Protein Alignment AdamTS-B and adamtsl4

DIOPT Version :10

• Sequence 1: NP_572247.2
• Gene: AdamTS-B / 31490
• FlyBaseID: FBgn0029791
• Length: 1023
• Species: Drosophila melanogaster
• Sequence 2: XP_002935503.2
• Gene: adamtsl4 / 100488255
• XenbaseID: XB-GENE-986796
• Length: 1427
• Species: Xenopus tropicalis
• Alignment Length: 1208
• Identity: 263/1208 - (21%)
• Similarity: 392/1208 - (32%)
• Gaps: 384/1208 - (31%)

  Fly    28 GGVRPLYGLHSDELVAGEGQLVVP------------RRVHPDGAFMTHQLEYAHE-------LDH 73
            |..||.|.||:|      |::..|            .|.:|   |..|..:..|.       .:|
 Frog   108 GAARPAYPLHTD------GEIAAPFVDLGAQRHSPALRYNP---FNRHTRQGIHSSGSQPPVQNH 163

  Fly    74 RRHRQRRSLNSEHDTQAADLHLL-----LPLANETLHLELMAHSYFLAPNLVVERHRRDLRT-RS 132
            ......||.:|.  .:||..|..     .||....|..||:|...|       ..||.|.:: .|
 Frog   164 DSSPYHRSTSSR--GRAAARHPQTGWHPAPLETPYLQEELLAPETF-------SMHRNDHQSIPS 219

  Fly   133 PLTTRHLNCHFHGKVRGQPATNVAISTCAGLVGHIRTAGNEYFIEPSKEHEP----HPVNGHPHV 193
            ....|::.....     .||..........|:..          |.|::|.|    .|:......
 Frog   220 SYNRRNITRQVE-----DPAPWPFFPDSIPLLKP----------ESSEDHNPGRSFPPLTPTKES 269

  Fly   194 VFQ-----RSSVK-------------PKHSLRKRNKR-KRGGKSGSGAEVSNCGTREPRRRMETR 239
            .|.     |:|:|             |.|..::.::| ||..||..|      |..|....:|..
 Frog   270 RFSRRSRVRNSIKPGKYGYGKVPFALPLHKDKEESQRFKRHHKSLDG------GATEEEEHLEPT 328

  Fly   240 LEWQARGKVKVQGGRQIRRHHHHHHHHHHKHKYRHHQQKISR---VPHTKFKYETQFQTEPDHAE 301
                   ::.....|::...|:......|..:....:..:|.   :||.......| :|..:|:.
 Frog   329 -------QIPSINDREVYDTHNADSSVIHSPEPSKQKSSLSHKGDLPHHHLPDRKQ-KTVHEHSS 385

  Fly   302 IPRRRRSISSPRHVETLIVADATMSAFHRDLNGYLLTIMNMVSALYKDPSIGNSIEIVVVRIIQL 366
            .|            |||:.....|.     |:|:      ...||..|.|...|:|..|..:..:
 Frog   386 WP------------ETLVNISLLMG-----LSGF------QQKALKGDESRHESMETDVAPVEPV 427

  Fly   367 DEEE-SQLQLNLTQNAQKNLDRFCSWQHKLNKGSEKDPHHHDVAILITRKNICANNCMTLGLANV 430
            .||. |..:....||.|. |.....|      |||||...|                   |..|:
 Frog   428 QEEGLSHRRSQSNQNDQL-LSEIRYW------GSEKDSERH-------------------GDQNI 466

  Fly   431 GGMCKPKQSCSVNEDNGIMLSHTITHELGHNFGMFHDTAKIGCHPRVGPIVHIMTPTFGADTLQV 495
            |...:.:::                     :......|.|:.     .|...::.    ||..|.
 Frog   467 GSEKQVEEA---------------------HLSRIAKTRKVR-----SPNTRVLL----ADEKQA 501

  Fly   496 CWSNCSRKYITHFLDQGLGECLDDPPTPLDEYNYTGELPGM----------------------RY 538
            .....|...::....:.:. ..|:..|..|.||..|:.|.|                      |.
 Frog   502 AVEQKSSSLLSSATAEEIA-AADNSKTQSDVYNRNGDQPFMENRKDIRRISRAKMFGTVKPMQRL 565

  Fly   539 NA--RGQ----------------CRLQFNLT--------TDSEVGACSAPHEFCSTLWCKVNGEC 577
            :|  :||                ..|..::.        :|||:.|..|...
 Frog   566 DATKKGQNERSPLEGSVLLNERASHLNSHVKKITKHSDGSDSEITADEADQH------------- 617

  Fly   578 VTHMRPTAPGTLCGRNK---------WCQNGKCVR---REELAAVNGGWGDWSEWSECSRSCGGG 630
              |.:..:...|..|::         ...|.:..:   ||..:.......|  .|....||
 Frog   618 --HHQVASDSVLLPRSRSQRQSQNRHGVDNSRVFQNLFREHPSVHRPAQSD--PWPAFGRS---- 674

