Protein Alignment AdamTS-B and LOC100001991

DIOPT Version :10

• Sequence 1: NP_572247.2
• Gene: AdamTS-B / 31490
• FlyBaseID: FBgn0029791
• Length: 1023
• Species: Drosophila melanogaster
• Sequence 2: XP_001341878.1
• Gene: LOC100001991 / 100001991
• -ID: -
• Length: 927
• Species: Danio rerio
• Alignment Length: 995
• Identity: 312/995 - (31%)
• Similarity: 461/995 - (46%)
• Gaps: 218/995 - (21%)

  Fly   106 LELMAHSYFLAPNLVVER--HRRDLRTRSPLTT--RHLN------------CHFHGKVRGQPATN 154
            |.|...|.|::|.|.|.|  .:...::.|.||.  :.||            |.:.|.|.....:.
Zfish    59 LNLTPDSTFISPALKVYRVKVKPQEKSTSNLTDLYQSLNQTEETGTEFLKGCFYTGFVDSSEDSV 123

  Fly   155 VAISTCAGLVGHIRTAGNEYFIEP--------SKEHEPHPVNGHPHVVFQRSSVKPKHSLRKRNK 211
            |::|.|.|::|...:.|.||.|||        .|..|      ..||:                |
Zfish   124 VSVSLCRGILGSFISDGKEYLIEPKSFGLGTKGKLTE------QLHVI----------------K 166

  Fly   212 RKRGGKSGSGAEVSNCGTREPRRRMETRLEWQARGKVKVQGGRQIRRHHHHHHHHHHKHKYRHHQ 276
            |:|..||   ::||       ::..:.|.:.|.
Zfish   167 RRRFAKS---SQVS-------KQLSDMRADLQN-------------------------------- 189

  Fly   277 QKISRVPHTKFKYETQFQTEPDHAEIP-RRRRSISSPRHVETLIVADATMSAFHRD-LNGYLLTI 339
               ||:                  ::| ||||.:|:||.:|||:|.||:::.|:.| :..|:||:
Zfish   190 ---SRI------------------QMPSRRRRFVSTPRFIETLVVGDASLTHFYGDEIKHYMLTL 233

  Fly   340 MNMVSALYKDPSIGNSIEIVVVRIIQLDEEESQLQLNLTQNAQKNLDRFCSWQHKLNKGSEKDPH 404
            |::.:.:||.|||.|||.||:|:::.:::||  :..:::.|....|..||:||...|..|.:.|.
Zfish   234 MSVAAQVYKHPSIKNSINIVLVKMLIVEDEE--VGPSISSNGGVALRSFCAWQQLFNPSSHRHPE 296

  Fly   405 HHDVAILITRKNICAN-NCMTLGLANVGGMCKPKQSCSVNEDNGIMLSHTITHELGHNFGMFHDT 468
            |:|.|||.||::||.: :|.|||:|:||.||..|:||||.||||:..::|..|||||...|.||.
Zfish   297 HYDTAILFTREDICGHQSCETLGVADVGTMCDTKRSCSVIEDNGLQAAYTTAHELGHVLSMPHDD 361

  Fly   469 AKIGCHPRVGPI--VHIMTPTFGADTLQVCWSNCSRKYITHFLDQGLGEC-LDDPPTPLDEYNYT 530
            .| .|....|.:  .|||.|.|...:....||.||..|:|.|.|.|.|:| ||.|.|.:   ...
Zfish   362 TK-SCEQLFGHLGEDHIMAPVFTQLSKTSPWSPCSALYVTEFFDNGHGDCLLDAPETTV---ALP 422

  Fly   531 GELPGMRYNARGQCRLQFNLTTDSEVGAC--SAPHEFCSTLWCKVNGE--CVTH--MRPTAPGTL 589
            .||||:.|:...||:..|.    .|...|  ::..|.|..|||:..|:  |.|.  ..|.|.||.
Zfish   423 TELPGLTYSLDRQCQQIFG----EEFSHCPNTSSSEVCERLWCQQEGQSMCTTRNGSLPWADGTS 483

  Fly   590 CGRNKWCQNGKCVRREEL----AAVNGGWGDWSEWSECSRSCGGGVSTQQRECDNPVPANGGVFC 650
            ||.|:.|.|..|:..|::    .||:||||:|..|..|||||||||....|||:.|.|.|||.:|
Zfish   484 CGTNRTCLNSVCMSSEDVLRPQPAVDGGWGEWGSWQPCSRSCGGGVMFSYRECNRPSPQNGGKYC 548

