DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment AdamTS-B and adamtsl4

DIOPT Version :9

Sequence 1:	NP_572247.2	Gene:	AdamTS-B / 31490	FlyBaseID:	FBgn0029791	Length:	1023	Species:	Drosophila melanogaster
Sequence 2:	XP_002935503.2	Gene:	adamtsl4 / 100488255	XenbaseID:	XB-GENE-986796	Length:	1427	Species:	Xenopus tropicalis

Alignment Length:	1208	Identity:	263/1208 - (21%)
Similarity:	392/1208 - (32%)	Gaps:	384/1208 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 GGVRPLYGLHSDELVAGEGQLVVP------------RRVHPDGAFMTHQLEYAHE-------LDH 73
            |..||.|.||:|      |::..|            .|.:|   |..|..:..|.       .:|
Frog   108 GAARPAYPLHTD------GEIAAPFVDLGAQRHSPALRYNP---FNRHTRQGIHSSGSQPPVQNH 163

  Fly    74 RRHRQRRSLNSEHDTQAADLHLL-----LPLANETLHLELMAHSYFLAPNLVVERHRRDLRT-RS 132
            ......||.:|.  .:||..|..     .||....|..||:|...|       ..||.|.:: .|
Frog   164 DSSPYHRSTSSR--GRAAARHPQTGWHPAPLETPYLQEELLAPETF-------SMHRNDHQSIPS 219

  Fly   133 PLTTRHLNCHFHGKVRGQPATNVAISTCAGLVGHIRTAGNEYFIEPSKEHEP----HPVNGHPHV 193
            ....|::.....     .||..........|:..          |.|::|.|    .|:......
Frog   220 SYNRRNITRQVE-----DPAPWPFFPDSIPLLKP----------ESSEDHNPGRSFPPLTPTKES 269

  Fly   194 VFQ-----RSSVK-------------PKHSLRKRNKR-KRGGKSGSGAEVSNCGTREPRRRMETR 239
            .|.     |:|:|             |.|..::.::| ||..||..|      |..|....:|..
Frog   270 RFSRRSRVRNSIKPGKYGYGKVPFALPLHKDKEESQRFKRHHKSLDG------GATEEEEHLEPT 328

  Fly   240 LEWQARGKVKVQGGRQIRRHHHHHHHHHHKHKYRHHQQKISR---VPHTKFKYETQFQTEPDHAE 301
                   ::.....|::...|:......|..:....:..:|.   :||.......| :|..:|:.
Frog   329 -------QIPSINDREVYDTHNADSSVIHSPEPSKQKSSLSHKGDLPHHHLPDRKQ-KTVHEHSS 385

  Fly   302 IPRRRRSISSPRHVETLIVADATMSAFHRDLNGYLLTIMNMVSALYKDPSIGNSIEIVVVRIIQL 366
            .|            |||:.....|.     |:|:      ...||..|.|...|:|..|..:..:
Frog   386 WP------------ETLVNISLLMG-----LSGF------QQKALKGDESRHESMETDVAPVEPV 427

  Fly   367 DEEE-SQLQLNLTQNAQKNLDRFCSWQHKLNKGSEKDPHHHDVAILITRKNICANNCMTLGLANV 430
            .||. |..:....||.|. |.....|      |||||...|                   |..|:
Frog   428 QEEGLSHRRSQSNQNDQL-LSEIRYW------GSEKDSERH-------------------GDQNI 466

  Fly   431 GGMCKPKQSCSVNEDNGIMLSHTITHELGHNFGMFHDTAKIGCHPRVGPIVHIMTPTFGADTLQV 495
            |...:.:::                     :......|.|:.     .|...::.    ||..|.
Frog   467 GSEKQVEEA---------------------HLSRIAKTRKVR-----SPNTRVLL----ADEKQA 501

  Fly   496 CWSNCSRKYITHFLDQGLGECLDDPPTPLDEYNYTGELPGM----------------------RY 538
            .....|...::....:.:. ..|:..|..|.||..|:.|.|                      |.
Frog   502 AVEQKSSSLLSSATAEEIA-AADNSKTQSDVYNRNGDQPFMENRKDIRRISRAKMFGTVKPMQRL 565

  Fly   539 NA--RGQ----------------CRLQFNLT--------TDSEVGACSAPHEFCSTLWCKVNGEC 577
            :|  :||                ..|..::.        :|||:.|..|...
Frog   566 DATKKGQNERSPLEGSVLLNERASHLNSHVKKITKHSDGSDSEITADEADQH------------- 617

