DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment AdamTS-B and adamts15

DIOPT Version :9

Sequence 1:	NP_572247.2	Gene:	AdamTS-B / 31490	FlyBaseID:	FBgn0029791	Length:	1023	Species:	Drosophila melanogaster
Sequence 2:	XP_012822382.1	Gene:	adamts15 / 100489270	XenbaseID:	XB-GENE-6051208	Length:	938	Species:	Xenopus tropicalis

Alignment Length:	1025	Identity:	341/1025 - (33%)
Similarity:	483/1025 - (47%)	Gaps:	180/1025 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    48 LVVPRRVHPDGAFMTHQLEYAHELDHRRHRQRRSLNSEHDTQAADLHLLLPLA--NETLHLELMA 110
            :|:|:|:.||             |:.|.:     |..|:| .|.||.::..:.  .|..:|.|:.
Frog    30 VVIPKRLDPD-------------LNGRYY-----LKKEND-NAKDLGVIFQITAFYEDFYLNLIP 75

  Fly   111 HSYFLAPNL------VVERHRRDLRTRSPLTTRHLNCHFHGKVRGQPATNVAISTCAGLVGHIRT 169
            .:.|:||..      .:.:...|||          :|.:.|.|.....:..|:|.|.||.|....
Frog    76 DAQFIAPAFSMHFPGSIPKQSPDLR----------HCFYSGDVNSDRDSFAALSLCGGLRGAFGY 130

  Fly   170 AGNEYFIEPSKEHEPHPVNGHPHVVFQRSSVKPKHSLRKRNKRKRGGKSGSGAEVSNCGTREPRR 234
            .|.||.|.|.:......:         :||.:..|.|::|.     |...|....|.||.
Frog   131 QGEEYLIRPLQNVTRDQL---------QSSHQGPHLLQRRK-----GPLKSVDTTSRCGV----- 176

  Fly   235 RMETRLEWQARGKVKVQGGRQIRRHHHHHHHHHHKHKYRHHQQKISRVPHTKFKYETQFQTEPDH 299
                       |....||..:..          :|:|..|::::::   .|:.|        ..|
Frog   177 -----------GSGLNQGIMEAL----------NKYKGSHNKKQLN---GTRLK--------GSH 209

  Fly   300 AEIPRRRRSISSPRHVETLIVADATMSAFH-RDLNGYLLTIMNMVSALYKDPSIGNSIEIVVVRI 363
                |.||..|..|:||||||||.||..|| .||..||||:|...:.||:.|||.|.|.||||:.
Frog   210 ----RSRRFASITRYVETLIVADETMLKFHGDDLQHYLLTLMATAARLYRHPSIQNPINIVVVKF 270

  Fly   364 IQLDEEESQLQLNLTQNAQKNLDRFCSWQHKLNKGSEKDPHHHDVAILITRKNIC-ANNCMTLGL 427
            :.|.::....:  :|.||...|..||.||.|.||.|:|.|.:.|.|||.|:.::| |:.|.|||:
Frog   271 MVLTDDGKGPK--VTTNAAMTLRSFCGWQKKWNKVSDKHPEYWDTAILFTKMDLCGASTCDTLGM 333

  Fly   428 ANVGGMCKPKQSCSVNEDNGIMLSHTITHELGHNFGMFHDTAKIGCHPRVGPI--VHIMTPTFGA 490
            |:||.||.||:||||.||:|:..:.|..|||||.|.|.||..|: |....|.:  .::|:||.
Frog   334 ADVGTMCDPKRSCSVIEDDGLPSAFTTAHELGHVFNMPHDNVKV-CEEAFGKLRENYMMSPTL-- 395

  Fly   491 DTLQV----CWSNCSRKYITHFLDQGLGEC-LDDPPTPLDEYNYTGELPGMRYNARGQCRLQFNL 550
              :|:    .||.||...||.|||.|.||| ||:|..|:   :...||||.||:...||.|.|.|
Frog   396 --IQIDRANPWSACSAAIITDFLDSGHGECLLDEPAKPI---SLPEELPGARYSLSRQCELAFGL 455

  Fly   551 TTDSEVGACSAPH-EFCSTLWC--KVNGE--CVTHMRPTAPGTLCGRNKWCQNGKCVRREEL--A 608
                  |:...|: ::|:.|||  :..|:  |.|...|.|.||.||..|:|.||.||.|..:  .
Frog   456 ------GSKPCPYMQYCTKLWCTGRARGQLVCQTRHFPWADGTSCGDGKFCLNGACVERHNVNRY 514

