M12B_propep	43..191	CDD:366707	51/157 (32%)
		ZnMc_ADAMTS_like	251..466	CDD:239801	97/216 (45%)
		ADAM_CR_2	481..549	CDD:375321	27/73 (37%)
		TSP1	562..614	CDD:214559	30/51 (59%)
		ADAM_spacer1	718..830	CDD:368694	35/117 (30%)
		TSP1	849..901	CDD:214559	17/59 (29%)
		TSP1	903..961	CDD:214559	16/62 (26%)
		TSP1	1023..1070	CDD:214559
		PLAC	1084..1116	CDD:370061
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	222	1.000	Domainoid score	I2530
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D125522at2759
OrthoFinder	1	1.000	-	-		FOG0001196
OrthoInspector	1	1.000	-	-		otm47784
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.920