DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment AdamTS-B and adamts5

DIOPT Version :9

Sequence 1:	NP_572247.2	Gene:	AdamTS-B / 31490	FlyBaseID:	FBgn0029791	Length:	1023	Species:	Drosophila melanogaster
Sequence 2:	XP_002935740.1	Gene:	adamts5 / 100488158	XenbaseID:	XB-GENE-961098	Length:	913	Species:	Xenopus tropicalis

Alignment Length:	931	Identity:	283/931 - (30%)
Similarity:	416/931 - (44%)	Gaps:	149/931 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    67 YAHELDHRRHRQRRSLNSEHDTQ----AADLHLLLPLANETLHLELMAHSYFLAPNLVVE----- 122
            |.|   ||...||||...::..|    ...:..:|....:...|:|......|:|:...:
Frog    39 YKH---HRGEHQRRSGIVQNIDQIYAGGGKVGYILYADGKKFLLDLERDELLLSPHFSTKYLGRL 100

  Fly   123 --RHRRDLRTRSPLTTRHLNCHFHGKVRGQPATNVAISTCAGLVGHIRTAGNEYFIEP---SKEH 182
              :||         ..||  |.:.|.|...|.:....:.|.||.|:.......|.|:|   ....
Frog   101 HPQHR---------FQRH--CFYRGTVDSSPQSLAVFNLCGGLDGYFAVKHAHYTIKPLIKGTAG 154

  Fly   183 EPHPV-NGHPHVV-------FQRSSVKPKHSLRKRNKRKRGGKSGSGAEVSNCGTREPRRRMETR 239
            |.|.. :|...|:       |...:|..:.|......|||..|.|.||      ||.|
Frog   155 EGHVYSDGSERVLHAFIKDRFSFETVPTRASCETHGLRKRLHKHGKGA------TRHP------- 206

  Fly   240 LEWQARGKVKVQGGRQIRRHHHHHHHHHHKHKYRHHQQKISRVPHTKFKYETQFQTEPDHAEIPR 304
                                  |.|....::..:.:|......|:.|   ||.||:.   |...|
Frog   207 ----------------------HQHQQTQENPQKANQTSAPSDPNLK---ETLFQST---ALKKR 243

  Fly   305 RRRSISSPRHVETLIVADATMS-AFHRDLNGYLLTIMNMVSALYKDPSIGNSIEIVVVRIIQLDE 368
            :|||:|..|.||.|:|||.:|: .:.:||:.||||:.::.|.||..|||.|.|.:.||:::.|.:
Frog   244 QRRSVSKSRQVELLLVADESMAKKYGKDLHHYLLTLASIASRLYSHPSIENHIRLAVVKVVMLTD 308

  Fly   369 EESQLQLNLTQNAQKNLDRFCSWQHKLNKGSEKDPHHHDVAILITRKNICA-NNCMTLGLANVGG 432
            ::...:  :::||...|..||.|||:.|:..::...|:|.|||.||:::|. ::|.|||:|:||.
Frog   309 KDKGPE--VSKNAATTLKNFCKWQHQHNQLDDEHDQHYDAAILFTREDLCGHHSCDTLGMADVGT 371

  Fly   433 MCKPKQSCSVNEDNGIMLSHTITHELGHNFGMFHDTAKIGCHPRVGPI--VHIMTPTFGADTLQV 495
            :|.|::||:|.||:|:..:.|:.||:||..|:.||.:|. |....|.:  ..:|:....:.....
Frog   372 ICSPERSCAVIEDDGLHAAFTVAHEIGHLLGLSHDDSKF-CEENFGSLEDKRLMSSVLTSIDASK 435

  Fly   496 CWSNCSRKYITHFLDQGLGECLDDPPTPLDEYNYTGELPGMRYNARGQCRLQFNLTTDSEVGACS 560
            .||.|:...||.|||.|.|.||.|.|.  ::.....||||..|:|..||:|.|..|.....|.
Frog   436 PWSKCTSATITDFLDDGHGNCLLDQPR--NQILGPEELPGQSYDAIRQCKLAFGPTYTVCPGM-- 496