  Fly   631 VSTQQRECDNPV-----------------PANGGVFCIGERKRYKICRKRPCPAEEPSFRAQQCA 678
             .|...|.:..|                 ||:....|.||:|:||.|.:..||:.:|..||:.||
 Frog   675 -PTVAHEREQDVGSSLHQNSELPQWNLYNPASEEFHCEGEQKQYKSCNQEACPSGQPDARAKHCA 738

  Fly   679 RFDNVSYQGATYKWLPFFD--KNNPCKLFCSDVDDTIIANWGATVLDGTPCTLGTNNMCIDGICK 741
            .|::..:.|..|:|..|.:  .|..|.|.|..:...........|.|||||..|:.::|:||.|.
 Frog   739 TFNSQEFMGRLYQWEAFTEVSGNQRCALNCRPIGYRFYVRHTEKVQDGTPCEAGSLDVCVDGQCL 803

  Fly   742 KVGCDWIVDSEVQDDRCGVCGGSGDQCQPVRETYTD---PFAAKDGAYVEIVTIPARARHILIRE 803
            ..|||.|:.|....|.||||||.|..|:.:..|:.:   |.     .|.:|:.||..|..|.:||
 Frog   804 SPGCDGILGSNSTLDTCGVCGGDGSTCKFITGTFKETNVPI-----GYHKILEIPKGATQIKVRE 863

  Fly   804 LANSPHFLAIATGDGGDRFYLNGDSLISMPGEFEIAGAESLYDR----VDEQETITIPQPIQHSI 864
            |..||::||:.:..|  :.::||:..:...|.:|..|...:|.:    ..|.||.|...|...::
 Frog   864 LTWSPNYLALRSRTG--KSFINGNWAVDPAGRYEAGGTVFIYTQPGREEQEGETFTAAGPTSEAL 926

  Fly   865 SLYAIVRGNESNAGIFYEFTLPA-----------------------------LNVTAGR------ 894
            .:|.|.:  :.|.||.::|.:.:                             |..|..|
 Frog   927 DVYMIFQ--QDNPGISFQFFISSPTAADASGHQSNPSQQEYGALRSMSASETLANTGSRTQPPDD 989

  Fly   895 --------------------------------------QFQWRLSNWTACSASCGGGVQHREPIC 921
                                                  ||.|:....||||.|||.|..:  |:.
 Frog   990 RPLVPPPQSRQRPVSTLQRNIRVPPLQSPPVHYWPEQPQFFWKRVGSTACSVSCGKGFWY--PVY 1052

  Fly   922 Q-ENGKALGDTLPCWTHAKNKRPARQSRGCGDQPCPAHWWPGPWQFCPVTCRPVGFVAPPQRRRS 985
            | .:..:|.:.........|| |..|...|..|||||.|..|.|..|..||      ....:.|.
 Frog  1053 QCVSRNSLEEVSEEECDLSNK-PFPQEEACNTQPCPAFWDVGNWSVCSRTC------GNGIQHRQ 1110

  Fly   986 VVCLD---EHDVVVADAECGHLQKPAEMEPCESSLPIC 1020
            |:|..   ....:|....|.||.||...:.|:  |.||
 Frog  1111 VLCRQMYANRTTMVHPQRCSHLVKPNVTQTCQ--LRIC 1146

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
AdamTS-B	NP_572247.2	Pep_M12B_propep	47..195	CDD:460254	33/176 (19%)
		ZnMc_ADAMTS_like	314..518	CDD:239801	37/204 (18%)
		ADAMTS_CR_2	534..602	CDD:465496	16/124 (13%)
		TSP1	614..666	CDD:214559	16/68 (24%)
		ADAMTS_CR_3	672..768	CDD:437068	37/97 (38%)
		ADAMTS_spacer1	770..886	CDD:461796	33/122 (27%)
		TSP1	901..956	CDD:214559	18/55 (33%)
		TSP1_ADAMTS	959..1020	CDD:465950	17/63 (27%)
adamtsl4	XP_002935503.2	TSP1	45..>77	CDD:214559
		ADAMTS_CR_3	729..830	CDD:437068	38/100 (38%)
		ADAMTS_spacer1	832..945	CDD:461796	33/121 (27%)
		TSP1_ADAMTS	1037..1086	CDD:465950	17/51 (33%)
		TSP1_ADAMTS	1090..1146	CDD:465950	17/63 (27%)
		TSP1_ADAMTS	1149..1203	CDD:465950
		TSP1_ADAMTS	1207..1260	CDD:465950
		TSP1_ADAMTS	1266..1322	CDD:465950
		TSP1_ADAMTS	1326..1377	CDD:465950
		PLAC	1385..1414	CDD:462560