  Fly   609 AVNGGWGDWSEWSECSRSCGGGVSTQQRECDNPVPANGGVFCIGERKRYKICRKRPCPAEEPSFR 673
            .|:|.||.||.:.:|||:|||||...:|||:||.|:|||.||.|.|.:|:.|...|||....|||
Frog   515 KVDGAWGKWSPYGQCSRTCGGGVQLAKRECNNPEPSNGGSFCEGLRVKYRSCSLNPCPETGKSFR 579

  Fly   674 AQQCARFDNVSYQ----GATYKWLPFFDKNNP---CKLFCSDVDDTIIANWGATVLDGTPCTLGT 731
            .:||..|:..::.    ..|..|:|.:...:|   |||.|..............|:|||||:...
Frog   580 EEQCESFNGFNHSTNRITQTVGWVPKYSGVSPRDKCKLICRANGTGYFYVLSPKVVDGTPCSPDA 644

  Fly   732 NNMCIDGICKKVGCDWIVDSEVQDDRCGVCGGSGDQCQPVRETYTDPFAAKDGAYVEIVTIPARA 796
            .::|:.|.|.|.|||..:.|:.:.|:|.||||....|:.:...:|.|.    ..|..:|||||.|
Frog   645 TSVCVQGKCIKAGCDGQLGSKKKYDKCRVCGGDNKSCKKISGLFTKPI----HGYNFVVTIPAGA 705

  Fly   797 RHILIRE-----LANSPHFLAIATGDGGDRFYLNGDSLISMPGEFEIAGAESL--YDRVDEQ-ET 853
            .::.:|:     |.|..::||:....|  |:.|||:.::: .||.:|:...||  |...... ||
Frog   706 SNLDVRQRGYKGLINDDNYLAVKNAQG--RYLLNGNYIVA-AGERDISVRGSLLKYSGTGTAVET 767

  Fly   854 ITIPQPIQHSISLYAIVRGNESNAGIFYEFTLP-----------ALNVTAG---------RQFQW 898
            :.....||.|:::..:..|..:...:.|.|.:|           ..|..||         .|..|
Frog   768 LQAINVIQESLTIEVLCVGKMTPPRLRYSFYIPREKKDGKVGQVISNSLAGLPPPLPRLKPQSNW 832

  Fly   899 RLSNWTACSASCGGGVQHREPICQENGKALGDTLPCWTHAKNKRPARQSRGCGDQPCPAHWWPGP 963
            ...||..||.|||.|.|.|...|::..:.|..  .|....   ||: :.|.||| |||. |..|.
Frog   833 IAGNWGDCSVSCGTGHQIRTIECRDPWEQLAS--DCQAAL---RPS-ERRTCGD-PCPV-WDAGE 889

  Fly   964 WQFCPVTCRPVGFVAPPQRRRSVVCLDEHDVVVADAECGHLQKPAEMEPC 1013
            |..|..:|.. ||     :||.:.|..:..|.:....|...:||.|::.|
Frog   890 WSSCSKSCGR-GF-----KRRQLRCSADGGVTLPREHCHLKRKPQELDFC 933

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AdamTS-B	NP_572247.2	Pep_M12B_propep	78..194	CDD:279848	29/123 (24%)
		ZnMc_ADAMTS_like	314..518	CDD:239801	100/212 (47%)
		Reprolysin	315..521	CDD:279729	102/214 (48%)
		ADAM_CR	<558..602	CDD:301627	18/48 (38%)
		TSP1	614..666	CDD:214559	28/51 (55%)
		ADAM_spacer1	773..886	CDD:283607	33/120 (28%)
		TSP1	901..956	CDD:214559	20/54 (37%)
adamts15	XP_012822382.1	Pep_M12B_propep	30..158	CDD:366707	39/165 (24%)
		ZnMc_ADAMTS_like	219..425	CDD:239801	101/212 (48%)
		ADAM_CR_2	439..506	CDD:375321	28/72 (39%)
		TSP1	520..572	CDD:214559	28/51 (55%)
		ADAM_spacer1	682..800	CDD:368694	33/124 (27%)
		TSP1	835..883	CDD:214559	20/54 (37%)
		TSP1	884..938	CDD:214559	16/57 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D125522at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.920