  Fly   561 APHEFCSTLWCKV--NGE--CVTHMRPTAPGTLCGRNKWCQNGKCVRREE----LAAVNGGWGDW 617
               :.||.|||.|  .|:  |:|...|...||.||:.:.|.:||||.:.:    ..:.:|.||.|
Frog   497 ---DVCSRLWCAVVRQGQMVCLTKKLPAVEGTPCGKGRICLHGKCVDKNKKKYYSVSSHGNWGSW 558

  Fly   618 SEWSECSRSCGGGVSTQQRECDNPVPANGGVFCIGERKRYKICRKRPCPAEEPSFRAQQCARFDN 682
            ..|.:|||:|||||....|.|:||.|.|.|.:|||:|..|:.|...|||:...|||.|||...:.
Frog   559 GPWGQCSRTCGGGVQFAYRHCNNPAPKNSGKYCIGKRAIYRSCNVTPCPSNAKSFRQQQCEARNG 623

  Fly   683 VSYQGATYK----WLPFFDKNNP---CKLFCSDVDDTIIANWGATVLDGTPCTLGTNNMCIDGIC 740
            ........|    |:|.:....|   |||.|..........:...|.|||.|...:|::|:.|.|
Frog   624 YQTDAKGVKTFVEWVPKYAGVQPGDVCKLICQAKGTGYYVVFSQKVTDGTECRPYSNSVCVRGKC 688

  Fly   741 KKVGCDWIVDSEVQDDRCGVCGGSGDQCQPVRETYTDPFAAKDGAYVEIVTIPARARHILIRELA 805
            .:.|||.|:.|::|.|:||:|||....|..|..|:|    .|...|.:||.||..|.||.:|:..
Frog   689 VRTGCDGIIGSKLQFDKCGICGGDNSSCTKVMGTFT----TKSKGYTDIVKIPEGATHIKVRQYK 749

  Fly   806 NSPH-----FLAIATGDGGDRFYLNG-------DSLISMPG-EFEIAG---AESLYDRVDEQETI 854
            ....     :||:....|  .:..||       :::|.|.| ....:|   ||.:...:....|
Frog   750 AKDQTRFTAYLALKKKSG--EYITNGKYMISTSETIIEMNGFVMNYSGWSHAEDMLHSMGHSST- 811

  Fly   855 TIPQPIQHSISLYAIVRGNESNAGIFYEFTLPALNVTAGR-------------QFQWRLSNWTAC 906
                  |..:.:..:.........:.|.|.:|:..|....             |.||....|.:|
Frog   812 ------QEVLIVQILATDQSKPLDVRYSFYVPSKQVPNTNSINNINNVVPKISQPQWVTGPWLSC 870

  Fly   907 SASCGGGVQHREPICQE-NGK 926
            |.:|..|...|...||: :||
Frog   871 SRTCDTGWHTRTVQCQDGHGK 891

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AdamTS-B	NP_572247.2	Pep_M12B_propep	78..194	CDD:279848	28/130 (22%)
		ZnMc_ADAMTS_like	314..518	CDD:239801	79/207 (38%)
		Reprolysin	315..521	CDD:279729	81/209 (39%)
		ADAM_CR	<558..602	CDD:301627	17/47 (36%)
		TSP1	614..666	CDD:214559	26/51 (51%)
		ADAM_spacer1	773..886	CDD:283607	27/128 (21%)
		TSP1	901..956	CDD:214559	10/27 (37%)
adamts5	XP_002935740.1	Pep_M12B_propep	41..159	CDD:366707	30/131 (23%)
		ZnMc_ADAMTS_like	252..458	CDD:239801	80/208 (38%)
		ADAM_CR_2	472..539	CDD:375321	27/71 (38%)
		TSP1	555..607	CDD:214559	26/51 (51%)
		ADAM_spacer1	717..837	CDD:368694	28/132 (21%)
		TSP1	862..913	CDD:214559	11/30 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D125522at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010