DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment AdamTS-B and LOC100001991

DIOPT Version :9

Sequence 1:	NP_572247.2	Gene:	AdamTS-B / 31490	FlyBaseID:	FBgn0029791	Length:	1023	Species:	Drosophila melanogaster
Sequence 2:	XP_001341878.1	Gene:	LOC100001991 / 100001991	-ID:	-	Length:	927	Species:	Danio rerio

Alignment Length:	995	Identity:	312/995 - (31%)
Similarity:	461/995 - (46%)	Gaps:	218/995 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   106 LELMAHSYFLAPNLVVER--HRRDLRTRSPLTT--RHLN------------CHFHGKVRGQPATN 154
            |.|...|.|::|.|.|.|  .:...::.|.||.  :.||            |.:.|.|.....:.
Zfish    59 LNLTPDSTFISPALKVYRVKVKPQEKSTSNLTDLYQSLNQTEETGTEFLKGCFYTGFVDSSEDSV 123

  Fly   155 VAISTCAGLVGHIRTAGNEYFIEP--------SKEHEPHPVNGHPHVVFQRSSVKPKHSLRKRNK 211
            |::|.|.|::|...:.|.||.|||        .|..|      ..||:                |
Zfish   124 VSVSLCRGILGSFISDGKEYLIEPKSFGLGTKGKLTE------QLHVI----------------K 166

  Fly   212 RKRGGKSGSGAEVSNCGTREPRRRMETRLEWQARGKVKVQGGRQIRRHHHHHHHHHHKHKYRHHQ 276
            |:|..||   ::||       ::..:.|.:.|.
Zfish   167 RRRFAKS---SQVS-------KQLSDMRADLQN-------------------------------- 189

  Fly   277 QKISRVPHTKFKYETQFQTEPDHAEIP-RRRRSISSPRHVETLIVADATMSAFHRD-LNGYLLTI 339
               ||:                  ::| ||||.:|:||.:|||:|.||:::.|:.| :..|:||:
Zfish   190 ---SRI------------------QMPSRRRRFVSTPRFIETLVVGDASLTHFYGDEIKHYMLTL 233

  Fly   340 MNMVSALYKDPSIGNSIEIVVVRIIQLDEEESQLQLNLTQNAQKNLDRFCSWQHKLNKGSEKDPH 404
            |::.:.:||.|||.|||.||:|:::.:::||  :..:::.|....|..||:||...|..|.:.|.
Zfish   234 MSVAAQVYKHPSIKNSINIVLVKMLIVEDEE--VGPSISSNGGVALRSFCAWQQLFNPSSHRHPE 296

  Fly   405 HHDVAILITRKNICAN-NCMTLGLANVGGMCKPKQSCSVNEDNGIMLSHTITHELGHNFGMFHDT 468
            |:|.|||.||::||.: :|.|||:|:||.||..|:||||.||||:..::|..|||||...|.||.
Zfish   297 HYDTAILFTREDICGHQSCETLGVADVGTMCDTKRSCSVIEDNGLQAAYTTAHELGHVLSMPHDD 361

  Fly   469 AKIGCHPRVGPI--VHIMTPTFGADTLQVCWSNCSRKYITHFLDQGLGEC-LDDPPTPLDEYNYT 530
            .| .|....|.:  .|||.|.|...:....||.||..|:|.|.|.|.|:| ||.|.|.:   ...
Zfish   362 TK-SCEQLFGHLGEDHIMAPVFTQLSKTSPWSPCSALYVTEFFDNGHGDCLLDAPETTV---ALP 422

  Fly   531 GELPGMRYNARGQCRLQFNLTTDSEVGAC--SAPHEFCSTLWCKVNGE--CVTH--MRPTAPGTL 589
            .||||:.|:...||:..|.    .|...|  ::..|.|..|||:..|:  |.|.  ..|.|.||.
Zfish   423 TELPGLTYSLDRQCQQIFG----EEFSHCPNTSSSEVCERLWCQQEGQSMCTTRNGSLPWADGTS 483

  Fly   590 CGRNKWCQNGKCVRREEL----AAVNGGWGDWSEWSECSRSCGGGVSTQQRECDNPVPANGGVFC 650
            ||.|:.|.|..|:..|::    .||:||||:|..|..|||||||||....|||:.|.|.|||.:|
Zfish   484 CGTNRTCLNSVCMSSEDVLRPQPAVDGGWGEWGSWQPCSRSCGGGVMFSYRECNRPSPQNGGKYC 548