  Fly   578 VTHMRPTAPGTLCGRNK---------WCQNGKCVR---REELAAVNGGWGDWSEWSECSRSCGGG 630
              |.:..:...|..|::         ...|.:..:   ||..:.......|  .|....||
Frog   618 --HHQVASDSVLLPRSRSQRQSQNRHGVDNSRVFQNLFREHPSVHRPAQSD--PWPAFGRS---- 674

  Fly   631 VSTQQRECDNPV-----------------PANGGVFCIGERKRYKICRKRPCPAEEPSFRAQQCA 678
             .|...|.:..|                 ||:....|.||:|:||.|.:..||:.:|..||:.||
Frog   675 -PTVAHEREQDVGSSLHQNSELPQWNLYNPASEEFHCEGEQKQYKSCNQEACPSGQPDARAKHCA 738

  Fly   679 RFDNVSYQGATYKWLPFFD--KNNPCKLFCSDVDDTIIANWGATVLDGTPCTLGTNNMCIDGICK 741
            .|::..:.|..|:|..|.:  .|..|.|.|..:...........|.|||||..|:.::|:||.|.
Frog   739 TFNSQEFMGRLYQWEAFTEVSGNQRCALNCRPIGYRFYVRHTEKVQDGTPCEAGSLDVCVDGQCL 803

  Fly   742 KVGCDWIVDSEVQDDRCGVCGGSGDQCQPVRETYTD---PFAAKDGAYVEIVTIPARARHILIRE 803
            ..|||.|:.|....|.||||||.|..|:.:..|:.:   |.     .|.:|:.||..|..|.:||
Frog   804 SPGCDGILGSNSTLDTCGVCGGDGSTCKFITGTFKETNVPI-----GYHKILEIPKGATQIKVRE 863

  Fly   804 LANSPHFLAIATGDGGDRFYLNGDSLISMPGEFEIAGAESLYDR----VDEQETITIPQPIQHSI 864
            |..||::||:.:..|  :.::||:..:...|.:|..|...:|.:    ..|.||.|...|...::
Frog   864 LTWSPNYLALRSRTG--KSFINGNWAVDPAGRYEAGGTVFIYTQPGREEQEGETFTAAGPTSEAL 926

  Fly   865 SLYAIVRGNESNAGIFYEFTLPA-----------------------------LNVTAGR------ 894
            .:|.|.:  :.|.||.::|.:.:                             |..|..|
Frog   927 DVYMIFQ--QDNPGISFQFFISSPTAADASGHQSNPSQQEYGALRSMSASETLANTGSRTQPPDD 989

  Fly   895 --------------------------------------QFQWRLSNWTACSASCGGGVQHREPIC 921
                                                  ||.|:....||||.|||.|..:  |:.
Frog   990 RPLVPPPQSRQRPVSTLQRNIRVPPLQSPPVHYWPEQPQFFWKRVGSTACSVSCGKGFWY--PVY 1052

  Fly   922 Q-ENGKALGDTLPCWTHAKNKRPARQSRGCGDQPCPAHWWPGPWQFCPVTCRPVGFVAPPQRRRS 985
            | .:..:|.:.........|| |..|...|..|||||.|..|.|..|..||      ....:.|.
Frog  1053 QCVSRNSLEEVSEEECDLSNK-PFPQEEACNTQPCPAFWDVGNWSVCSRTC------GNGIQHRQ 1110

  Fly   986 VVCLD---EHDVVVADAECGHLQKPAEMEPCESSLPIC 1020
            |:|..   ....:|....|.||.||...:.|:  |.||
Frog  1111 VLCRQMYANRTTMVHPQRCSHLVKPNVTQTCQ--LRIC 1146

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AdamTS-B	NP_572247.2	Pep_M12B_propep	78..194	CDD:279848	26/125 (21%)
		ZnMc_ADAMTS_like	314..518	CDD:239801	37/204 (18%)
		Reprolysin	315..521	CDD:279729	38/206 (18%)
		ADAM_CR	<558..602	CDD:301627	6/52 (12%)
		TSP1	614..666	CDD:214559	16/68 (24%)
		ADAM_spacer1	773..886	CDD:283607	33/119 (28%)
		TSP1	901..956	CDD:214559	18/55 (33%)
adamtsl4	XP_002935503.2	TSP1	45..>77	CDD:214559
		ADAM_spacer1	831..945	CDD:368694	33/122 (27%)
		TSP1_ADAMTS	1037..1086	CDD:408800	17/51 (33%)
		TSP1_ADAMTS	1090..1146	CDD:408800	17/63 (27%)
		TSP1_ADAMTS	1149..1203	CDD:408800
		TSP1_ADAMTS	1207..1260	CDD:408800
		TSP1_ADAMTS	1266..1322	CDD:408800
		TSP1_ADAMTS	1326..1377	CDD:408800
		PLAC	1385..1414	CDD:400844
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910