DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment AdamTS-B and adamts18

DIOPT Version :9

Sequence 1:	NP_572247.2	Gene:	AdamTS-B / 31490	FlyBaseID:	FBgn0029791	Length:	1023	Species:	Drosophila melanogaster
Sequence 2:	XP_009301678.1	Gene:	adamts18 / 100150128	ZFINID:	ZDB-GENE-070815-1	Length:	1244	Species:	Danio rerio

Alignment Length:	1017	Identity:	345/1017 - (33%)
Similarity:	503/1017 - (49%)	Gaps:	123/1017 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    35 GLHSDELVAGEGQLVVPRRVHPDGAFMTHQLEYAHELDHRRH-RQRRSLNSEHDTQAADL-HLLL 97
            ||:.|.      ....|..|...|.:::|        |..|| |.||||     ::|..| |..:
Zfish    59 GLYQDY------DFATPVEVDSYGGYISH--------DVSRHGRSRRSL-----SEAGSLVHYHV 104

  Fly    98 PLANETLHLELMAHSYFLAPNLVVERHRRDLRTRSPLTTRHLNCHFHGKVRGQPATNVAISTCAG 162
            ....:.|||:|.. |:.||....|:....:....:.|.....||.:.|.:|....::||:|||.|
Zfish   105 SAFGKELHLDLQP-SHVLAEGFTVQTLGAEGINTATLDPSIHNCFYQGSIRNHSDSSVALSTCTG 168

  Fly   163 LVGHIRTAGNEYFIEPSKEH------EPHPVNGHPHVVFQRSSVKPKHSLRKRNKRKRGGKSGSG 221
            |.|.||.:..|.||.|..:|      ...|...||||:::||:.:..|:  .:..|....||.:.
Zfish   169 LSGLIRYSSEELFITPLPQHLALQHNYSAPSGHHPHVIYKRSAERRVHA--DKTDRTSRFKSSNP 231

  Fly   222 AEVSNCGTREPRRRMETRLEWQARGKVKVQGGRQIRRHHHHHHHHHHKHKYRHHQQKISRVPHTK 286
            .|                                   .||||||||..|.|:|.:.:.......:
Zfish   232 YE-----------------------------------DHHHHHHHHRHHDYQHGKLQRQHFCGRR 261

  Fly   287 FKYETQFQTE-----PDHAE--IPRRRRSISSPR----HVETLIVADATMSAFH-RD-LNGYLLT 338
            .:|..:..||     ||..|  |..:|..|:|.:    :||||:|||..|...| || :..|:||
Zfish   262 KQYTPKPPTEDHFVMPDEFEQQIRVKRSEITSSKEGGLNVETLVVADRKMLEKHGRDNVTTYVLT 326

  Fly   339 IMNMVSALYKDPSIGNSIEIVVVRIIQLDEEESQLQLNLTQNAQKNLDRFCSWQHKLNKGSEKDP 403
            :|||||:|:||.:|||.|.||||.::.|  |:..|.|::..:|.::|:.||.||..|   ..|:.
Zfish   327 VMNMVSSLFKDGTIGNDINIVVVSLLLL--EKDPLGLSINHHADQSLNSFCQWQSGL---VGKNG 386

  Fly   404 HHHDVAILITRKNICA---NNCMTLGLANVGGMCKPKQSCSVNEDNGIMLSHTITHELGHNFGMF 465
            ..||.|||:|..:||:   ..|.|||.|.:.|||...:||::|||.|:.|:.||.||.||||||.
Zfish   387 KRHDHAILLTGLDICSWKNEPCDTLGFAPISGMCSKYRSCTINEDTGLGLAFTIAHESGHNFGMI 451

  Fly   466 HDTAKIGCHPRVGPIVHIMTPTFGADTLQVCWSNCSRKYITHFLDQGLGECLDDPPTPLDEYNYT 530
            ||.....|....|   :||:||...:.....||.|||:|:..||......||.|.|..:.:|.|.
Zfish   452 HDGEGNPCRKTEG---NIMSPTLAGNNGVFSWSACSRQYLNRFLGTAQASCLVDEPKQIGQYKYP 513

  Fly   531 GELPGMRYNARGQCRLQFNLTTDSEVGACSAP--HEFCSTLWCKVNG-ECVTHMRPTAPGTLCGR 592
            .:|||..|:|..||:.||.    |:...|...  .:.|.:|||...| .|.|...|.|.||:||.
Zfish   514 EQLPGQLYDADIQCKWQFG----SKAKLCGLDFVKDICKSLWCHRTGHRCETKFMPAAEGTICGA 574