  Fly   651 IGERKRYKICRKRPCPAEE-PSFRAQQCARFDNVSY---QGATYKWLPFF---DKNNPCKLFCSD 708
            :|:|..|:.|.|:.|.... .|||.:||.:::|.::   .|...:|:|.:   ...:.|||||..
Zfish   549 VGQRVNYQSCNKQACENNRGKSFREEQCEKYNNPNHFDIHGNVKQWIPKYAGVSLRDRCKLFCRA 613

  Fly   709 VDDTIIANWGATVLDGTPCTLGTNNMCIDGICKKVGCDWIVDSEVQDDRCGVCGGSGDQCQPVRE 773
            ...:....:...|:|||||...|.:.|:.|.|.|.|||..:||..:.|:|.||||:|..|:.:
Zfish   614 RGSSEFRVFAPKVIDGTPCGPDTTSFCVQGQCIKAGCDLEIDSSKKLDKCAVCGGNGQSCRII-- 676

  Fly   774 TYTDPFAAKDGAYVEIVTIPARARHILIRE-----LANSPHFLAIATGDGGDRFYLNGDSLIS-- 831
              :..|......|.:|||||:.|.:|.|::     :.:..|:||:...:|  .:.|||:..:|
Zfish   677 --SGSFNKVVHGYRDIVTIPSGATNINIKQQSHGSIPHDGHYLAVRRENG--NYILNGNFSVSTV 737

  Fly   832 ------MPGEFEIAGAESLYDRVDE----QETIT----------IPQPIQHSISLYAIVRGNESN 876
                  :....:.:|:.:..:|:..    ||.||          ||..::::
Zfish   738 EQHIPVLGAVLKYSGSSTTLERLQSFRQLQEPITIQLLSTAAESIPPKVKYT------------- 789

  Fly   877 AGIFY-----EFTLPALNVTAGRQF------QWRLSNWTACSASCGGGVQHREPICQENGKALGD 930
               ||     .|:.|.....||:..      ||..|.|:.||.:||.|...|...|::|.....:
Zfish   790 ---FYIPKSMAFSKPKDKKIAGKLIHPFGVPQWISSEWSECSKTCGSGWSRRNVECKDNAGFYSN 851

  Fly   931 TLPCWTHA-KNKRPARQSRGCGDQPCPAHWWPGPWQFCPVTCRPVGFVAPPQRRRSVVCLDEHDV 994
                  |. |:.||: ..|.|.|.|||. |..|||..|..||      ...:|:|.::|:|....
Zfish   852 ------HCNKDLRPS-DIRPCADLPCPI-WQIGPWSSCSQTC------GHGERQRKILCIDYTGK 902

  Fly   995 VVADAECGHLQKPAEM-EPC 1013
            .|....|...:.|..: |.|
Zfish   903 TVEPENCDPAKMPESVSEKC 922

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AdamTS-B	NP_572247.2	Pep_M12B_propep	78..194	CDD:279848	30/111 (27%)
		ZnMc_ADAMTS_like	314..518	CDD:239801	89/208 (43%)
		Reprolysin	315..521	CDD:279729	91/210 (43%)
		ADAM_CR	<558..602	CDD:301627	18/49 (37%)
		TSP1	614..666	CDD:214559	27/51 (53%)
		ADAM_spacer1	773..886	CDD:283607	29/144 (20%)
		TSP1	901..956	CDD:214559	18/55 (33%)
LOC100001991	XP_001341878.1	Pep_M12B_propep	40..165	CDD:279848	30/111 (27%)
		Reprolysin	206..415	CDD:279729	92/211 (44%)
		ZnMc_ADAMTS_like	206..412	CDD:239801	90/208 (43%)
		ADAM_CR	425..495	CDD:301627	26/73 (36%)
		TSP1	512..564	CDD:214559	27/51 (53%)
		ADAM_spacer1	674..793	CDD:283607	28/140 (20%)
		TSP1	822..871	CDD:214559	18/55 (33%)
		TSP1	873..915	CDD:214559	13/47 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3538
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D125522at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100241
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.720