DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment AdamTS-B and adamts12

DIOPT Version :9

Sequence 1:	NP_572247.2	Gene:	AdamTS-B / 31490	FlyBaseID:	FBgn0029791	Length:	1023	Species:	Drosophila melanogaster
Sequence 2:	XP_017946319.2	Gene:	adamts12 / 100380018	XenbaseID:	XB-GENE-959575	Length:	1569	Species:	Xenopus tropicalis

Alignment Length:	1018	Identity:	365/1018 - (35%)
Similarity:	522/1018 - (51%)	Gaps:	150/1018 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    37 HSDELVAGEGQLVVPRRVHPDGAFMTHQLEYAHELDHRRHRQRRSLNSEHDTQAADLHLLLPLAN 101
            |.|..:....::|.|.:|...|.|:::.|:         ||::||:.|:      .:|..:....
Frog    55 HLDHSLPLAFEVVEPVKVDEKGNFLSYNLQ---------HRRKRSVASQ------AIHYRIHHKT 104

  Fly   102 ETLHLELMAHSYFLAPNLVVERHRRDLRTRSPLTTRHLN-CHFHG-----KVRGQPATNVAISTC 160
            ..|...|.....||:.|.::|| |....:.:.::.:..| ||..|     .|.|..|   |||.|
Frog   105 HNLFFNLTFRDGFLSDNFILER-RNGNSSHARISPQLGNGCHLIGTAQRAHVGGGVA---AISVC 165

  Fly   161 AGLVGHIRTAGNEYFIEPSKEHEPHPVNG--HPHVVFQRSSVKPKHSLRKRNKRKRGGKSGSGAE 223
            .||.|..|....:|||||.  |....|:|  |.|:::||.|   .|    ||:|:....:|....
Frog   166 NGLAGFFRLPDGDYFIEPF--HGATQVSGKPHQHIIYQRDS---PH----RNRRELPISTGDFCA 221

  Fly   224 VSNCGTREPRRRMETRLEWQARGKVKVQGGRQIRRHHHHHHHHHHKHKYRHHQQKISRVPHTKFK 288
            | |..::...::...|.||:             |:|              .:.:|||
Frog   222 V-NDNSKSVLQQERQREEWE-------------RKH--------------LNGRKIS-------- 250

  Fly   289 YETQFQTEPDHAEIPRRRRSISSPRHVETLIVADATMSAFH--RDLNGYLLTIMNMVSALYKDPS 351
                             :||:|..|.||||:|||..|.|:|  .::..|:.||||||:.|:.||:
Frog   251 -----------------QRSVSKERWVETLVVADTKMIAYHGSNNVESYIFTIMNMVTGLFHDPN 298

  Fly   352 IGNSIEIVVVRIIQLDEEESQLQLNLTQNAQKNLDRFCSWQHKLNKGSEKDPHHHDVAILITRKN 416
            |||:|.|.|||:|.|:|||..|:  :..||.:.|..||.||..:|..|:..|.|||||:|:|||:
Frog   299 IGNAIHIKVVRLILLEEEEEGLK--IVHNADQTLASFCKWQKSINPKSDAHPAHHDVAVLLTRKD 361

  Fly   417 ICANN---CMTLGLANVGGMCKPKQSCSVNEDNGIMLSHTITHELGHNFGMFHDTAKIGCHPRVG 478
            |||:.   |.||||:::.|||:|.:||::|||.|:.|:.||.|||||:||:.||.....|. ..|
Frog   362 ICASKNSPCETLGLSHLSGMCQPSKSCNINEDTGLPLAFTIAHELGHSFGIQHDGQGNDCE-IAG 425

  Fly   479 PIVHIMTPTFGADTLQVCWSNCSRKYITHFLDQGLGECLDDPPTPLDEYNYTGEL------PGMR 537
            ...:||:.....:|..:.||.||::|||.|||:|.|.||||.|...|       |      ||:.
Frog   426 RNPYIMSRQLQYNTSPLTWSPCSKEYITRFLDRGWGFCLDDVPAKKD-------LKPPIIAPGVL 483

  Fly   538 YNARGQCRLQF--NLTTDSEVGACSAPHEFCSTLWCKVNGECVTHMRPTAPGTLCGRNKWCQNGK 600
            |:...||:||:  |.|      .|......|.||||.|...|.:.:...|.||.||.:|||.|||
Frog   484 YDVNHQCQLQYGPNAT------FCEEVDNVCQTLWCSVKNSCRSKLDSAADGTRCGESKWCFNGK 542

