DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment AdamTS-B and adamts13

DIOPT Version :9

Sequence 1:	NP_572247.2	Gene:	AdamTS-B / 31490	FlyBaseID:	FBgn0029791	Length:	1023	Species:	Drosophila melanogaster
Sequence 2:	XP_002663267.4	Gene:	adamts13 / 100320289	ZFINID:	ZDB-GENE-070814-7	Length:	1498	Species:	Danio rerio

Alignment Length:	810	Identity:	227/810 - (28%)
Similarity:	363/810 - (44%)	Gaps:	120/810 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   282 VPH----------TKFKY-ETQFQTEPDHAEIPRRRRS--ISSPRHVETLIVADATMSAFHR-DL 332
            |||          |:.|. ::||          |.|||  .|...::|..:|....:...|| |.
Zfish   184 VPHLLITQTLPVRTRLKQPKSQF----------RLRRSPLRSEVTYLELAVVVGPDVYEVHRQDT 238

  Fly   333 NGYLLTIMNMVSALYKDPSIGNSIEIVVVRIIQLDEEESQLQLNLTQNAQKNLDRFCSWQHKLNK 397
            ..|:||.:|:.|.|.:|.::|.:|.:.:||:|.|.|.|..:|  :::|...:|...|.|..|:|.
Zfish   239 ERYILTNLNIASELLRDVTLGANIRVHLVRMIILTEPEPDIQ--ISENITSSLKSVCEWGQKVNP 301

  Fly   398 GSEKDPHHHDVAILITRKNICA--NNCMTLGLANVGGMCKPKQSCSVNEDNGIMLSHTITHELGH 460
            .::.||.|.|:.:.|||.::..  .|.:..|:...||:|..:.:|.:.||.|..|..||.||:||
Zfish   302 DADSDPLHADLLLYITRFDLVLPNGNKLVRGVTQFGGVCSTQWNCVITEDTGFDLGITIAHEIGH 366

  Fly   461 NFGMFHDTAKIGCHPRVGPIVHIMTPTFGADTLQVCWSNCSRKYITHFLDQGLGECLDDPPT--- 522
            :||:.||    |..........:|....|.:::.:.||.|||..:..|...|..||:.|.|.
Zfish   367 SFGINHD----GIDNTCSSSGFMMASDGGYNSVDLTWSQCSRAQLYSFFRAGKAECVQDVPVLGG 427

  Fly   523 PLDEYNYTGELPGMRYNARGQCRLQFNLTTDSEVGACSAPHE---FCSTLWCKVN----GECVTH 580
            .:.::.     ||:.|....|||:.|.    |...|||..:|   .|..|.|.:|    ..|...
Zfish   428 SVQDWR-----PGLFYGVDDQCRIAFG----SSATACSFTNEDMTTCRVLSCHINPQDHSSCTRL 483

  Fly   581 MRPTAPGTLCGRNKWCQNGKCVRREELAA---VNGGWGDWSEWSECSRSCGGGVSTQQRECDNPV 642
            :.|...||.||.::||..|:||......:   |:|.|..||::|.|||:||||::.::|:|:||.
Zfish   484 LVPLLDGTECGPSQWCLKGRCVSPSTSGSSMMVHGSWSAWSDFSPCSRTCGGGITHRRRQCNNPR 548

  Fly   643 PANGGVFCIGERKRYKICRKRPCPAEEPSFRAQQCARFDNVSYQGAT-----YKWLP---FFDKN 699
            .|.||..|.|:....::|..:.|.:.:..|.|:||:..|......:|     |.|:|   :...:
Zfish   549 SAFGGTICKGQNTEAELCNLQLCDSTQLEFMARQCSATDQQPLSVSTDSKSMYTWIPAISYSSGD 613

  Fly   700 NPCKLFCSDVDDTIIANWGATVLDGTPCTL------GTNNMCIDGICKKVGCDWIVDSEVQDDRC 758
            :.|||.|...:...:.:.|:..:|||.|..      |:.:.|:.|.|:..|||..:.|...:|.|
Zfish   614 SQCKLMCRSREQDFMVSRGSQFIDGTRCESDNPVPHGSISACLSGKCQLFGCDGALHSGKVEDVC 678

  Fly   759 GVCGGSGDQCQPVRETYTDPFAAKDGAYVEIVTIPARARHILIRELANSPHFLAIATGDGGDRFY 823
            |||||:|..|..:..||:   ..|.|.||..:|:|..|..:.:....:....||:..   .|::.
Zfish   679 GVCGGNGSTCHLISNTYS---GGKAGEYVTFLTLPLNASQVHVFNTRSIFTHLAVLL---NDKYV 737

  Fly   824 LNGDSLISMPGEFEIAGAESLY--------DRVDEQETITIPQPIQHSISL-----YAIVRGNES 875
            ::|:....:...:.....:||.        |.:.:.|.:.|..|:...|.|     |....|:.:
Zfish   738 VSGNGKPGLSNTYPSPLEKSLITYKLYLTPDHLPQTEELYISGPVTDKIHLQVYRKYGQEYGDLT 802

  Fly   876 NAGIFYEFTLPALNVTAGRQFQWRLSNWTACSASCGGGVQHREPICQENGKALGDTLPCWTHAKN 940
            |..|.|::....:.|....:.:|. :..:|||.:||.|:|.....|.:        |....|.|:
Zfish   803 NPNISYQYYSDDVIVEIASKGKWS-TTISACSVTCGRGIQKIYQHCVD--------LVTLEHLKD 858

  Fly   941 K------RPARQSRGCGDQPCPAHWW---PGPWQFCPVTCRPVGFVAPPQRRRSVVCLDEHDVVV 996
            :      |.:...:.|....||..|.   ||.   |...|      .|.:.:|.|.|:..|:...
Zfish   859 ELCSSLPRSSDLLQPCFLPDCPPRWQVSEPGE---CSTVC------GPGEAQRKVFCVRFHNKSY 914

  Fly   997 ADAE---CGHLQKPAEMEPCESSLPICRTK 1023
            .:.:   |.. .||.|..||  .:.:|..|
Zfish   915 LEVDQNLCSQ-PKPPEYVPC--VVDVCPLK 941

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AdamTS-B	NP_572247.2	Pep_M12B_propep	78..194	CDD:279848
		ZnMc_ADAMTS_like	314..518	CDD:239801	66/206 (32%)
		Reprolysin	315..521	CDD:279729	67/208 (32%)
		ADAM_CR	<558..602	CDD:301627	17/50 (34%)
		TSP1	614..666	CDD:214559	21/51 (41%)
		ADAM_spacer1	773..886	CDD:283607	26/125 (21%)
		TSP1	901..956	CDD:214559	13/60 (22%)
adamts13	XP_002663267.4	Reprolysin	219..423	CDD:279729	67/209 (32%)
		ZnMc_ADAMTS_like	219..420	CDD:239801	66/206 (32%)
		TSP1	520..572	CDD:214559	21/51 (41%)
		TSP1	966..1023	CDD:214559
		TSP1	1154..1205	CDD:214559
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D125522at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR13723
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	3.020