  Fly   651 IGERKRYKICRKRPCPAEE-PSFRAQQCARFDNVSY---QGATYKWLPFF---DKNNPCKLFCSD 708
            :|:|..|:.|.|:.|.... .|||.:||.:::|.::   .|...:|:|.:   ...:.|||||..
Zfish   549 VGQRVNYQSCNKQACENNRGKSFREEQCEKYNNPNHFDIHGNVKQWIPKYAGVSLRDRCKLFCRA 613

  Fly   709 VDDTIIANWGATVLDGTPCTLGTNNMCIDGICKKVGCDWIVDSEVQDDRCGVCGGSGDQCQPVRE 773
            ...:....:...|:|||||...|.:.|:.|.|.|.|||..:||..:.|:|.||||:|..|:.:
Zfish   614 RGSSEFRVFAPKVIDGTPCGPDTTSFCVQGQCIKAGCDLEIDSSKKLDKCAVCGGNGQSCRII-- 676

  Fly   774 TYTDPFAAKDGAYVEIVTIPARARHILIRE-----LANSPHFLAIATGDGGDRFYLNGDSLIS-- 831
              :..|......|.:|||||:.|.:|.|::     :.:..|:||:...:|  .:.|||:..:|
Zfish   677 --SGSFNKVVHGYRDIVTIPSGATNINIKQQSHGSIPHDGHYLAVRRENG--NYILNGNFSVSTV 737

  Fly   832 ------MPGEFEIAGAESLYDRVDE----QETIT----------IPQPIQHSISLYAIVRGNESN 876
                  :....:.:|:.:..:|:..    ||.||          ||..::::
Zfish   738 EQHIPVLGAVLKYSGSSTTLERLQSFRQLQEPITIQLLSTAAESIPPKVKYT------------- 789

  Fly   877 AGIFY-----EFTLPALNVTAGRQF------QWRLSNWTACSASCGGGVQHREPICQENGKALGD 930
               ||     .|:.|.....||:..      ||..|.|:.||.:||.|...|...|::|.....:
Zfish   790 ---FYIPKSMAFSKPKDKKIAGKLIHPFGVPQWISSEWSECSKTCGSGWSRRNVECKDNAGFYSN 851

  Fly   931 TLPCWTHA-KNKRPARQSRGCGDQPCPAHWWPGPWQFCPVTCRPVGFVAPPQRRRSVVCLDEHDV 994
                  |. |:.||: ..|.|.|.|||. |..|||..|..||      ...:|:|.::|:|....
Zfish   852 ------HCNKDLRPS-DIRPCADLPCPI-WQIGPWSSCSQTC------GHGERQRKILCIDYTGK 902

  Fly   995 VVADAECGHLQKPAEM-EPC 1013
            .|....|...:.|..: |.|
Zfish   903 TVEPENCDPAKMPESVSEKC 922

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
AdamTS-B	NP_572247.2	Pep_M12B_propep	47..195	CDD:460254	31/112 (28%)
		ZnMc_ADAMTS_like	314..518	CDD:239801	89/208 (43%)
		ADAMTS_CR_2	534..602	CDD:465496	25/73 (34%)
		TSP1	614..666	CDD:214559	27/51 (53%)
		ADAMTS_CR_3	672..768	CDD:437068	36/101 (36%)
		ADAMTS_spacer1	770..886	CDD:461796	29/147 (20%)
		TSP1	901..956	CDD:214559	18/55 (33%)
		TSP1_ADAMTS	959..1020	CDD:465950	16/56 (29%)
LOC100001991	XP_001341878.1	Pep_M12B_propep	24..147	CDD:460254	25/87 (29%)
		ZnMc_ADAMTS_like	206..412	CDD:239801	90/208 (43%)
		ADAMTS_CR_2	426..495	CDD:465496	25/72 (35%)
		TSP1	512..564	CDD:214559	27/51 (53%)
		ADAMTS_CR_3	<595..673	CDD:437068	29/77 (38%)
		ADAMTS_spacer1	675..793	CDD:461796	28/139 (20%)
		TSP1_ADAMTS	819..870	CDD:465950	18/57 (32%)
		TSP1_ADAMTS	873..927	CDD:465950	16/56 (29%)