  Fly   601 CVR-REELAAVNGGWGDWSEWSECSRSCGGGVSTQQRECDNPVPANGGVFCIGERKRYKICRKRP 664
            |:. ......:|||||.|:.||.|||:||.|....:|:|:||.|..||.:|.||||||:||..:|
Frog   543 CINVGTTPQTINGGWGAWTPWSHCSRTCGAGAENAERKCNNPQPKFGGKYCTGERKRYRICNIQP 607

  Fly   665 CPAEEPSFRAQQCARFDNVSYQGATYKWLPFFDKNNPCKLFCSDVDDTIIANWGATVLDGTPC-- 727
            ||.:.||||..||..|:.|.|:...|:|:|.::..|||:|.|..........:...|:|||||
Frog   608 CPKDYPSFREMQCTEFNTVPYKNELYQWIPIYNTENPCELHCRSSSGNFANKFLDAVIDGTPCFE 672

  Fly   728 TLGTNNMCIDGICKKVGCDWIVDSEVQDDRCGVCGGSGDQCQPVRETY--TDPFAAKDGAYVEIV 790
            ...:.::||:|||||||||:.:||...:||||:|.|.|..||.:::.:  ||.|     .||::.
Frog   673 RNKSRDVCINGICKKVGCDYEIDSNATEDRCGICLGDGSSCQTIKKVFNQTDGF-----GYVDVG 732

  Fly   791 TIPARARHILIRELANSPHFLAIATGDGGDRFYLNGDSLISMPGEFEIAGAESLYDRVDEQETIT 855
            .||..||.|.|.|:..:.:|||:.:.|.| ::||||..:|...||:::||....|.|.::.|.||
Frog   733 LIPKGARDIKIEEVEEAGNFLALRSEDPG-KYYLNGAYIIQWNGEYKVAGTIFHYQRNNDTENIT 796

  Fly   856 IPQPIQHSISLYAIVRGNESNAGIFYEFTLPA---LNVTAGRQFQWRLSNWTACSASCGGGVQHR 917
            ...|...||.:..:.:  |.|.|:.||:.:..   |.......:.||...||.|||:||.||||:
Frog   797 ASGPTNESIWIQLLFQ--EHNPGVRYEYVIQKDVNLENEIESVYTWRYGGWTDCSATCGTGVQHQ 859

  Fly   918 EPICQENGKALGDTLPCWTHAKNKRPARQSRGCGDQPCPAHWWPGPWQFCPVTCRPVGFVAPPQR 982
            ...|....:.:.....|   .:..:|..:.:.|..:.||..||.|.||.|..||.|.|     ::
Frog   860 ISRCVNKKRGVVKNTFC---DQEMQPITRQKKCNTKECPPRWWVGQWQQCSTTCGPTG-----EK 916

  Fly   983 RRSVVCL-----DEHDVVVADAECGHLQKPAEMEPCESSLPIC 1020
            :|:|:||     ||.  .:...:|.||.||.....|...: :|
Frog   917 KRTVLCLKTSGSDEE--ALRSEDCHHLTKPKVYLSCNRDI-LC 956

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AdamTS-B	NP_572247.2	Pep_M12B_propep	78..194	CDD:279848	37/123 (30%)
		ZnMc_ADAMTS_like	314..518	CDD:239801	101/208 (49%)
		Reprolysin	315..521	CDD:279729	104/210 (50%)
		ADAM_CR	<558..602	CDD:301627	19/43 (44%)
		TSP1	614..666	CDD:214559	28/51 (55%)
		ADAM_spacer1	773..886	CDD:283607	39/114 (34%)
		TSP1	901..956	CDD:214559	15/54 (28%)
adamts12	XP_017946319.2	Pep_M12B_propep	65..200	CDD:396235	45/155 (29%)
		ZnMc_ADAMTS_like	258..465	CDD:239801	102/209 (49%)
		ADAM_CR_2	480..544	CDD:407643	28/69 (41%)
		ADAM_CR	527..688	CDD:417715	74/160 (46%)
		TSP1	557..609	CDD:214559	28/51 (55%)
		ADAM_spacer1	714..825	CDD:368694	40/118 (34%)
		TSP1_ADAMTS	840..894	CDD:408800	17/56 (30%)
		TSP1_ADAMTS	898..952	CDD:408800	22/60 (37%)
		TSP1_ADAMTS	960..1008	CDD:408800
		TSP1_ADAMTS	1312..1360	CDD:408800
		TSP1_ADAMTS	1363..1418	CDD:408800
		TSP1_ADAMTS	1421..1467	CDD:408800
		TSP1_ADAMTS	1470..1525	CDD:408800
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	222	1.000	Domainoid score	I2530
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	617	1.000	Inparanoid score	I877
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D125522at2759
OrthoFinder	1	1.000	-	-		FOG0001196
OrthoInspector	1	1.000	-	-		otm47784
Panther	1	1.100	-	-	O	PTHR13723
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2816
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	7.160