  Fly   593 NKWCQNGKCVRREELA--AVNGGWGDWSEWSECSRSCGGGVSTQQRECDNPVPANGGVFCIGERK 655
            :.||:.|:||:..:..  ||:|.|..|||||:|||:|||||..::|.|::|.|.:.|.||.|..:
Zfish   575 DMWCRKGQCVKFGDHGPKAVHGQWSGWSEWSDCSRTCGGGVMYRERSCNSPSPQHNGKFCQGPGR 639

  Fly   656 RYKICRKRPCPAEEPSFRAQQCARFDNVSYQGATYKWLPF--FDKNNPCKLFCSDVDDTIIANWG 718
            .:::|..:||..:...|||||||.:::..::|..|||.|:  .::.:.|||:|...|........
Zfish   640 LHQLCNTKPCQPDGVDFRAQQCAEYNSKPFRGWYYKWKPYTKVEEEDICKLYCIAEDFDFFFAMS 704

  Fly   719 ATVLDGTPCTLGTNNMCIDGICKKVGCDWIVDSEVQDDRCGVCGGSGDQCQPVRETYTDPFAAKD 783
            :.|.|||.|:.....:||||||:.||||.::.|:...|.||||.|....|:.....||....|.:
Zfish   705 SKVKDGTSCSDYKGGVCIDGICEPVGCDQVLGSKAALDACGVCKGDNSTCKFYSGQYTLQHRANE 769

  Fly   784 GAYVEIVTIPARARHILIRELANSPHFLAIATGDGGDRFYLNGDSLISMPGEFEIAGAESLYDR- 847
              |..:|.:||.||.|.::|:..|..:||:.:...| .:||..|..:..||.|:.||....|.|
Zfish   770 --YYPVVMVPAGARSIQVQEMEISNSYLAVRSLKRG-TYYLTADWTVDWPGRFQFAGTTFNYQRS 831

  Fly   848 VDEQETITIPQPIQHSISLYAIVRGNESNAGIFYEFTLPALNVTAGRQFQWRLSNWTACSASCGG 912
            .:..||:....|...::....:::|  .|.||.:|:|||  :......:.|.:.. :.|||.|.|
Zfish   832 FNRPETLFATGPTNETLLFEILLQG--KNPGITWEYTLP--HPEKKHNYTWSVVR-SDCSAPCAG 891

  Fly   913 GVQHREPICQENGKALGDTLPCWTHAKNKRPARQSRGCGDQPCPAHWWPGPWQFCPVTCRPVGFV 977
            |....:.||.::.:...::..|   ....||...|..|..|||||:|..|.|..|..||
Zfish   892 GRVSTKAICLQDQQTQVNSSLC---NPQTRPVVGSHLCNTQPCPAYWTTGKWGVCSRTC------ 947

  Fly   978 APPQRRRSVVCLD----EHDVVVADAECGHLQKPAEMEPCES 1015
            ...|:.|::.||.    :.:.|.|.:.| .:..||:::||.:
Zfish   948 GGGQQTRNIRCLRKVTYQREEVAAQSLC-PVMAPAQLQPCNT 988

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AdamTS-B	NP_572247.2	Pep_M12B_propep	78..194	CDD:279848	39/122 (32%)
		ZnMc_ADAMTS_like	314..518	CDD:239801	92/208 (44%)
		Reprolysin	315..521	CDD:279729	94/210 (45%)
		ADAM_CR	<558..602	CDD:301627	17/46 (37%)
		TSP1	614..666	CDD:214559	24/51 (47%)
		ADAM_spacer1	773..886	CDD:283607	34/113 (30%)
		TSP1	901..956	CDD:214559	15/54 (28%)
adamts18	XP_009301678.1	Pep_M12B_propep	86..206	CDD:279848	41/125 (33%)
		ZnMc_ADAMTS_like	299..500	CDD:239801	91/208 (44%)
		Reprolysin	301..504	CDD:279729	94/210 (45%)
		TSP1	598..649	CDD:214559	23/50 (46%)
		ADAM_spacer1	755..868	CDD:283607	34/117 (29%)
		TSP1	935..992	CDD:214559	17/61 (28%)
		TSP1	995..1053	CDD:214559
		TSP1	1060..1120	CDD:214559
		TSP1	1142..1189	CDD:214559
		PLAC	1210..1240	CDD:285849
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	210	1.000	Domainoid score	I2752
eggNOG	1	0.900	-	-		E1_KOG3538
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D125522at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm25151
orthoMCL	1	0.900	-	-		OOG6_100241
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	7	6.720